10 research outputs found
Synthesis of novel beta-aryl-beta-(methylthio)acroleins via Vilsmeier-Haack protocol as potential 1,3-dielectrophilic three-carbon building blocks
No full textA new general route for the synthesis of novel beta-aryl-beta-(methylthio)acroleins, a class of stable potential 1,3-dielectrophilic synthons, has been reported. The overall protocol involves treatment of either beta-chloroacroleins or their precursor iminium salts (generated in situ from the corresponding active methylene ketones under Vilsmeier-Haack reaction conditions) with S,S-dimethyldithiocarbonates (DDC)/aqueous KOH in either a one-pot or two-step process. The dimethyldithiocarbonate (DDC)/30% aqueous KOH has been shown to be an excellent source of methylthiolate anion. (C) 2014 Elsevier Ltd. All rights reserved
Synthesis of Highly Functionalized Isoxazolinediones from One-pot Reaction of Alkylidene Meldrum’s Acid with Alkyl Isocyanides in the Presence of Arylhydroxylamines
No full textSynthesis of new isoxazoles and dihydroisoxazoles and in vitro evaluation of their antifungal activity
No full textSynthesis, characterization, and antibacterial activity of a novel heterocyclic Schiff’s base and its metal complexes of first transition series
No full textGenistein, a potent inhibitor of secretory phospholipase A2: a new insight in down regulation of inflammation
No full text3,5-Disubstituted Isoxazole Derivatives: Potential Inhibitors of Inflammation and Cancer
No full textSuramin inhibits cell proliferation in ovarian and cervical cancer by downregulating heparanase expression
No full text
