Monitorage hémodynamique de la dysfonction myocardique chez l'enfant au moyen d'un dispositif d'echo-doppler oesophagien

GRENOBLE1-BU Médecine pharm. (385162101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Les céramiques injectées sous pression (une situation clinique après 20 ans)

LYON1-BU Santé Odontologie (693882213) / SudocSudocFranceF

Les relations entre confort du logement et boiteries en troupeau bovin laitier

Le confort du logement a depuis longtemps été reconnu comme un élément clé dans la gestion des boiteries chez les bovins. Une durée trop longue passée avec les pieds sur du béton prédispose aux affections de la corne, tandis que des défauts d’hygiène sont un facteur clé dans l’apparition et le maintien de la dermatite digitée et du fourchet. Un défaut de confort handicape également les vaches atteintes de boiterie, et peut même aggraver la boiterie. Pour détecter un problème de confort du logement, différents indicateurs doivent être récoltés pour observer les animaux, puis leur logement, et interroger l’éleveur en fonction des lésions majoritairement impliquées dans les boiteries. Des changements simples à mettre en œuvre peuvent souvent permettre d’améliorer la situation. De nombreux travaux sont en cours sur la conception de bâtiments pour améliorer, entre autres, la santé des pieds et in fine le bien-être des bovins et la satisfaction des éleveurs

Le bien-être des animaux d'élevage: Améliorer le bien-être animal

National audienceAprès les fascicules « Comprendre » et « Évaluer », cet ouvrage présente des pistes pour améliorer le bien-être des animaux d’élevage, focalisées sur l’environnement physique et social des animaux, la relation humain-animal, la prise en charge de la douleur, ainsi que la bientraitance dans le transport et l’abattage. Certains leviers d’amélioration sont particulièrement distingués, tels que la création de relations positives, fondées sur une meilleure compréhension des animaux, la gestion intégrée de leur santé et la valorisation de solutions pour supprimer, substituer ou soulager des pratiques douloureuses.La mise en place d’actions doit bien sûr être adaptée à chaque élevage, et respecter aussi le bien-être de l’éleveur. Cette démarche s’inscrit dans le concept de one welfare, où les bénéfices pour l’animal, pour l’humain et pour l’environnement sont étroitement liés.Cet ouvrage s’adresse aux étudiants et aux professionnels des filières agricole et vétérinaire, ainsi qu’à tout citoyen s’intéressant au bien-être des animaux d’élevage.Le Laurier 2021 Impact de la recherche a récompensé le collectif INRAE « Bien-être animal », chercheurs et chercheuses en éthologie, physiologie, neurobiologie et génétique, dont sont issus une partie des auteurs et des contributeurs de cet ouvrage

Relationships between welfare and reproductive performance in French dairy herds

This study aimed to investigate the relationship between cow reproductive performance and welfare evaluated at the herd level using the Welfare Quality protocol. The 11 criteria, four principles (good feeding, good housing, good health and appropriate behavior, scale 0-100) and overall welfare category (excellent/enhanced/acceptable/not classified = poor welfare) were included as risk factors for calving to first service interval (CFSI) and calving rate (CR). The confounding factors cow breed, parity, season of calving and AI, calving to AI interval, rank of AI (1-3) and milk production were taken into account. The sample included 3951 AIs (2172 AI1, 1182 AI2, 597 AI3) in 124 French commercial dairy herds. Median CFSI was shorter for the cows bred in herds with a higher overall welfare category (median 75 and 76 days in enhanced and acceptable herds vs. 86 in poor welfare ones, P =  0.02). The scores for absence of injuries and expression of social behavior tended to be associated with CFSI (P <  0.10). Calving rate (34.5%) was not related to the overall welfare category. However, CR was positively related to the good housing score and a positive trend was observed with the scores for absence of prolonged hunger and absence of injuries. In conclusion, this study confirms a positive relationship between CFSI and welfare in dairy cows with no explicit links with specific aspects of animal welfa

Identification of putative interactors of arabidopsis sugar transporters

National audienc

Serotonin reuptake inhibitors improve muscle stem cell function and muscle regeneration in male mice

Abstract Serotonin reuptake inhibitor antidepressants such as fluoxetine are widely used to treat mood disorders. The mechanisms of action include an increase in extracellular level of serotonin, neurogenesis, and growth of vessels in the brain. We investigated whether fluoxetine could have broader peripheral regenerative properties. Following prolonged administration of fluoxetine in male mice, we showed that fluoxetine increases the number of muscle stem cells and muscle angiogenesis, associated with positive changes in skeletal muscle function. Fluoxetine also improved skeletal muscle regeneration after single and multiples injuries with an increased muscle stem cells pool and vessel density associated with reduced fibrotic lesions and inflammation. Mice devoid of peripheral serotonin treated with fluoxetine did not exhibit beneficial effects during muscle regeneration. Specifically, pharmacological, and genetic inactivation of the 5-HT1B subtype serotonin receptor also abolished the enhanced regenerative process induced by fluoxetine. We highlight here a regenerative property of serotonin on skeletal muscle

Post-Thrombolysis Recanalization in Stroke Referrals for Thrombectomy

International audienceBackground and Purpose—Whether all acute stroke patients with large vessel occlusion need to undergo intravenous thrombolysis before mechanical thrombectomy (MT) is debated as (1) the incidence of post-thrombolysis early recanalization (ER) is still unclear; (2) thrombolysis may be harmful in patients unlikely to recanalize; and, conversely, (3) transfer for MT may be unnecessary in patients highly likely to recanalize. Here, we determined the incidence and predictors of post-thrombolysis ER in patients referred for MT and derive ER prediction scores for trial design. Methods—Registries from 4 MT-capable centers gathering patients referred for MT and thrombolyzed either on site (mothership) or in a non MT-capable center (drip-and-ship) after magnetic resonance– or computed tomography–based imaging between 2015 and 2017. ER was identified on either first angiographic run or noninvasive imaging. In the magnetic resonance imaging subsample, thrombus length was determined on T2*-based susceptibility vessel sign. Independent predictors of no- ER were identified using multivariable logistic regression models, and scores were developed according to the magnitude of regression coefficients. Similar registries from 4 additional MT-capable centers were used as validation cohort. Results—In the derivation cohort (N=633), ER incidence was ≈20%. In patients with susceptibility vessel sign (n=498), no-ER was independently predicted by long thrombus, proximal occlusion, and mothership paradigm. A 6-point score derived from these variables showed strong discriminative power for no-ER (C statistic, 0.854) and was replicated in the validation cohort (n=353; C statistic, 0.888). A second score derived from the whole sample (including negative T2* or computed tomography–based imaging) also showed good discriminative power and was similarly validated. Highest grades on both scores predicted no-ER with >90% specificity, whereas low grades did not reliably predict ER. Conclusions—The substantial ER rate underlines the benefits derived from thrombolysis in bridging populations. Both prediction scores afforded high specificity for no-ER, but not for ER, which has implications for trial design