33 research outputs found
Islet Cell Antibodies Represent Autoimmune Response Against Several Antigens
To study the antigens involved in the islet cell
antibody (ICA) reaction we selected 30 patient
serum samples (ten in each group) positive for ICA
and one other additional autoantibody, such as
glutamic acid decarboxylase antibodies (GADA),
thyrosine phosphatase antibodies (IA-2A) or insulin
autoantibodies (IAA). The serum samples were
incubated with the specific antigen (GAD65, IA-2 or
insulin) and the ICA analysis and the corresponding
immunoprecipitation assay were performed before
and after the absorption