On the cause of Saturn's plasma periodicity

Periodic plasma enhancements are examined for all Cassini orbits from December 29, 2005 through September 7, 2006. The events, which have UT durations of 3-4 hours, are centered near SLS3 longitude 10 degrees at radial distances near 15 R-S and at larger W longitudes at larger distances, reaching 180 degrees W by 49 R-S. Magnetic-field data within the events and outside 30 to 35 R-S show signatures of neutral-sheet crossings and magnetic reconnection (i.e., plasmoids). We conclude that plasmoids move outward from 30-35 R-S along a spiral path that rotates with the planet. The duration of these events is similar to that of SKR events, and they are ordered in the SKR-based SLS3 longitude system. A conceptual model, in which the plasmoids are triggered in the pre-midnight quadrant following (with a predictable delay) the appearance of SKR at the magnetopause and then propagate outward in a rotating spiral pattern, can explain the connection among periodicities observed in Saturn's charged particles, magnetic fields, and kilometric radiation

Daptomycin as a possible new treatment option for surgical management of Methicillin-Resistant Staphylococcus aureus sternal wound infection after cardiac surgery

We present a case of a 77-year old female who had undergone a coronary artery bypass grafting with an aortic valve replacement and developed three month later a Methicillin-Resistant Staphylococcus aureus (MRSA) sternal wound infection which was successful treated with Daptomycin combined with vacuum-assisted closure (VAC)

A study of reliability-centred maintenance in maritime operations

This paper has identified specific problems likely to be encountered in endeavour of implementing reliability-centred maintenance (RCM) on ships. These stem out of the cultural differences between the aviation and maritime industries. In the maritime industry, RCM is often considered resource demanding. It is however possible to make the project manageable by starting with a critical system. Considerable savings in time and effort can also be achieved by using a reverse logic where the failure modes are identified by analysing the maintenance tasks. A subjective qualitative approach has been proposed to overcome the limitations of the definitive logic used by the decision trees and the demand for failure data imposed by quantitative methods. A fuel oil purification system has been used as a test case to demonstrate its use. There is appreciation amongst both classification societies and equipment suppliers of the principles of RCM in the maritime industry. This makes the application of the RCM concept feasible. Finally it is the seafarer, who will have to be on the forefront of this endeavour and total productive maintenance can be used to create the right work environment to achieve this. It is concluded that rather than looking at RCM as a methodology and trying to use it as such, it makes more sense to consider it as a philosophy and use its guiding principles to help the seafarer plan his maintenance strategy. (C) 2002 .

613 cases of splenic rupture without risk factors or previously diagnosed disease: a systematic review

Background Rupture of the spleen in the absence of trauma or previously diagnosed disease is largely ignored in the emergency literature and is often not documented as such in journals from other fields. We have conducted a systematic review of the literature to highlight the surprisingly frequent occurrence of this phenomenon and to document the diversity of diseases that can present in this fashion. Methods Systematic review of English and French language publications catalogued in Pubmed, Embase and CINAHL between 1950 and 2011. Results We found 613 cases of splenic rupture meeting the criteria above, 327 of which occurred as the presenting complaint of an underlying disease and 112 of which occurred following a medical procedure. Rupture appeared to occur spontaneously in histologically normal (but not necessarily normal size) spleens in 35 cases and after minor trauma in 23 cases. Medications were implicated in 47 cases, a splenic or adjacent anatomical abnormality in 31 cases and pregnancy or its complications in 38 cases. The most common associated diseases were infectious (n = 143), haematologic (n = 84) and non-haematologic neoplasms (n = 48). Amyloidosis (n = 24), internal trauma such as cough or vomiting (n = 17) and rheumatologic diseases (n = 10) are less frequently reported. Colonoscopy (n = 87) was the procedure reported most frequently as a cause of rupture. The anatomic abnormalities associated with rupture include splenic cysts (n = 6), infarction (n = 6) and hamartomata (n = 5). Medications associated with rupture include anticoagulants (n = 21), thrombolytics (n = 13) and recombinant G-CSF (n = 10). Other causes or associations reported very infrequently include other endoscopy, pulmonary, cardiac or abdominal surgery, hysterectomy, peliosis, empyema, remote pancreato-renal transplant, thrombosed splenic vein, hemangiomata, pancreatic pseudocysts, splenic artery aneurysm, cholesterol embolism, splenic granuloma, congenital diaphragmatic hernia, rib exostosis, pancreatitis, Gaucher's disease, Wilson's disease, pheochromocytoma, afibrinogenemia and ruptured ectopic pregnancy. Conclusions Emergency physicians should be attuned to the fact that rupture of the spleen can occur in the absence of major trauma or previously diagnosed splenic disease. The occurrence of such a rupture is likely to be the manifesting complaint of an underlying disease. Furthermore, colonoscopy should be more widely documented as a cause of splenic rupture

Modulation of Phosphorylation of Tocopherol and Phosphatidylinositol by hTAP1/SEC14L2-Mediated Lipid Exchange

The vitamin E derivative, alpha-tocopheryl phosphate (αTP), is detectable in cultured cells, plasma and tissues in small amounts, suggesting the existence of enzyme(s) with α-tocopherol (αT) kinase activity. Here, we characterize the production of αTP from αT and [γ-32P]-ATP in primary human coronary artery smooth muscle cells (HCA-SMC) using separation by thin layer chromatography (TLC) and subsequent analysis by Ultra Performance Liquid Chromatography (UPLC). In addition to αT, although to a lower amount, also γT is phosphorylated. In THP-1 monocytes, γTP inhibits cell proliferation and reduces CD36 scavenger receptor expression more potently than αTP. Both αTP and γTP activate the promoter of the human vascular endothelial growth factor (VEGF) gene with similar potency, whereas αT and γT had no significant effect. The recombinant human tocopherol associated protein 1 (hTAP1, hSEC14L2) binds both αT and αTP and stimulates phosphorylation of αT possibly by facilitating its transport and presentation to a putative αT kinase. Recombinant hTAP1 reduces the in vitro activity of the phosphatidylinositol-3-kinase gamma (PI3Kγ) indicating the formation of a stalled/inactive hTAP1/PI3Kγ heterodimer. The addition of αT, βT, γT, δT or αTP differentially stimulates PI3Kγ, suggesting facilitated egress of sequestered PI from hTAP1 to the enzyme. It is suggested that the continuous competitive exchange of different lipophilic ligands in hTAPs with cell enzymes and membranes may be a way to make these lipophiles more accessible as substrates for enzymes and as components of specific membrane domains