Child μ-Opioid Receptor Gene Variant Influences Parent–Child Relations

Variation in the μ-opioid receptor gene has been associated with early social behavior in mice and rhesus macaques. The current study tested whether the functional OPRM1 A118G predicted various indices of social relations in children. The sample included 226 subjects of self-reported European ancestry (44% female; mean age 13.6, SD=2.2) who were part of a larger representative study of children aged 9–17 years in rural North Carolina. Multiple aspects of recent (past 3 months) parent–child relationship were assessed using the Child and Adolescent Psychiatric Assessment. Parent problems were coded based upon a lifetime history of mental health problems, substance abuse, or criminality. Child genotype interacted with parent behavior such that there were no genotype differences for those with low levels of parent problems; however, when a history of parent problems was reported, the G allele carriers had more enjoyment of parent–child interactions (mean ratio (MR)=3.5, 95% CI=1.6, 8.0) and fewer arguments (MR=3.1, 95% CI=1.1, 8.9). These findings suggest a role for the OPRM1 gene in the genetic architecture of social relations in humans. In summary, a variant in the μ-opioid receptor gene (118G) was associated with improved parent–child relations, but only in the context of a significant disruption in parental functioning

Relations between suicidal ideation, depression, and emotional autonomy from parents in adolescence

We examined the relations between depression, emotional autonomy quality-related constructs of separation and detachment, and suicidal ideation, focusing on the unique and common contribution that depression, separation and detachment made to suicidal ideation. We also examined gender differences. 403 adolescents, 196 boys and 207 girls, completed self-report measures of depression, separation and detachment, and suicidal ideation. The data showed a significant relation between depression and suicidal ideation both for boys and girls, and between detachment and suicidal ideation only for boys. Results for boys supported an additive model such that depression and detachment each contributed unique variance to boys’ suicidal ideation, and an interactive model such that detachment contributed to exacerbate the risk of suicidal ideation when boys were already at risk because of depression. The data for girls supported an interactive, but not additive, model such that depression and detachment did not contribute independently to girls’ suicidal ideation but in a joint way