14 research outputs found
An experimental study of cathodic protection for chloride contaminated reinforced concrete
Cathodic protection (CP) is being increasingly used on reinforced concrete structures to protect steel reinforcing bars from corrosion in aggressive conditions. Due to the complexity of environmental conditions, the design specifications in national and international standards are still open to discussion to achieve both sufficient and efficient protection for reinforced concrete structures in engineering practices. This paper reports an experimental research to investigate the influence of chloride content on concrete resistivity, rebar corrosion rate and the performance of CP operation using different current densities. It aims to understand the correlation between the chloride content and concrete resistivity together with the CP current requirement, and to investigate the precision of the CP design criteria in standards
The use of neogastropods as indicator of tributyltin contamination along the South China coast
3rd Editio
Is individual metallothionein isoform a better biomarker for monitoring metal contamination than total metallothioneins
Poster Presentation - Ecotoxicology In Special Areas: no. 29The 15th International Symposium on Pollutant Responses in Marine Organisms (PRIMO), Bordeaux, France, 17-20 May 2009
Differential expression of two distinctive metallothionein isoforms in the rock shell Thais clavigera in relation to different chemical stressors
Expression of nicotinic acetylcholine receptor in human bronchial epithelium is associated with severity of airflow obstruction
Session B71. Crazy Muscles: Airway and Lymphatic Smooth Muscle and Lymphangioleiomyomatosis (LAM): abstract no. A3656link_to_OA_fulltex
Genome-wide gene expression profiling of cervical cancer in Hong Kong women by oligonucleotide microarray
An analysis of gene expression profiles obtained from cervical cancers was performed to find those genes most aberrantly expressed. Total RNA was prepared from 29 samples of cervical squamous cell carcinoma and 18 control samples, and hybridized to Affymetrix oligonucleotide microarrays with probe sets complementary to over 20,000 transcripts. Unsupervised hierarchical clustering of the expression data readily distinguished normal cervix from cancer. Supervised analysis of gene expression data identified 98 and 139 genes that exhibited >2-fold upregulation and >2-fold down-regulation, respectively, in cervical cancer compared to normal cervix. Several of the genes that were differentially regulated included SPP1 (Osteopontin), CDKN2A (p16), RPL39L, Clorf1, MAL, p11, ARS and NICE-1, These were validated by quantitative RT-PCR on an independent set of cancer and control specimens. Gene Ontology analysis showed that the list of differentially expressed genes included ones that were involved in multiple biological processes, including cell proliferation, cell cycle and protein catabolism. Immunohistochemical staining of cancer specimens further confirmed differential expression of SPP1 in cervical cancer cells vs. nontumor cells. In addition, 2 genes, CTGF and RGS1 were found to be upregulated in late stage cancer compared to early stage cancer, suggesting that they might be involved in cancer progression. The pathway analysis of expression data showed that the SPP1, VEGF, CDC2 and CKS2 genes were coordinately differentially regulated between cancer and normal. The present study is promising and provides potential new insights into the extent of expression differences underlying the development and progression of cervical squamous cell cancer. This study has also revealed several genes that may be highly attractive candidate molecular markers/targets for cervical cancer diagnosis, prognosis and therapy. © 2005 Wiley-Liss, Inc.link_to_subscribed_fulltex