25 research outputs found

    Transduction of Human T Cells with a Novel T-Cell Receptor Confers Anti-HCV Reactivity

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    Hepatitis C Virus (HCV) is a major public health concern, with no effective vaccines currently available and 3% of the world's population being infected. Despite the existence of both B- and T-cell immunity in HCV-infected patients, chronic viral infection and HCV-related malignancies progress. Here we report the identification of a novel HCV TCR from an HLA-A2-restricted, HCV NS3:1073–1081-reactive CTL clone isolated from a patient with chronic HCV infection. We characterized this HCV TCR by expressing it in human T cells and analyzed the function of the resulting HCV TCR-transduced cells. Our results indicate that both the HCV TCR-transduced CD4+ and CD8+ T cells recognized the HCV NS3:1073–1081 peptide-loaded targets and HCV+ hepatocellular carcinoma cells (HCC) in a polyfunctional manner with cytokine (IFN-γ, IL-2, and TNF-α) production as well as cytotoxicity. Tumor cell recognition by HCV TCR transduced CD8− Jurkat cells and CD4+ PBL-derived T cells indicated this TCR was CD8-independent, a property consistent with other high affinity TCRs. HCV TCR-transduced T cells may be promising for the treatment of patients with chronic HCV infections

    Measurement of CP asymmetry in D-0 -> K- K+ and D-0 -> pi(-) pi(+) decays

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    Time-integrated CP asymmetries in D-0 decays to the final states K- K+ and pi(-) pi(+) are measured using proton-proton collisions corresponding to 3 fb(-1) of integrated luminosity collected at centre-of-mass energies of 7 TeV and 8 TeV. The D-0 mesons are produced in semileptonic b-hadron decays, where the charge of the accompanying muon is used to determine the initial flavour of the charm meson. The difference in CP asymmetries between the two final states is measured to be Delta A(CP) = A(CP)(K- K+) ¿ A(CP)(pi(-) pi(+)) = (+0.14 +/- 0.16 (stat) +/- 0.08 (syst))% . A measurement of A(CP)(K- K+) is obtained assuming negligible CP violation in charm mixing and in Cabibbo-favoured D decays. It is found to be A(CP)(K- K+) = (-0.06 +/- 0.15 (stat) +/- 0.10 (syst))% , where the correlation coefficient between Delta A(CP) and A(CP)(K- K+) is rho = 0.28. By combining these results, the CP asymmetry in the D-0 -> pi(-) pi(+) channel is A(CP)(pi(-) pi(+)) = (-0.20 +/- 0.19 (stat) +/- 0.10 (syst))%

    Which educational interventions improve healthcare professionals’ resilience?

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    INTRODUCTION : This literature review summarizes the current evidence on educational interventions to develop healthcare worker resilience. METHODS : Electronic databases were systematically searched using the search terms: education OR training OR medical students AND resilience. The initial search was refined using criteria including population (healthcare students and professionals), interventions (educational), and outcome (resilience changes). RESULTS : Resilience has been defined and measured in various ways. The following educational interventions to develop resilience were identified: resilience workshops, small group problem solving, reflection, cognitive behavioral training, mindfulness and relaxation training, and mentoring. CONCLUSIONS : The strongest evidence was for using resilience workshops, cognitive behavioral training, or a combination of interventions. The literature is sometimes conflicting suggesting that developing resilience is a complex process, and our understanding is not fully developed.http://www.tandfonline.com/loi/imte202017-08-30Family Medicin

    Mindfulness-Based Interventions for Addiction

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