10 research outputs found
High field MRI correlates of myelin content and axonal density in multiple sclerosis - A post-mortem study of the spinal cord
Different MRI techniques are used to investigate multiple sclerosis (MS) in vivo. The pathological specificity of these techniques is poorly understood, in particular their relationship to demyelination and axonal loss.The aim of this study was to evaluate the pathological substrate of high field MRI in post-mortem (PM) spinal cord (SC) of patients with MS. MRI was performed in PMSCs of four MS patients and a healthy subject on a 7 Tesla machine.Quantitative MRI maps (PD; T2; T1; magnetization transfer ratio, MTR; diffusion weighted imaging) were obtained. After scanning, the myelin content and the axonal density of the specimens were evaluated neuropathologically using quantitative techniques. Myelin content and axonal density correlated strongly with MTR, T1, PD, and diffusion anisotropy, but only moderately with T2 and weakly with the apparent diffusion coefficient.Quantitative MR measures provide a promising tool to evaluate components of MS pathology that are clinically meaningful. Further studies are warranted to investigate the potential of new quantitative MR measures to enable a distinction between axonal loss and demyelination and between demyelinated and remyelinated lesions
Management of noma: practice competence and knowledge among healthcare workers in a rural district of Zambia
Variability in yellow leaf symptom expression caused by the Sugarcane yellow leaf virus and its seasonal influence in sugarcane
What is the quality of clinical practice guidelines accessible on the world wide web for the treatment of musculoskeletal conditions in physiotherapy?
Older Adults and Chronic Kidney Disease Decision Making by Primary Care Physicians: A Scholarly Review and Research Agenda
Detection and Quantification of Microparticles from Different Cellular Lineages Using Flow Cytometry. Evaluation of the Impact of Secreted Phospholipase A2 on Microparticle Assessment
Coupling Social Solidarity and Social Harmony in Hong Kong
Social solidarity, Social harmony, Resource exchange theory,