The Complexity of Vascular and Non-Vascular Complications of Diabetes: The Hong Kong Diabetes Registry

Diabetes is a complex disease characterized by chronic hyperglycemia and multiple phenotypes. In 1995, we used a doctor-nurse-clerk team and structured protocol to establish the Hong Kong Diabetes Registry in a quality improvement program. By 2009, we had accrued 2616 clinical events in 9588 Chinese type 2 diabetic patients with a follow-up duration of 6 years. The detailed phenotypes at enrollment and follow-up medications have allowed us to develop a series of risk equations to predict multiple endpoints with high sensitivity and specificity. In this prospective database, we were able to validate findings from clinical trials in real practice, confirm close links between cardiovascular and renal disease, and demonstrate the emerging importance of cancer as a leading cause of death. In addition to serving as a tool for risk stratification and quality assurance, ongoing data analysis of the registry also reveals secular changes in disease patterns and identifies unmet needs

Highly selective intramolecular carbene insertion into primary C-H bond of α-diazoacetamides mediated by a (p-cymene) ruthenium(II) carboxylate complex

Complex [(p-cymene)Ru(η 1-O 2CCF 3) 2(OH 2)] mediated transformation of α-diazoacetamides ArCH 2N(C(CH 3) 3)C(O)CHN 2 to result in carbene insertion into the primary C-H bond exclusively, with the γ-lactam products being isolated in up to 98% yield. This unexpected reaction is striking in view of the presence of usually more reactive sites such as secondary C-H bonds in the substrates. DFT calculations based on proposed Ru-carbene species provide insight into this unique selectivity. © 2012 American Chemical Society.link_to_subscribed_fulltex

Developing a prototype for a rapid demountable platform (RDP) : stage 2 of construction safety involving working at height for residential building repair and maintenance : draft final report of the CII-HK research project

Author name used in this publication: Michael C. H. YamAuthor name used in this publication: Albert W. K. KwokAuthor name used in this publication: Michael K. W. SiuAuthor name used in this publication: C. H. LiuAuthor name used in this publication: Edmond W. M. LamAuthor name used in this publication: Pete C. W. WongAuthor name used in this publication: W. C. LeeAuthor name used in this publication: Esther W. K. ChoyAuthor name used in this publication: C. H. Paul LoAuthor name used in this publication: Tracy S. K. ChungConstruction Industry Institute-Hong Kong Report, no. 14Other Versio