DETERMINATION OF PHARMACOKINETIC PARAMETERS FOR ATROPA BELLADONA EXTRACT CONTAINING ATROPINE IN TABLET DOSAGE FORM

ABSTRACTObjective: The present work was to formulate oral herbal tablets of Atropa belladona extract and also with pure atropine, further to determine thepharmacokinetic parameters and determine the dose frequency based on half-life.Methods: After the quantification of the extract through high-performance thin layer chromatography, tablets were prepared with extract andpure form of atropine through direct compression technique by varying the process and formulation parameters. The pre- and post-compressionparameters were evaluated for the formulated batches. In vivo studies using rabbit models of either sex were done and the various pharmacokineticparameters were reported.Results: The pharmacokinetic data obtained for pure and extract showed no significant difference in CConclusion: According to the results the Atropa belladonna extract and pure atropine tablets gave a t1/2 max at tmax of 2 hrs.of 3 hrs, representing that one tablet (equivalentto 0.021 mg of atropine) can be administered at every 3 hrs.Keywords: Atropine, Atropa belladonna, Herbal, Pharmacokinetics, Tablets

Effect of blood pressure on the retinal vasculature in a multi-ethnic Asian population

10.1038/hr.2009.130Hypertension Research3211975-98