28 research outputs found
Aryl hydrocarbon receptor signaling, toxicity, and gene expression responses to mono‐methylchrysenes
No full textLigand Binding of Safrole to Cytochrome P-450
No full textSafrole, a hepatocarcinogen, is converted by the microsomal mono-oxygenase system to a reactive intermediate which interacts with cytochrome P-450 to form a ligand complex. The formation of this complex is accompanied by loss of mono-oxygenase activity. The present study describes the interaction of the safrole reactive intermediate with microsomes from phenobarbital, 3-methylcholanthrene and safrole pretreated animals
Interaction of benzo[a]pyrene diol epoxide isomers with human serum albumin: Site specific characterisation of adducts and associated kinetics
No full textQuercetin Inhibits Benzo[a]Pyrene-Induced DNA Adducts in Human Hep G2 Cells by Altering Cytochrome P-450 1A1 Gene Expression
No full textThe Effect of 5,5?-Dithiobis(l-methyItetrazole) on Cytoplasmic Aldehyde Dehydrogenase and Its Implications for Cephalosporin-Alcohol Reactions
No full textCompetitive and noncompetitive N-methyl-D-aspartate antagonists protect dopaminergic and serotonergic neurotoxicity produced by methamphetamine in various brain regions
No full textMethamphetamine and MPTP: Similarities and Differences in Mechanisms of Neurotoxic Action
No full textL-519, a phenolic compound, inhibits metabolism of benzo(a)pyrene and mutagenesis induced by benzo(a)pyrene
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