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Utjecaj akarboze na katalitiÄke aktivnosti alanin aminotransferaze i aspartat aminotransferaze u jetri kontrolnih i dijabetiÄnih CBA miÅ”eva
The purpose of this study was to examine the short-term effects of diet containing 0.1% (m/m) of acarbose in standard laboratory chow on specific liver enzyme activities: alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in control and diabetic CBA mice. Diabetes was induced by intravenous injection of alloxan monohydrate in a dose of 75 mg kg-1 mouse body mass seven days before the treatment with acarbose. There were four groups of CBA mice in the experiment: control (C) mice (n = 6) and diabetic (D) mice (n = 8) fed standard chow; control (C/A-100) mice (n = 8) and diabetic (D/A-100) mice (n = 8) fed standard chow containing 0.1% acarbose. Diabetes induced the decrease of the ALT catalytic activities to 69.6% of control value. A similar level of decreased ALT catalytic activity was detected in the liver of control and diabetic mice fed with chow containing 0.1% acarbose. No changes in the specific and total activities of AST in the liver of the experimental groups were observed.Svrha ovog rada bila je ispitati kratkotrajni uÄinak 0.1% (m/m) akarboze u suhoj hrani na katalitiÄku koncentraciju specifiÄnih jetrenih enzima: alanin aminotransferaze (ALT) i aspartat aminotransferaze (AST) u jetri kontrolnih i dijabetiÄnih CBA miÅ”eva. Dijabetes je bio izazvan i.v. injekcijom aloksan-monohidrata u dozi od 75 mg kg -1 tjelesne mase miÅ”a sedam dana prije poÄetka ishrane s akarbozom. U pokusu su ispitane Äetiri skupine CBA miÅ”eva: kontrolna (C) (n = 6) i dijabetiÄna (D) (n = 8) skupina bile su sedam dana na standardnoj ishrani, te kontrolna (C / A ā 100) (n = 8) i dijabetiÄna (D / A-100) (n = 8) skupina koje su hranjene 0.1 % akarbozom umijeÅ”anom u standardnu hranu. U skupini D katalitiÄka koncentracija ALT-a bila je znaÄajno snižena u usporedbi s kontrolnom skupinom C. SliÄan pad katalitiÄke koncentracije ALT-a zabilježen je i u jetri kontrolnih i dijabetiÄnih miÅ”eva hranjenih suhom hranom u koju je bila umijeÅ”ana akarboza (0.1%). U ispitanim skupinama nisu zabilježene promjene u specifiÄnoj i ukupnoj aktivnosti AST-a