18,661 research outputs found
Antechamber facilitates loading and unloading of vacuum furnace
Antechamber facilitates the use of a furnace in which materials are heat treated in a high vacuum or a gas atmosphere. It has a high vacuum pumping system, a means for backfilling with a selected gas, an access door, glove ports, and a motor driven platform
Fluorescent carbon dioxide indicators
Over the last decade, fluorescence has become the dominant tool in biotechnology and medical imaging. These exciting advances have been underpinned by the advances in time-resolved techniques and instrumentation, probe design, chemical / biochemical sensing, coupled with our furthered knowledge in biology. Complementary volumes 9 and 10, Advanced Concepts of Fluorescence Sensing: Small Molecule Sensing and Advanced Concepts of Fluorescence Sensing: Macromolecular Sensing, aim to summarize the current state of the art in fluorescent sensing. For this reason, Drs. Geddes and Lakowicz have invited chapters, encompassing a broad range of fluorescence sensing techniques. Some chapters deal with small molecule sensors, such as for anions, cations, and CO2, while others summarize recent advances in protein-based and macromolecular sensors. The Editors have, however, not included DNA or RNA based sensing in this volume, as this were reviewed in Volume 7 and is to be the subject of a more detailed volume in the near future
VLASSICK: The VLA Sky Survey in the Central Kiloparsec
At a distance of 8 kpc, the center of our Galaxy is the nearest galactic
nucleus, and has been the subject of numerous key projects undertaken by great
observatories such as Chandra, Spitzer, and Herschel. However, there are still
no surveys of molecular gas properties in the Galactic center with less than
30" (1 pc) resolution. There is also no sensitive polarization survey of this
region, despite numerous nonthermal magnetic features apparently unique to the
central 300 parsecs. In this paper, we outline the potential the VLASS has to
fill this gap. We assess multiple considerations in observing the Galactic
center, and recommend a C-band survey with 10 micro-Jy continuum RMS and
sensitive to molecular gas with densities greater than 10^4 cm^{-3}, covering
17 square degrees in both DnC and CnB configurations ( resolution ~5"),
totaling 750 hours of observing time. Ultimately, we wish to note that the
upgraded VLA is not just optimized for fast continuum surveys, but has a
powerful correlator capable of simultaneously observing continuum emission and
dozens of molecular and recombination lines. This is an enormous strength that
should be fully exploited and highlighted by the VLASS, and which is ideally
suited for surveying the center of our Galaxy.Comment: 13 pages, 3 figures, a White Paper submitted to provide input in
planning the Very Large Array Sky Surve
A Comprehensive Radio and Optical Study of Abell 2256: Activity from an Infalling Group
Abell 2256 is a nearby (z~0.06), rich cluster of galaxies with fascinating
observed properties across a range of wavelengths. Long believed to represent a
cluster merger, recent X-ray and optical results have suggested that in
addition to the primary cluster and subcluster there is evidence for a third,
poorer system. We present wide-field, high sensitivity 1.4 GHz VLA radio
observations of Abell 2256 in conjunction with optical imaging and additional
spectroscopy. Over 40 cluster radio galaxies are identified, with optical
spectroscopy indicating the emission source (star formation or AGN) for most of
them. While the overall fraction of galaxies exhibiting radio emission is
consistent with a large sample of other nearby clusters, we find an increase in
the activity level of galaxies belonging to the third system (hereafter, the
``Group''). Specifically, the Group has relatively more star formation than
both the primary cluster and main subcluster. The position of the Group is also
coincident with the observed cluster radio relic. We suggest that the Group
recently (~0.3 Gyr) merged with the primary cluster and that this merger, not
the ongoing merger of the primary and the main subcluster, might be responsible
for many of the unusual radio properties of Abell 2256. Furthermore, the
greater star formation activity of the Group suggests that the infall of groups
is an important driver of galaxy evolution in clusters.Comment: 21 pages plus 13 JPEG figures; to appear in the Astronomical Journa
High-sensitivity troponin I concentrations are a marker of an advanced hypertrophic response and adverse outcomes in patients with aortic stenosis
Aims:
High-sensitivity cardiac troponin I (cTnI) assays hold promise in detecting the transition from hypertrophy to heart failure in aortic stenosis. We sought to investigate the mechanism for troponin release in patients with aortic stenosis and whether plasma cTnI concentrations are associated with long-term outcome.
Methods and results:
Plasma cTnI concentrations were measured in two patient cohorts using a high-sensitivity assay. First, in the Mechanism Cohort, 122 patients with aortic stenosis (median age 71, 67% male, aortic valve area 1.0 ± 0.4 cm2) underwent cardiovascular magnetic resonance and echocardiography to assess left ventricular (LV) myocardial mass, function, and fibrosis. The indexed LV mass and measures of replacement fibrosis (late gadolinium enhancement) were associated with cTnI concentrations independent of age, sex, coronary artery disease, aortic stenosis severity, and diastolic function. In the separate Outcome Cohort, 131 patients originally recruited into the Scottish Aortic Stenosis and Lipid Lowering Trial, Impact of REgression (SALTIRE) study, had long-term follow-up for the occurrence of aortic valve replacement (AVR) and cardiovascular deaths. Over a median follow-up of 10.6 years (1178 patient-years), 24 patients died from a cardiovascular cause and 60 patients had an AVR. Plasma cTnI concentrations were associated with AVR or cardiovascular death HR 1.77 (95% CI, 1.22 to 2.55) independent of age, sex, systolic ejection fraction, and aortic stenosis severity.
Conclusions:
In patients with aortic stenosis, plasma cTnI concentration is associated with advanced hypertrophy and replacement myocardial fibrosis as well as AVR or cardiovascular death
16S rRNA gene profiling and genome reconstruction reveal community metabolic interactions and prebiotic potential of medicinal herbs used in neurodegenerative disease and as nootropics.
The prebiotic potential of nervine herbal medicines has been scarcely studied. We therefore used anaerobic human fecal cultivation to investigate whether medicinal herbs commonly used as treatment in neurological health and disease in Ayurveda and other traditional systems of medicine modulate gut microbiota. Profiling of fecal cultures supplemented with either Kapikacchu, Gotu Kola, Bacopa/Brahmi, Shankhapushpi, Boswellia/Frankincense, Jatamansi, Bhringaraj, Guduchi, Ashwagandha or Shatavari by 16S rRNA sequencing revealed profound changes in diverse taxa. Principal coordinate analysis highlights that each herb drives the formation of unique microbial communities predicted to display unique metabolic potential. The relative abundance of approximately one-third of the 243 enumerated species was altered by all herbs. Additional species were impacted in an herb-specific manner. In this study, we combine genome reconstruction of sugar utilization and short chain fatty acid (SCFA) pathways encoded in the genomes of 216 profiled taxa with monosaccharide composition analysis of each medicinal herb by quantitative mass spectrometry to enhance the interpretation of resulting microbial communities and discern potential drivers of microbiota restructuring. Collectively, our results indicate that gut microbiota engage in both protein and glycan catabolism, providing amino acid and sugar substrates that are consumed by fermentative species. We identified taxa that are efficient amino acid fermenters and those capable of both amino acid and sugar fermentation. Herb-induced microbial communities are predicted to alter the relative abundance of taxa encoding SCFA (butyrate and propionate) pathways. Co-occurrence network analyses identified a large number of taxa pairs in medicinal herb cultures. Some of these pairs displayed related culture growth relationships in replicate cultures highlighting potential functional interactions among medicinal herb-induced taxa
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