230 research outputs found

    Legal Education in Crisis, and Why Law Libraries Are Doomed

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    The dual crises facing legal education - the economic crisis affecting both the job market and the pool of law school applicants, and the crisis of confidence in the ability of law schools and the ABA accreditation process to meet the needs of lawyers or society at large - have undermined the case for not only the autonomy, but the very existence, of law school libraries as we have known them. Legal education in the United States is about to undergo a long-term contraction, and law libraries will be among the first to go. A few law schools may abandon the traditional law library completely. Some law schools will see their libraries whittled away bit by bit as they attempt to answer “the Yirka Question” in the face of shrinking resources, reexamined priorities, and university centralization. What choices individual schools make will largely be driven by how they play the status game

    Out of the Jungle

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    Legal Education in Crisis, and Why Law Libraries Are Doomed

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    The dual crises facing legal education - the economic crisis affecting both the job market and the pool of law school applicants, and the crisis of confidence in the ability of law schools and the ABA accreditation process to meet the needs of lawyers or society at large - have undermined the case for not only the autonomy, but the very existence, of law school libraries as we have known them. Legal education in the United States is about to undergo a long-term contraction, and law libraries will be among the first to go. A few law schools may abandon the traditional law library completely. Some law schools will see their libraries whittled away bit by bit as they attempt to answer “the Yirka Question” in the face of shrinking resources, reexamined priorities, and university centralization. What choices individual schools make will largely be driven by how they play the status game

    Creating an Information Commons

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    Redefining Open Access for the Legal Information Market

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    The open access movement in legal scholarship, inasmuch as it is driven within the law library community over concerns about the rising cost of legal information, fails to address - and in fact diverts resources from - the real problem facing law libraries today: the soaring costs of nonscholarly, commercially published, practitioner-oriented legal publications. The current system of legal scholarly publishing - in student-edited journals and without meaningful peer review - does not face the pressures to increase prices common in the science and health disciplines. One solution to this problem is for law schools to redirect some of their resources - intellectual capital, reputation, and student labor - to publishing legal information for practitioners rather than legal scholars

    Best-practice IgM- and IgA-enriched immunoglobulin use in patients with sepsis

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    Background: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Despite treatment being in line with current guidelines, mortality remains high in those with septic shock. Intravenous immunoglobulins represent a promising therapy to modulate both the pro- and anti-inflammatory processes and can contribute to the elimination of pathogens. In this context, there is evidence of the benefits of immunoglobulin M (IgM)- and immunoglobulin A (IgA)-enriched immunoglobulin therapy for sepsis. This manuscript aims to summarize current relevant data to provide expert opinions on best practice for the use of an IgM- and IgA-enriched immunoglobulin (Pentaglobin) in adult patients with sepsis. Main text: Sepsis patients with hyperinflammation and patients with immunosuppression may benefit most from treatment with IgM- and IgA-enriched immunoglobulin (Pentaglobin). Patients with hyperinflammation present with phenotypes that manifest throughout the body, whilst the clinical characteristics of immunosuppression are less clear. Potential biomarkers for hyperinflammation include elevated procalcitonin, interleukin-6, endotoxin activity and C-reactive protein, although thresholds for these are not well-defined. Convenient biomarkers for identifying patients in a stage of immune-paralysis are still matter of debate, though human leukocyte antigen–antigen D related expression on monocytes, lymphocyte count and viral reactivation have been proposed. The timing of treatment is potentially more critical for treatment efficacy in patients with hyperinflammation compared with patients who are in an immunosuppressed stage. Due to the lack of evidence, definitive dosage recommendations for either population cannot be made, though we suggest that patients with hyperinflammation should receive an initial bolus at a rate of up to 0.6 mL (30 mg)/kg/h for 6 h followed by a continuous maintenance rate of 0.2 mL (10 mg)/kg/hour for ≥ 72 h (total dose ≥ 0.9 g/kg). For immunosuppressed patients, dosage is more conservative (0.2 mL [10 mg]/kg/h) for ≥ 72 h, without an initial bolus (total dose ≥ 0.72 g/kg). Conclusions: Two distinct populations that may benefit most from Pentaglobin therapy are described in this review. However, further clinical evidence is required to strengthen support for the recommendations given here regarding timing, duration and dosage of treatment

    On Folding and Twisting (and whatknot): towards a characterization of workspaces in syntax

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    Syntactic theory has traditionally adopted a constructivist approach, in which a set of atomic elements are manipulated by combinatory operations to yield derived, complex elements. Syntactic structure is thus seen as the result or discrete recursive combinatorics over lexical items which get assembled into phrases, which are themselves combined to form sentences. This view is common to European and American structuralism (e.g., Benveniste, 1971; Hockett, 1958) and different incarnations of generative grammar, transformational and non-transformational (Chomsky, 1956, 1995; and Kaplan & Bresnan, 1982; Gazdar, 1982). Since at least Uriagereka (2002), there has been some attention paid to the fact that syntactic operations must apply somewhere, particularly when copying and movement operations are considered. Contemporary syntactic theory has thus somewhat acknowledged the importance of formalizing aspects of the spaces in which elements are manipulated, but it is still a vastly underexplored area. In this paper we explore the consequences of conceptualizing syntax as a set of topological operations applying over spaces rather than over discrete elements. We argue that there are empirical advantages in such a view for the treatment of long-distance dependencies and cross-derivational dependencies: constraints on possible configurations emerge from the dynamics of the system.Comment: Manuscript. Do not cite without permission. Comments welcom
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