23 research outputs found
Acupuncture and Neurotrophin Modulation in Neurobiology of Acupuncture
The Western explanation for acupuncture effectiveness is based upon more than half a
century of basic and clinical research, which identified the activation of sensory system
and the subsequent activity-dependent regulation of neurotransmitters, neurohormones,
and several classes of neuromodulators as plausible mechanism for the acupuncture's
therapeutic properties. The regulation of neurotrophins' expression and
activity is one of the possible neurophysiological mechanisms underlying acupuncture's
effects on neuropathic pain, nerve injury, neurodegeneration, and even in the regulation
of gonadal functions. The present work will review the scientific literature produced
by a decade of investigations on the relationship between acupuncture and neurotrophins.
This scientific production and the current knowledge about the neural and
neurohormonal activity-dependent regulation of neurotrophin expression/action suggest
the existence of a link between the ability of acupuncture in regulating neural physiology
and its effects on the neurotrophic milieu in different disease state