Genome of the Avirulent Human-Infective Trypanosome—Trypanosoma rangeli

Background: Trypanosoma rangeli is a hemoflagellate protozoan parasite infecting humans and other wild and domestic mammals across Central and South America. It does not cause human disease, but it can be mistaken for the etiologic agent of Chagas disease, Trypanosoma cruzi. We have sequenced the T. rangeli genome to provide new tools for elucidating the distinct and intriguing biology of this species and the key pathways related to interaction with its arthropod and mammalian hosts.  Methodology/Principal Findings: The T. rangeli haploid genome is ,24 Mb in length, and is the smallest and least repetitive trypanosomatid genome sequenced thus far. This parasite genome has shorter subtelomeric sequences compared to those of T. cruzi and T. brucei; displays intraspecific karyotype variability and lacks minichromosomes. Of the predicted 7,613 protein coding sequences, functional annotations could be determined for 2,415, while 5,043 are hypothetical proteins, some with evidence of protein expression. 7,101 genes (93%) are shared with other trypanosomatids that infect humans. An ortholog of the dcl2 gene involved in the T. brucei RNAi pathway was found in T. rangeli, but the RNAi machinery is non-functional since the other genes in this pathway are pseudogenized. T. rangeli is highly susceptible to oxidative stress, a phenotype that may be explained by a smaller number of anti-oxidant defense enzymes and heatshock proteins.  Conclusions/Significance: Phylogenetic comparison of nuclear and mitochondrial genes indicates that T. rangeli and T. cruzi are equidistant from T. brucei. In addition to revealing new aspects of trypanosome co-evolution within the vertebrate and invertebrate hosts, comparative genomic analysis with pathogenic trypanosomatids provides valuable new information that can be further explored with the aim of developing better diagnostic tools and/or therapeutic targets

Risk Factors for Type 2 Diabetes Mellitus in Children

This study investigates risk factors for type 2 diabetes mellitus in a population of children in public schools, Fortaleza, CE, Brazil. A total of 727 children aged 6 to 11 years old from 12 schools were evaluated between March and June 2008. A form addressing socio-demographic data, body mass index, blood pressure, capillary blood glucose and waist circumference was applied. A total of 54.1% of the children were female, 21.7% were overweight, 6.6% were obese, 27% had central obesity, 6.2% showed altered capillary glucose, and 17% high blood pressure. In relation to risk factors, 53.4% presented no risk factors; 24.3% had at least one factor and 18.8% two risk factors. Nurses can intervene in schools through educational health programs encouraging the adoption of healthy habits and identifying children at risk of type 2 diabetes mellitus.El estudio tuvo como objetivo identificar factores de riesgo para diabetes mellitus tipo 2 en una población de niños de escuelas públicas de Fortaleza, Brasil. Fueron evaluadas 727 niños de 6 a 11 años, de 12 escuelas, en los meses de marzo a junio de 2008. Fue aplicado un formulario abordando aspectos sociodemográficos, índice de masa corporal, presión arterial, glucemia capilar y, circunferencia de la cintura. Fue identificado que 54,1% de los sujetos eran del sexo femenino, 21,7% tenían exceso de peso, 27% obesidad central, 6,2% alteraciones en la glucemia y 17,9% presión arterial elevada. En relación a los factores de riesgo, 53,4% no lo presentaban, 24,3% tenían por lo menos un factor y 18,8% dos factores. La enfermería puede actuar en las escuelas por medio de acciones de educación en salud, incentivando la adopción de hábitos de vida saludables y identificando niños con riesgo para diabetes mellitus tipo 2.O estudo teve como objetivo identificar fatores de risco para diabetes mellitus tipo 2 numa população de crianças de escolas públicas de Fortaleza, CE, Brasil. Foram avaliadas 727 crianças de 6 a 11 anos de 12 escolas, nos meses de março a junho de 2008. Foi aplicado formulário abordando aspectos sociodemográficos, índice de massa corporal, pressão arterial, glicemia capilar e circunferência da cintura. Dos sujeitos, 54,1% eram do sexo feminino, 21,7% tinham excesso de peso, 27% obesidade central, 6,2% alterações glicêmicas e 17,9% pressão arterial elevada. Em relação aos fatores de risco, 53,4% não apresentavam, 24,3% tinham pelo menos um fator e 18,8%, dois. A enfermagem pode atuar nas escolas por meio de ações de educação em saúde, incentivando a adoção de hábitos de vida saudáveis e na identificação de crianças com risco para diabetes mellitus tipo 2

Bigger, Better, Faster, More at the LHC

Multijet plus missing energy searches provide universal coverage for theories that have new colored particles that decay into a dark matter candidate and jets. These signals appear at the LHC further out on the missing energy tail than two-to-two scattering indicates. The simplicity of the searches at the LHC contrasts sharply with the Tevatron where more elaborate searches are necessary to separate signal from background. The searches presented in this article effectively distinguish signal from background for any theory where the LSP is a daughter or granddaughter of the pair-produced colored parent particle without ever having to consider missing energies less than 400 GeV.Comment: 26 pages, 8 Figures. Minor textual changes, typos fixed and references adde

Boletim and Arquivos: scientific communication until the creation of the Revista de Saúde Pública

ABSTRACT Based on historical references of scientific communication, we analyzed the issues of the Boletim do Instituto de Higiene de São Paulo and of the Arquivos da Faculdade de Higiene e Saúde Pública da Universidade de São Paulo. Published respectively from 1919 to 1946 and from 1947 to 1966, they totaled 120 issues. In their 48 years of publication, their goal was to disseminate the scientific production of the institution and to legitimize the theoretical debate of the field, in addition to supporting the public health intervention models, written by leading researchers of the institution and by contributors and managers in the field of public health. Both the Boletim and the Arquivos were recognized as scientific communication of national reference, and have laid the foundations for the creation of the Revista de Saúde Pública, in 1967

Trend analysis of the quality indicators for the Brazilian cervical cancer screening programme by region and state from 2006 to 2013

Quality indicators for the Brazilian cervical cancer screening programme can provide a perspective on its effectiveness in Brazilian macro-regions and states. The aim of this study was to perform a trend analysis of the cervical cancer screening program's quality indicators, according to Brazilian regions and states, from 2006 to 2013.(undefined)info:eu-repo/semantics/publishedVersio