Numerical study of slip effects on unsteady aysmmetric bioconvective nanofluid flow in a porous microchannel with an expanding/ contracting upper wall using Buongiorno’s model

In this paper, the unsteady fully developed forced convective flow of viscous incompressible biofluid that contains both nanoparticles and gyrotactic microorganisms in a horizontal micro-channel is studied. Buongiorno’s model is employed. The upper channel wall is either expanding or contracting and permeable and the lower wall is static and impermeable. The plate separation is therefore a function of time. Velocity, temperature, nano-particle species (mass) and motile micro-organism slip effects are taken into account at the upper wall. By using the appropriate similarity transformation for the velocity, temperature, nanoparticle volume fraction and motile microorganism density, the governing partial differential conservation equations are reduced to a set of similarity ordinary differential equations. These equations under prescribed boundary conditions are solved numerically using the Runge-Kutta-Fehlberg fourth-fifth order numerical quadrature in the MAPLE symbolic software. Excellent agreement between the present computations and solutions available in the literature (for special cases) is achieved. The key thermofluid parameters emerging are identified as Reynolds number, wall expansion ratio, Prandtl number, Brownian motion parameter, thermophoresis parameter, Lewis number, bioconvection Lewis number and bioconvection Péclet number. The influence of all these parameters on flow velocity, temperature, nano-particle volume fraction (concentration) and motile micro-organism density function is elaborated. Furthermore graphical solutions are included for skin friction, wall heat transfer rate, nano-particle mass transfer rate and micro-organism transfer rate. Increasing expansion ratio is observed to enhance temperatures and motile micro-organism density. Both nanoparticle volume fraction and microorganism increases with an increase in momentum slip. The dimensionless temperature and microorganism increases as wall expansion increases. Applications of the study arise in advanced nanomechanical bioconvection energy conversion devices, bio-nano-coolant deployment systems etc

Computation of melting dissipative magnetohydrodynamic nanofluid bioconvection with second order slip and variable thermophysical properties

This paper studies the combined effects of viscous dissipation, first and second order slip and variable transport properties on phase-change hydromagnetic bio-nanofluid convection flow from a stretching sheet. Nanoscale materials possess a much larger surface to volume ratio than bulk materials which significantly modifies their thermodynamic and thermal properties and lowers substantially the melting point. Gyrotactic non-magnetic micro-organisms are present in the nanofluid. The transport properties are assumed to be dependent on the concentration and temperature. Via appropriate similarity variables, the governing equation with boundary conditions are converted to nonlinear ordinary differential equations and are solved using the BVP4C subroutine in the symbolic software Matlab. The non-dimensional boundary value features a melting (phase change) parameter, temperature-dependent thermal conductive parameter, first as well as second order slip parameters, mass diffusivity parameter, Schmidt number, microorganism diffusivity parameter, bioconvection Schmidt number, magnetic body force parameter, Brownian motion and thermophoresis parameter. Extensive computations are visualized for the influence of these parameters. The present simulation is of relevance in the fabrication of bio-nanomaterials for bio-inspired fuel cells

Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy

Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe

Global variation in anastomosis and end colostomy formation following left-sided colorectal resection

Background End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection. Methods This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult patients undergoing elective or emergency left-sided colorectal resection within discrete 2-week windows. Countries were grouped into high-, middle- and low-income tertiles according to the United Nations Human Development Index (HDI). Factors associated with colostomy formation versus primary anastomosis were explored using a multilevel, multivariable logistic regression model. Results In total, 1635 patients from 242 hospitals in 57 countries undergoing left-sided colorectal resection were included: 113 (6·9 per cent) from low-HDI, 254 (15·5 per cent) from middle-HDI and 1268 (77·6 per cent) from high-HDI countries. There was a higher proportion of patients with perforated disease (57·5, 40·9 and 35·4 per cent; P < 0·001) and subsequent use of end colostomy (52·2, 24·8 and 18·9 per cent; P < 0·001) in low- compared with middle- and high-HDI settings. The association with colostomy use in low-HDI settings persisted (odds ratio (OR) 3·20, 95 per cent c.i. 1·35 to 7·57; P = 0·008) after risk adjustment for malignant disease (OR 2·34, 1·65 to 3·32; P < 0·001), emergency surgery (OR 4·08, 2·73 to 6·10; P < 0·001), time to operation at least 48 h (OR 1·99, 1·28 to 3·09; P = 0·002) and disease perforation (OR 4·00, 2·81 to 5·69; P < 0·001). Conclusion Global differences existed in the proportion of patients receiving end stomas after left-sided colorectal resection based on income, which went beyond case mix alone

Three-dimensional bioconvection nanofluid flow from a bi-axial stretching sheet with anisotropic slip

A theoretical study is presented for three-dimensional flow of bioconvection nanofluids containing gyrotactic microorganisms over a bi-axial stretching sheet. The effects of anisotropic slip, thermal jump and mass slip are considered in the mathematical model. Suitable similarity transformations are used to reduce the partial differential equation system into a nonlinear ordinary differential system. The transformed nonlinear ordinary differential equations with appropriate transformed boundary conditions are solved numerically with the bvp4c procedure in the symbolic software, MATLAB. The mathematical computations showed that an increase in Brownian motion parameter corresponds to a stronger thermophoretic force which encourages transport of nanoparticles from the hot bi-axial sheet to the quiescent fluid. This increases the nanoparticle volume fraction boundary layer. Fluid temperature and thermal boundary layer thickness are decreased with increasing stretching rate ratio of the bi-axial sheet. The present simulation is of relevance in the fabrication of bio-nanomaterials and thermally-enhanced media for bio-inspired fuel cells