Essence and Cause: Making Something Be What It Is

Aristotle frequently describes essence as a “cause” or “explanation”, thus ascribing to essence some sort of causal or explanatory role. This explanatory role is often explicated by scholars in terms of essence “making the thing be what it is” or “making it the very thing that it is”. I argue that this is problematic, at least on the assumption that “making” expresses an explanatory relation, since it violates certain formal features of explanation. I then consider whether Aristotle is vulnerable to this problem by examining the explanatory role of essence in Posterior Analytics and Metaphysics Z 17

Task planning and control synthesis for robotic manipulation in space applications

Space-based robotic systems for diagnosis, repair and assembly of systems will require new techniques of planning and manipulation to accomplish these complex tasks. Results of work in assembly task representation, discrete task planning, and control synthesis which provide a design environment for flexible assembly systems in manufacturing applications, and which extend to planning of manipulatiuon operations in unstructured environments are summarized. Assembly planning is carried out using the AND/OR graph representation which encompasses all possible partial orders of operations and may be used to plan assembly sequences. Discrete task planning uses the configuration map which facilitates search over a space of discrete operations parameters in sequential operations in order to achieve required goals in the space of bounded configuration sets

Conductance and persistent current in quasi-one-dimensional systems with grain boundaries: Effects of the strongly reflecting and columnar grains

We study mesoscopic transport in the Q1D wires and rings made of a 2D conductor of width W and length L >> W. Our aim is to compare an impurity-free conductor with grain boundaries with a grain-free conductor with impurity disorder. A single grain boundary is modeled as a set of the 2D-$\delta$-function-like barriers positioned equidistantly on a straight line and disorder is emulated by a large number of such straight lines, intersecting the conductor with random orientation in random positions. The impurity disorder is modeled by the 2D $\delta$-barriers with the randomly chosen positions and signs. The electron transmission through the wires is calculated by the scattering-matrix method, and the Landauer conductance is obtained. We calculate the persistent current in the rings threaded by magnetic flux: We incorporate into the scattering-matrix method the flux-dependent cyclic boundary conditions and we introduce a trick allowing to study the persistent currents in rings of almost realistic size. We mainly focus on the numerical results for L much larger than the electron mean-free path, when the transport is diffusive. If the grain boundaries are weakly reflecting, the systems with grain boundaries show the same (mean) conductance and the same (typical) persistent current as the systems with impurities, and the results also agree with the single-particle theories treating disorder as a white-noise-like potential. If the grain boundaries are strongly reflecting, the typical persistent currents can be about three times larger than the results of the white-noise-based theory, thus resembling the experimental results of Jariwala et al. (PRL 2001). We extend our study to the 3D conductors with columnar grains. We find that the persistent current exceeds the white-noise-based result by another one order of magnitude, similarly as in the experiment of Chandrasekhar et al. (PRL 1991)

Intensity correlations in electronic wave propagation in a disordered medium: the influence of spin-orbit scattering

We obtain explicit expressions for the correlation functions of transmission and reflection coefficients of coherent electronic waves propagating through a disordered quasi-one-dimensional medium with purely elastic diffusive scattering in the presence of spin-orbit interactions. We find in the metallic regime both large local intensity fluctuations and long-range correlations which ultimately lead to universal conductance fluctuations. We show that the main effect of spin-orbit scattering is to suppress both local and long-range intensity fluctuations by a universal symmetry factor 4. We use a scattering approach based on random transfer matrices.Comment: 15 pages, written in plain TeX, Preprint OUTP-93-42S (University of Oxford), to appear in Phys. Rev.

A new analysis of the GJ581 extrasolar planetary system

We have done a new analysis of the available observations for the GJ581 exoplanetary system. Today this system is controversial due to choices that can be done in the orbital determination. The main ones are the ocurrence of aliases and the additional bodies - the planets f and g - announced in Vogt et al. 2010. Any dynamical study of exoplanets requires the good knowledge of the orbital elements and the investigations involving the planet g are particularly interesting, since this body would lie in the Habitable Zone (HZ) of the star GJ581. This region,for this system, is very attractive of the dynamical point of view due to several resonances of two and three bodies present there. In this work, we investigate the conditions under which the planet g may exist. We stress the fact that the planet g is intimately related with the orbital elements of the planet d; more precisely, we conclude that it is not possible to disconnect its existence from the determination of the eccentricity of the planet d. Concerning the planet f, we have found one solution with period $\approx 450$ days, but we are judicious about any affirmation concernig this body because its signal is in the threshold of detection and the high period is in a spectral region where the ocorruence of aliases is very common. Besides, we outline some dynamical features of the habitable zone with the dynamical map and point out the role played by some resonances laying there.Comment: 12 pages, 9 figure

Equivalence of Fokker-Planck approach and non-linear σ\sigma-model for disordered wires in the unitary symmetry class

The exact solution of the Dorokhov-Mello-Pereyra-Kumar-equation for quasi one-dimensional disordered conductors in the unitary symmetry class is employed to calculate all $m$-point correlation functions by a generalization of the method of orthogonal polynomials. We obtain closed expressions for the first two conductance moments which are valid for the whole range of length scales from the metallic regime ($L\ll Nl$) to the insulating regime ($L\gg Nl$) and for arbitrary channel number. In the limit $N\to\infty$ (with $L/(Nl)=const.$) our expressions agree exactly with those of the non-linear $\sigma$-model derived from microscopic Hamiltonians.Comment: 9 pages, Revtex, one postscript figur

Changes In Nuclear Phenotypes Following Cold Shock In Panstrongylus Megistus (burmeister).

The nuclear phenotypes of Malpighian tubule epithelial cells of 5th instar male nymphs of the blood-sucking insect Panstrongylus megistus were studied immediately after a short (1 h) cold shock at 0 degrees C, and 10 and 30 days later. The objective was to compare the responses to a cold shock with those known to occur after hyperthermia in order to provide insight into the cellular effect of cold in this species. Nuclei which usually exhibited a conspicuous Y chromosome chromocenter were the most frequent phenotype in control and treated specimens. Phenotypes in which the heterochromatin was unravelled, or in which there was nuclear fusion or cell death were more abundant in the shocked specimens. Most of the changes detected have also been found in heat-shocked nymphs, except for nuclear fusion which generates giant nuclei and which appeared to be less effective or necessary than that elicited after heat shock. Since other studies showed that a short cold shock does not affect the survival of more than 14% of 5th instar nymphs of P. megistus with domestic habit and can induce tolerance to a prolonged cold shock, heat shock proteins proteins are probably the best candidates for effective protection of the cells and the insects from drastic damage caused by low temperature shocks.95893-

Quantum and Boltzmann transport in the quasi-one-dimensional wire with rough edges

We study quantum transport in Q1D wires made of a 2D conductor of width W and length L>>W. Our aim is to compare an impurity-free wire with rough edges with a smooth wire with impurity disorder. We calculate the electron transmission through the wires by the scattering-matrix method, and we find the Landauer conductance for a large ensemble of disordered wires. We study the impurity-free wire whose edges have a roughness correlation length comparable with the Fermi wave length. The mean resistance and inverse mean conductance 1/ are evaluated in dependence on L. For L -> 0 we observe the quasi-ballistic dependence 1/ = = 1/N_c + \rho_{qb} L/W, where 1/N_c is the fundamental contact resistance and \rho_{qb} is the quasi-ballistic resistivity. As L increases, we observe crossover to the diffusive dependence 1/ = = 1/N^{eff}_c + \rho_{dif} L/W, where \rho_{dif} is the resistivity and 1/N^{eff}_c is the effective contact resistance corresponding to the N^{eff}_c open channels. We find the universal results \rho_{qb}/\rho_{dif} = 0.6N_c and N^{eff}_c = 6 for N_c >> 1. As L exceeds the localization length \xi, the resistance shows onset of localization while the conductance shows the diffusive dependence 1/ = 1/N^{eff}_c + \rho_{dif} L/W up to L = 2\xi and the localization for L > 2\xi only. On the contrary, for the impurity disorder we find a standard diffusive behavior, namely 1/ = = 1/N_c + \rho_{dif} L/W for L < \xi. We also derive the wire conductivity from the semiclassical Boltzmann equation, and we compare the semiclassical electron mean-free path with the mean free path obtained from the quantum resistivity \rho_{dif}. They coincide for the impurity disorder, however, for the edge roughness they strongly differ, i.e., the diffusive transport is not semiclassical. It becomes semiclassical for the edge roughness with large correlation length

Mechanism of hyaluronan degradation by Streptococcus pneumoniae hyaluronate lyase - Structures of complexes with the substrate

Hyaluronate lyase enzymes degrade hyaluronan, the main polysaccharide component of the host connective tissues, predominantly into unsaturated disaccharide units, thereby destroying the normal connective tissue structure and exposing the tissue cells to various endo-and exogenous factors, including bacterial toxins. The crystal structures of Streptococcus pneumoniae hyaluronate lyase with tetra- and hexasaccharide hyaluronan substrates bound in the active site were determined at 1.52- and 2.0-Angstrom resolution, respectively. Hexasaccharide is the longest substrate segment that binds entirely within the active site of these enzymes. The enzyme residues responsible for substrate binding, positioning, catalysis, and product release were thereby identified and their specific roles characterized. The involvement of three residues in catalysis, Asn(349), His(399), and Tyro(408), is confirmed, and the details of proton acceptance and donation within the catalytic machinery are described. The mechanism of processivity of the enzyme is analyzed. The flexibility (allosteric) behavior of the enzyme may be understood in terms of the results of flexibility analysis of this protein, which identified two modes of motion that are also proposed to be involved in the hyaluronan degradation process. The first motion describes an opening and closing of the catalytic cleft located between the alpha- and beta-domains. The second motion demonstrates the mobility of a binding cleft, which may facilitate the binding of the negatively charged hyaluronan to the enzyme