105 research outputs found
Towards a novel carbon device for the treatment of sepsis
Sepsis is a systemic inflammatory response to infection in which the balance of pro- andanti-inflammatory mediators, which normally isolate and eliminate infection, is disrupted[1]. Gram negative sepsis is initiated by bacterial endotoxin release which activatesmacrophages and circulating monocytes to release TNF and IL-1ÎČ followed by IL-6 andother inflammatory cytokines [2]. As the disease progresses, an unregulatedinflammatory response results in, tissue injury, haematological dysfunction and organdysfunction. Severe sepsis, involving organ hypoperfusion may be further complicatedby hypotension that is unresponsive to adequate fluid replacement, resulting in septicshock and finally death [3].Despite improvements in anti-microbial and supportive therapies, sepsis remains asignificant cause of morbidity and mortality in ICUs worldwide [4]. The complexity ofprocesses mediating the progression of sepsis suggests that an extracorporeal devicecombining blood filtration with adsorption of a wide range of toxins, and inflammatorymediators offers the most comprehensive treatment strategy. However, no such deviceexists at present. A novel, uncoated, polymer pyrolysed synthetic carbon device isproposed which combines the superior adsorption properties of uncoated activatedcarbons with the capacity to manipulate porous structure for controlled adsorption oftarget plasma proteins and polypeptides [5]. Preliminary haemocompatibility andadsorptive capacity was assessed using a carbon matrix prototype
Decomposição e liberação de nutrientes do folhedo de espécies florestais nativas em plantios puros e mistos no sudeste da Bahia
TREE COMMUNITY COMPOSITION AND ABOVEGROUND BIOMASS IN A SECONDARY ATLANTIC FOREST, SERRA DO MAR STATE PARK, SĂO PAULO, BRAZIL
Caracterização de ecossistemas da mata atlĂąntica de tabuleiros por meio das formas de hĂșmus
Simulação dos efeitos das mudanças do uso da terra na dinùmica de carbono no solo na bacia do rio Piracicaba
Calibration of the century, apsim and ndicea models of decomposition and n mineralization of plant residues in the humid tropics
Nitrogen availability and forest productivity along a climosequence on Whiteface Mountain, New York
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