Central control of feeding

The rising rate of obesity in Western countries has led to intensified efforts to understand the molecular mechanisms underlying the central control of appetite and feeding behavior. This report highlights studies published from 2006 to 2008 revealing novel centrally acting anorexigenic hormones, the continued unraveling of complex hypothalamic intracellular signaling pathways that regulate feeding, and insights into leptin resistance

Resistance is Futile: Using Team Based Learning (TBL) to Teach Change and Create an Idea Champion Collective

Change is inevitable, yet resistance to change is common. Studies show that people will selectively focus on data that enables maintaining the status quo, even when overwhelming data indicates the need for change. Those who are resistant to change in their organizations often cope by ignoring the need for change or removing themselves from the organization, thus putting themselves and their organizations at a disadvantage. The ability to engage in and lead change is a practical skill set and, as such, can be taught. This workshop demonstrates how TBL is a solution to the challenge of teaching and facilitating change

Domain II of calmodulin is involved in activation of calcineurin

AbstractA family of mutant proteins related to calmodulin (CaM) has been produced using cDNA constructs in bacterial expression vectors. The new proteins contain amino acid substitutions in Ca2+-binding domains I, II, both I and II, or both II and IV. The calmodulin-like proteins have been characterized with respect to mobility on SDS-polyacrylamide gels, Ca2+-dependent enhancement of tyrosine fluorescence, and abilities to activate the CaM-dependent phosphatase calcineurin. These studies suggest that an intact Ca2+-binding domain II is minimally required for full activation of calcineurin

Diffuse Atomic and Molecular Gas near IC443

We present an analysis of results on absorption from Ca II, Ca I, K I, and the molecules CH+, CH, C2, and CN that probes gas interacting with the supernova remnant IC443. The eleven directions sample material across the visible nebula and beyond its eastern edge. Most of the neutral material, including the diatomic molecules, is associated with the ambient cloud detected via H I and CO emission. Analysis of excitation and chemistry yields gas densities that are typical of diffuse molecular gas. The low density gas probed by Ca II extends over a large range in velocities, from -120 to +80 km/s in the most extreme cases. This gas is distributed among several velocity components, unlike the situation for the shocked molecular clumps, whose emission occurs over much the same range but as very broad features. The extent of the high-velocity absorption suggests a shock velocity of 100 km/s for the expanding nebula.Comment: To be published in Ap