15 research outputs found
From damage response to action potentials: early evolution of neural and contractile modules in stem eukaryotes
CMF22 Is a Broadly Conserved Axonemal Protein and Is Required for Propulsive Motility in Trypanosoma brucei
The Pcdp1 complex coordinates the activity of dynein isoforms to produce wild-type ciliary motility
The C1d projection of the central apparatus includes Pcdp1 and is required for ciliary motility. A combination of structural and functional studies shows that C1d is required for coordination of dynein activity on specific doublets and differentially affects the activity of both the outer and inner dynein arms
Reactivation of flagellar motility in demembranated Leishmania reveals role of cAMP in flagellar wave reversal to ciliary waveform
Swimming with protists : perception, motility and flagellum assembly.
In unicellular and multicellular eukaryotes, fast cell motility and rapid movement of material over cell surfaces are often mediated by ciliary or flagellar beating. The conserved defining structure in most motile cilia and flagella is the '9+2' microtubule axoneme. Our general understanding of flagellum assembly and the regulation of flagellar motility has been led by results from seminal studies of flagellate protozoa and algae. Here we review recent work relating to various aspects of protist physiology and cell biology. In particular, we discuss energy metabolism in eukaryotic flagella, modifications to the canonical assembly pathway and flagellum function in parasite virulence