10 research outputs found
EphrinA/EphA signal facilitates insulin-like growth factor-I–induced myogenic differentiation through suppression of the Ras/extracellular signal–regulated kinase 1/2 cascade in myoblast cell lines
Insulin-like growth factor-I (IGF-I) activates not only the AKT pathway responsible for skeletal myogenesis but also the extracellular signal–regulated kinase (ERK) 1/2 cascade that inhibits myogenesis. The ephrinA/EphA signal facilitates IGF-I–induced myogenesis by inhibiting the Ras-ERK1/2 pathway via p120 Ras GTPase-activating protein