Five-Year Clinical Outcomes of a Polymer-Free Sirolimus-Eluting Stent Versus a Permanent Polymer Paclitaxel-Eluting Stent: Final Results of the Intracoronary Stenting and Angiographic Restenosis -Test Equivalence Between Two Drug-Eluting Stents (ISAR-TEST

Background: Limited evidence exists regarding the long-term performance of polymerfree (PF) drug-eluting stents (DES) in comparison to permanent polymer DES. This study investigated the 5-year efficacy and safety of a PF sirolimus-eluting stent (PF-SES) versus a permanent polymer paclitaxel-eluting stent (PES) in the setting of the Intracoronary Stenting and Angiographic Restenosis-Test Equivalence Between Two Drug-Eluting Stents (ISAR-TEST) randomized trial. Methods and Results: A total of 450 patients undergoing percutaneous coronary intervention were randomized to receive either PF-SES (Yukon, Translumina; n 5 225) or PES (Taxus, Boston Scientific; n 5 225). Clinical follow-up was performed to 5 years after enrollment. The endpoints were major adverse cardiac events (MACE), target lesion revascularization (TLR), the composite of death or any myocardial infarction (MI) and stent thrombosis (ST). The incidence of MACE at 5 years was 27.3% (57 patients) in the PF-SES group and 31.7