9,646 research outputs found
Simple Metals at High Pressure
In this lecture we review high-pressure phase transition sequences exhibited
by simple elements, looking at the examples of the main group I, II, IV, V, and
VI elements. General trends are established by analyzing the changes in
coordination number on compression. Experimentally found phase transitions and
crystal structures are discussed with a brief description of the present
theoretical picture.Comment: 22 pages, 4 figures, lecture notes for the lecture given at the Erice
course on High-Pressure Crystallography in June 2009, Sicily, Ital
Molecular motion in cell membranes: analytic study of fence-hindered random walks
A theoretical calculation is presented to describe the confined motion of
transmembrane molecules in cell membranes. The study is analytic, based on
Master equations for the probability of the molecules moving as random walkers,
and leads to explicit usable solutions including expressions for the molecular
mean square displacement and effective diffusion constants. One outcome is a
detailed understanding of the dependence of the time variation of the mean
square displacement on the initial placement of the molecule within the
confined region. How to use the calculations is illustrated by extracting
(confinement) compartment sizes from experimentally reported published
observations from single particle tracking experiments on the diffusion of
gold-tagged G-protein coupled mu-opioid receptors in the normal rat kidney cell
membrane, and by further comparing the analytical results to observations on
the diffusion of phospholipids, also in normal rat kidney cells.Comment: 10 pages, 5 figure
Effects of disorder in location and size of fence barriers on molecular motion in cell membranes
The effect of disorder in the energetic heights and in the physical locations
of fence barriers encountered by transmembrane molecules such as proteins and
lipids in their motion in cell membranes is studied theoretically. The
investigation takes as its starting point a recent analysis of a periodic
system with constant distances between barriers and constant values of barrier
heights, and employs effective medium theory to treat the disorder. The
calculations make possible, in principle, the extraction of confinement
parameters such as mean compartment sizes and mean intercompartmental
transition rates from experimentally reported published observations. The
analysis should be helpful both as an unusual application of effective medium
theory and as an investigation of observed molecular movements in cell
membranes.Comment: 9 pages, 5 figure
Key principle of the efficient running, swimming, and flying
Empirical observations indicate striking similarities among locomotion in
terrestrial animals, birds, and fish, but unifying physical grounds are
lacking. When applied to efficient locomotion, the analytical mechanics
principle of minimum action yields two patterns of mechanical similarity via
two explicit spatiotemporal coherent states. In steady locomotory modes, the
slow muscles determining maximal optimum speeds maintain universal intrinsic
muscular pressure. Otherwise, maximal speeds are due to constant mass-dependent
stiffness of fast muscles generating a uniform force field, exceeding
gravitation. Being coherent in displacements, velocities and forces, the body
appendages of animals are tuned to natural propagation frequency through the
state-dependent elastic muscle moduli.
Key words: variational principle of minimum action (04.20.Fy), locomotion
(87.19.ru), biomechanics (87.85.G-).Comment: Submitted to the Europhysical Letter
A general scheme for modeling gamma-ray burst prompt emission
We describe a general method for modeling gamma-ray burst prompt emission. We
find that for the burst to be produced via the synchrotron process unphysical
conditions are required -- the distance of the source from the center of the
explosion () must be larger than cm and the source
Lorentz factor \gta 10^3; for such a high Lorentz factor the deceleration
radius () is less than even if the number density of particles
in the surrounding medium is as small as cm. The result,
, is in contradiction with the early x-ray and optical
afterglow data. The synchrotron-self-Compton (SSC) process fares much better.
There is a large solution space for a typical GRB prompt emission to be
produced via the SSC process. The prompt optical emission accompanying the
burst is found to be very bright (\lta 14 mag; for ) in the SSC
model, which exceeds the observed flux (or upper limit) for most GRBs.
Continuous acceleration of electrons can significantly reduce the optical flux
and bring it down to the observed limits. (Abridged)Comment: Published in MNRAS Jan 2008, 56 page
Vaccination with viral vectors expressing NP, M1 and chimeric hemagglutinin induces broad protection against influenza virus challenge in mice
Seasonal influenza virus infections cause up to half a million deaths each year, the majority of which are older adults. Annual influenza virus vaccination protects against disease, but in the event of a mismatch between the circulating strain and vaccine strain, vaccine effectiveness is severely impacted. Therefore, there is an urgent need for a vaccine that induces broad protection against drifted seasonal and emerging pandemic influenza viruses. One approach in designing such a universal influenza virus vaccine is based on targeting conserved regions of the influenza virus hemagglutinin (HA), the major glycoprotein on the surface of the virus. Using chimeric hemagglutinin constructs (cHA), the immune system can be primed to produce antibody responses against the conserved immunosubdominant stalk region rather than the variable immunodominant head region. Furthermore, replication deficient viral vectors based on Chimpanzee Adenovirus (ChAdOx1) and Modified Vaccinia Ankara (MVA) virus expressing the influenza virus internal antigens, such as the nucleoprotein (NP) and the matrix protein 1 (M1), are capable of inducing strong influenza specific T cell responses in vaccinated individuals. This is another approach towards a broadly cross-protective influenza vaccine given the degree of conservation of NP and M1 across different influenza virus strains. Here, we combine these two platforms to evaluate the efficacy of a viral vector-based group 2 cHA intramuscular vaccination regime in mice to confer protection against influenza virus challenge of matched and mismatched group 2 strains. We show that vectored vaccines expressing both cHA and an NP-M1 fusion protein, in a prime-boost regimen (with different cHAs given at each vaccination), provide enhanced protection against H3N2 and H10N8 virus challenge when compared to vaccination with cHA alone or NP-M1 alone. The vaccine induced antibody responses against divergent HAs, NP, M1, and whole virus correlated with nature of administered vaccine and extent of protection seen across vaccinated groups. Influenza specific T cell responses were also increased in the vectored vaccines expressing both the cHA and the NP-M1 fusion protein. For further characterization, we are interested in looking at an optimal vaccination regimen, the possibility of an additional boost to induce cross-reactive antibodies, and the nature of the induced antibodies. Overall, these results improve our understanding of vaccination platforms capable of harnessing cellular and humoral immunity with the ultimate goal of designing a universal influenza vaccine
Numerical simulation of time delay interferometry for eLISA/NGO
eLISA/NGO is a new gravitational wave detection proposal with arm length of
10^6 km and one interferometer down-scaled from LISA. Just like LISA and
ASTROD-GW, in order to attain the requisite sensitivity for eLISA/NGO, laser
frequency noise must be suppressed to below the secondary noises such as the
optical path noise, acceleration noise etc. In previous papers, we have
performed the numerical simulation of the time delay interferometry (TDI) for
LISA and ASTROD-GW with one arm dysfunctional by using the CGC 2.7 ephemeris.
The results are well below their respective limits which the laser frequency
noise is required to be suppressed. In this paper, we follow the same procedure
to simulate the time delay interferometry numerically. To do this, we work out
a set of 1000-day optimized mission orbits of the eLISA/NGO spacecraft starting
at January 1st, 2021 using the CGC 2.7 ephemeris framework. We then use the
numerical method to calculate the residual optical path differences in the
second-generation TDI solutions as in our previous papers. The maximum path
length difference, for all configurations calculated, is below 13 mm (43 ps).
It is well below the limit which the laser frequency noise is required to be
suppressed for eLISA/NGO. We compare and discuss the resulting differences due
to the different arm lengths for various mission proposals -- eLISA/NGO, an
NGO-LISA-type mission with a nominal arm length of 2 x 10^6 km, LISA and
ASTROD-GW.Comment: 17 pages, 13 figures, 3 tables, minor changes in description to match
the accepted version of Classical and Quantum Gravity. arXiv admin note: text
overlap with arXiv:1102.496
Co-phasing the Large Binocular Telescope: status and performance of LBTI/PHASECam
The Large Binocular Telescope Interferometer is a NASA-funded nulling and
imaging instrument designed to coherently combine the two 8.4-m primary mirrors
of the LBT for high-sensitivity, high-contrast, and high-resolution infrared
imaging (1.5-13 um). PHASECam is LBTI's near-infrared camera used to measure
tip-tilt and phase variations between the two AO-corrected apertures and
provide high-angular resolution observations. We report on the status of the
system and describe its on-sky performance measured during the first semester
of 2014. With a spatial resolution equivalent to that of a 22.8-meter telescope
and the light-gathering power of single 11.8-meter mirror, the co-phased LBT
can be considered to be a forerunner of the next-generation extremely large
telescopes (ELT).Comment: 8 pages, 5 figures, SPIE Conference proceeding
Photochemistry of Furyl- and Thienyldiazomethanes: Spectroscopic Characterization of Triplet 3-Thienylcarbene
Photolysis (λ \u3e 543 nm) of 3-thienyldiazomethane (1), matrix isolated in Ar or N2 at 10 K, yields triplet 3-thienylcarbene (13) and α-thial-methylenecyclopropene (9). Carbene 13 was characterized by IR, UV/vis, and EPR spectroscopy. The conformational isomers of 3-thienylcarbene (s-E and s-Z) exhibit an unusually large difference in zero-field splitting parameters in the triplet EPR spectrum (|D/hc| = 0.508 cm–1, |E/hc| = 0.0554 cm–1; |D/hc| = 0.579 cm–1, |E/hc| = 0.0315 cm–1). Natural Bond Orbital (NBO) calculations reveal substantially differing spin densities in the 3-thienyl ring at the positions adjacent to the carbene center, which is one factor contributing to the large difference in D values. NBO calculations also reveal a stabilizing interaction between the sp orbital of the carbene carbon in the s-Z rotamer of 13 and the antibonding σ orbital between sulfur and the neighboring carbon—an interaction that is not observed in the s-E rotamer of 13. In contrast to the EPR spectra, the electronic absorption spectra of the rotamers of triplet 3-thienylcarbene (13) are indistinguishable under our experimental conditions. The carbene exhibits a weak electronic absorption in the visible spectrum (λmax = 467 nm) that is characteristic of triplet arylcarbenes. Although studies of 2-thienyldiazomethane (2), 3-furyldiazomethane (3), or 2-furyldiazomethane (4) provided further insight into the photochemical interconversions among C5H4S or C5H4O isomers, these studies did not lead to the spectroscopic detection of the corresponding triplet carbenes (2-thienylcarbene (11), 3-furylcarbene (23), or 2-furylcarbene (22), respectively)
- …