13 research outputs found
Renal medullary carcinoma
Renal medullary carcinoma (RMC) is a rare and aggressive form of non-clear cell kidney cancer that typically affects young adults and is almost exclusively associated with sickle cell trait. It has only been recognized in the last two decades and continues to be relatively poorly understood. Patients typically present with pain and hematuria and are often found to have metastatic disease at diagnosis. Prognosis is extremely poor, with a mean survival less than 1 year. Combination chemotherapy has been used with limited success. As we learn more about the genetics of the disease, targeted therapy is being attempted