16 research outputs found
Inhibition of growth and induction of apoptosis in human breast cancer by transfection of gef gene
Development of a dual-expression vector facilitated with selection-free PCR recombination cloning strategy
Indigenous Soil Microflora Versus Introduced Microorganisms in Subsurface Bioremediation
Transformation of pWWO in Rhizobium leguminosarum DPT to Engineer Toluene Degrading Ability for Rhizoremediation
A Novel Double-Enhanced Suicide Gene Therapy in a Colon Cancer Cell Line Mediated by Gef and Apoptin
Elimination of persistent vaccine bacteria of Salmonella enterica serovar Typhimurium in the guts of immunized mice by inducible expression of truncated YncE
Next-generation biocontainment systems for engineered organisms
The increasing use of engineered organisms for industrial, clinical, and environmental applications poses a growing risk of spreading hazardous biological entities into the environment. To address this biosafety issue, significant effort has been invested in creating ways to confine these organisms and transgenic materials. Emerging technologies in synthetic biology involving genetic circuit engineering, genome editing, and gene expression regulation have led to the development of novel biocontainment systems. In this perspective, we highlight recent advances in biocontainment and suggest a number of approaches for future development, which may be applied to overcome remaining challenges in safeguard implementation.111Nsciescopu