2,516 research outputs found
Students’ expectations from graduate studies in heritage (tourism) management
This article provides certain key aspects that might help to further develop academic heritage education. These have been discussed within brainstorming and round-table sessions carried out by World Heritage students at BTU Cottbus-Senftenberg. Important aspects regarding expectations, current issues and prospective career opportunities were selected after these sessions. With the idea of our International Master Programme in mind, the results of this work have been summarized to identify what makes a good focus to Heritage Studies and further strategies to improve this discipline. It was concluded that international and interdisciplinary approaches should serve as the basis to facilitate personal research interests, critical thinking, a sense of student community and how all these can be applied to a future professional career. External students, faculty members and heritage professionals are invited to join this debate
Kaposi's sarcoma-associated herpesvirus oncoprotein K13 protects against B cell receptor induced growth arrest and apoptosis through NF-κB activation
Kaposi's sarcoma-associated herpesvirus (KSHV) has been linked to the development of Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman's disease (MCD). We have characterized the role of KSHV-encoded viral FLICE inhibitory protein K13 in the modulation of anti-IgM induced growth arrest and apoptosis in B cells. We demonstrate that K13 protects WEHI 231, an immature B cell line, against anti-IgM induced growth arrest and apoptosis. The protective effect of K13 was associated with the activation of the NF-κB pathway and was deficient in its mutant, K13-58AAA, and a structural homolog, vFLIP E8, which lack NF-κB activity. K13 upregulated the expression of NF-κB subunit RelB and blocked the anti-IgM induced decline in c-Myc and rise in p27(Kip1) that have been associated with growth arrest and apoptosis. K13 also upregulated the expression of Mcl-1, an anti-apoptotic member of the Bcl2 family. Finally, K13 protected the mature B cell line Ramos against anti-IgM induced apoptosis through NF-κB activation. Inhibition of anti-IgM induced apoptosis by K13 may contribute to the development of KSHV-associated lymphoproliferative disorders
Effect of Temperature & Concentration on Dissolution Potentials of Sodium Chloride, Bromide & Iodide
344-34
Efcacy of sodium bicarbonate ingestion strategies for protecting blinding
Sodium bicarbonate (NaHCO3) is a widely researched ergogenic aid, but the optimal blinding strategy during randomised placebo-controlled trials is unknown. In this multi-study project, we aimed to determine the most efficacious ingestion strategy for blinding NaHCO3 research. During study one, 16 physically active adults tasted 0.3 g·kg-1 body mass NaHCO3 or 0.03 g·kg-1 body mass sodium chloride placebo treatments given in different flavour (orange, blackcurrant) and temperature (chilled, room temperature) solutions. They were required to guess which treatment they had received. During study two, 12 recreational athletes performed time-to-exhaustion (TTE) cycling trials (familiarisation, four experimental). Using a randomised, double-blind design, participants consumed 0.3 g·kg-1 body mass NaHCO3 or a placebo in 5 mL·kg-1 body mass chilled orange squash/water solutions or capsules and indicated what they believed they had received immediately after consumption, pre-TTE and post-TTE. In study one, NaHCO3 prepared in chilled orange squash resulted in the most unsure ratings (44%). In study two, NaHCO3 administered in capsules resulted in more unsure ratings (% here) than NaHCO3 (% here) given in solution, with differences in treatment assignment after consumption, epre-TTE, and post-TTE (all p<0.05). Administering NaHCO3 in capsules was the most efficacious blinding strategy which provides important implications for researchers conducting randomised placebo-controlled trials
Double-diffusive Hadley–Prats flow in a horizontal porous layer with a concentration based internal heat source
© 2017 Elsevier Inc. Double-diffusive Hadley–Prats flow with a concentration based heat source is investigated through linear and non-linear stability analyses. The resultant eigenvalue problems for both theories are solved numerically using Shooting and fourth order Runga–Kutta methods, with the critical thermal Rayleigh number being evaluated with respect to various flow governing parameters such as the magnitudes of the heat source and mass flow. It is observed, in the linear case, that an increase in the horizontal thermal Rayleigh number is stabilising for both positive and negative values of the solutal Rayleigh number. In the non-linear case, a destabilising effect is identified at higher mass flow rates. An increase in both the heat source and mass flow results in destabilisation
Dissolution Potentials of Sodium & Potassium Chlorides, Bromides & Iodides & of Ammonium Halides
561-56
Potencialidades do guandu como adubação verde em áreas cultivadas com cana-de-açúcar nos tabuleiros costeiros de Alagoas.
Grande parte da produção de cana-de-açúcar em Alagoas está concentrada nos tabuleiros costeiros, região litorânea com precipitação favorável ao desenvolvimento da cultura. Contudo, os solos de tabuleiros apresentam algumas limitações agrícolas referentes à baixa resistência mecânica a operações de preparo de solo, baixa fertilidade natural e de retenção de água e nutrientes. Os solos são caracterizados ainda por apresentarem uma alta coesão natural dos horizontes, o que dificulta a penetração e desenvolvimento radicular das plantas, a disponibilidade de água, a aeração e a absorção de nutrientes, podendo influenciar negativamente no desenvolvimento das culturas.bitstream/item/123063/1/Potencialidades-do-guandu.pd
Análise agroecológica de dois paradigmas modernos.
O presente estudo é uma revisão sobre a contribuição da agroecologia para o debate conservacionista e desenvolvimentista. O discurso tradicional da biologia da conservação traz um enfoque exclusivo nas unidades de conservação (UCs), prejudicando os esforços de preservação da matriz paisagística como todo. Por outro lado, o discurso pautado por alguns desenvolvimentistas é levado por uma diferente, mas não menos equivocada, corrente de pensamento que acredita na superioridade da produção agrícola intensiva frente à agricultura familiar. No Brasil, essa modernização precoce da agricultura teve consequências catastróficas para o pequeno produtor bem como levou o aumento da pobreza no campo e nas cidades. Através da crítica agroecológica, ambas as correntes, a conservacionista e a desenvolvimentista, se baseiam em preceitos falaciosos. Tendo em vista essas contradições, o estudo da agroecologia, mais especificamente o estudo dos sistemas agroflorestais diversificados, contribui para a conservação e traz uma maior responsabilidade social para a produção agrícola
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