Ultrasound attenuation and a P-B-T phase diagram of superfluid 3He in 98% aerogel

Longitudinal sound attenuation measurements in superfluid 3He in 98% aerogel were conducted at pressures between 14 and 33 bar and in magnetic fields up to 4.44 kG. The temperature dependence of the ultrasound attenuation in the A-like phase was determined for the entire superfluid region exploiting the field induced meta-stable A-like phase at the highest field. In the lower field, the A-B transition in aerogel was identified by a smooth jump in attenuation on both cooling and warming. Based on the transitions observed on warming, a phase diagram as a function of pressure (P), temperature (T) and magnetic field (B) is constructed. We find that the A-B phase boundary in aerogel recedes in a drastically different manner than in bulk in response to an increasing magnetic field. The implications of the observed phase diagram are discussed.Comment: 9 pages, 13 figures, accepted to PR

Control over phase separation and nucleation using a laser-tweezing potential

Control over the nucleation of new phases is highly desirable but elusive. Even though there is a long history of crystallization engineering by varying physicochemical parameters, controlling which polymorph crystallizes or whether a molecule crystallizes or forms an amorphous precipitate is still a poorly understood practice. Although there are now numerous examples of control using laser-induced nucleation, the absence of physical understanding is preventing progress. Here we show that the proximity of a liquid–liquid critical point or the corresponding binodal line can be used by a laser-tweezing potential to induce concentration gradients. A simple theoretical model shows that the stored electromagnetic energy of the laser beam produces a free-energy potential that forces phase separation or triggers the nucleation of a new phase. Experiments in a liquid mixture using a low-power laser diode confirm the effect. Phase separation and nucleation using a laser-tweezing potential explains the physics behind non-photochemical laser-induced nucleation and suggests new ways of manipulating matter

High frequency sound in superfluid 3He-B

We present measurements of the absolute phase velocity of transverse and longitudinal sound in superfluid 3He-B at low temperature, extending from the imaginary squashing mode to near pair-breaking. Changes in the transverse phase velocity near pair-breaking have been explained in terms of an order parameter collective mode that arises from f-wave pairing interactions, the so-called J=4- mode. Using these measurements, we establish lower bounds on the energy gap in the B-phase. Measurement of attenuation of longitudinal sound at low temperature and energies far above the pair-breaking threshold, are in agreement with the lower bounds set on pair-breaking. Finally, we discuss our estimations for the strength of the f-wave pairing interactions and the Fermi liquid parameter, F4s.Comment: 15 pages, 8 figures, accepted to J. Low Temp. Phy

Near Resonant Spatial Images of Confined Bose-Einstein Condensates in the '4D' Magnetic Bottle

We present quantitative measurements of the spatial density profile of Bose-Einstein condensates of sodium atoms confined in a new '4D' magnetic bottle. The condensates are imaged in transmission with near resonant laser light. We demonstrate that the Thomas-Fermi surface of a condensate can be determined to better than 1%. More generally, we obtain excellent agreement with mean-field theory. We conclude that precision measurements of atomic scattering lengths and interactions between phase separated cold atoms in a harmonic trap can be measured with high precision using this method.Comment: 15 pages, 3 figures. Submitted 10/30/97, accepted for publication in Phys. Rev. A Rapid Com

Favorable prognostic value of SOCS2 and IGF-I in breast cancer

<p>Abstract</p> <p>Background</p> <p>Suppressor of cytokine signaling (SOCS) proteins comprise a protein family, which has initially been described as STAT induced inhibitors of the Jak/Stat pathway. Recent in vivo and in vitro studies suggest that SOCS proteins are also implicated in cancer. The STAT5 induced IGF-I acts as an endocrine and para/autocrine growth and differentiation factor in mammary gland development. Whereas high levels of circulating IGF-I have been associated with increased cancer risk, the role of autocrine acting IGF-I is less clear. The present study is aimed to elucidate the clinicopathological features associated with SOCS1, SOCS2, SOCS3, CIS and IGF-I expression in breast cancer.</p> <p>Methods</p> <p>We determined the mRNA expression levels of SOCS1, SOCS2, SOCS3, CIS and IGF-I in 89 primary breast cancers by reverse transcriptase PCR. SOCS2 protein expression was further evaluated by immuno-blot and immunohistochemistry.</p> <p>Results</p> <p>SOCS2 expression inversely correlated with histopathological grade and ER positive tumors exhibited higher SOCS2 levels. Patients with high SOCS2 expression lived significantly longer (108.7 vs. 77.7 months; P = 0.015) and high SOCS2 expression proved to be an independent predictor for good prognosis (HR = 0.45, 95% CI 0.23 – 0.91, P = 0.026). In analogy to SOCS2, high IGF-I expression was an independent predictor for good prognosis in the entire patient cohort. In the subgroup of patients with lymph-node negative disease, high IGF-I was a strong predictor for favorable outcome in terms of overall survival and relapse free survival (HR = 0.075, 95% CI 0.014 – 0.388, P = 0.002).</p> <p>Conclusion</p> <p>This is the first report on the favorable prognostic value of high SOCS2 expression in primary mammary carcinomas. Furthermore a strong association of high IGF-I expression levels with good prognosis was observed especially in lymph-node negative patients. Our results suggest that high expression of the STAT5 target genes SOCS2 and IGF-I is a feature of differentiated and less malignant tumors.</p