Histochemical and Ultrastructural Study of Clara Cell Granules in the Guinea Pig

Histochemical studies using light and electron microscopes were undertaken to see what chemical components make up the Clara cell granules in guinea pig lung. Light microscopically, it was suggested that they may contain a variable amount of proteins, carbohydrates, and phospholipids. On the other hand, electron microscopic examination with digestive treatment with pepsin as well as chloroform-methanol clearly demonstrated that the main component of the crystalline granules of the guinea pig Clara cells was the proteins. It was, therefore, concluded that Clara cell granules are complex compounds made up mainly of proteins with small amounts of carbohydrates and phospholipids

Epithelial Mucinosis in Exophytic Endobronchial Squamous Cell Carcinoma

Three cases of exophytic squamous cell carcinoma of the lung in which an unusual epithelial change with intercellular mucin deposit; namely epithelial mucinosis, was present in variable degree are reported here. As either exophytic variant of lung carcinomas or its mucinotic change is rare, the general concept of this lung carcinomas is summarized and the significance of epithelial mucinosis is discussed

Membranous Fibrosis of the Lung

Membranous fibrosis of the lung depicts a morphological feature of the fibrous tissue which covers alveolar duct walls. Membranous sheets of fibrous tissue usually bridge and obstruct the mouths of alveoli, and attach only at the tips of the septa; i.e., the alveolar duct walls, and often provoke a collapse of alveolar spaces. There seem to be two types of membranous fibrosis. The first type is, in fact, a fibrous replacement of pre-existing hyaline membrane, while the second is a de novo formation of membranous fibrous tissue which has little or no preceding hyaline membrane. We consider that both of these changes result from damage to the alveolar duct walls and may constitute forms of the fibrosing alveolar ductitis syndrome. Recognition of this type of fibrosis gives us a better understanding of the morphogenesis of so-called diffuse alveolar damage

Intraluminal (Intra-alveolar) Diffuse Fibrosis of the Lung

The present communication describes the morphology, etiology and mechanisms of intraluminal (or intra-alveolar) diffuse fibrosis of the lungs. Pulmonary fibrosis is the end-stage of tissue injury in the lungs and is usually non-specific. The determination of its original cause is difficult, but intraluminal diffuse fibrosis with loose stroma is quite unique and characteristic. In addition to paraquat lungs, we herein show that radiation pneumonitis, infarction, and some forms of bronchiolitis obliterans may cause this type of fibrosis. It is speculated that intraluminal diffuse fibrosis is the result of severe alveolar epithelial damage occurring diffusely and continuously, followed by edema and organization of the alveoli

Six Years at the Law School in Retrospect

特集　法科大学院での法曹養成と実務家教員の役割最終講義の日2010年3月25日/場所神奈川大学法務研究科24号館1