A nonhomogeneous boundary value problem in mass transfer theory

We prove a uniqueness result of solutions for a system of PDEs of Monge-Kantorovich type arising in problems of mass transfer theory. The results are obtained under very mild regularity assumptions both on the reference set $\Omega\subset\mathbf{R}^n$, and on the (possibly asymmetric) norm defined in $\Omega$. In the special case when $\Omega$ is endowed with the Euclidean metric, our results provide a complete description of the stationary solutions to the tray table problem in granular matter theory.Comment: 22 pages, 2 figure

A chemogenomic screening identifies CK2 as a target for pro-senescence therapy in PTEN-deficient tumours

Enhancement of cellular senescence in tumours triggers a stable cell growth arrest and activation of an antitumour immune response that can be exploited for cancer therapy. Currently, there are only a limited number of targeted therapies that act by increasing senescence in cancers, but the majority of them are not selective and also target healthy cells. Here we developed a chemogenomic screening to identify compounds that enhance senescence in PTEN-deficient cells without affecting normal cells. By using this approach, we identified casein kinase 2 (CK2) as a pro-senescent target. Mechanistically, we show that Pten loss increases CK2 levels by activating STAT3. CK2 upregulation in Pten null tumours affects the stability of Pml, an essential regulator of senescence. However, CK2 inhibition stabilizes Pml levels enhancing senescence in Pten null tumours. Taken together, our screening strategy has identified a novel STAT3-CK2-PML network that can be targeted for pro-senescence therapy for cancer

Giant sandbur (Cenchrus palmeri, Poaceae) new for Arizona and the United States

Volume: 2013-91Start Page: 1End Page:

Ajo Peak to Tinajas Altas: Flora of southwestern Arizona: Part 8, Eudicots: Acanthaceae–Apocynaceae

Volume: 2014-85Start Page: 1End Page: 7

Ajo Peak to Tinajas Altas: A flora of southwestern Arizona. Part 6. Poaceae – grass family

Volume: 2014-35Start Page: 1End Page: 13

Ajo Peak to Tinajas Altas: A flora of southwestern Arizona. Part 12. Eudicots: Campanulaceae to Cucurbitaceae

Volume: 2015-21Start Page: 1End Page: 3

Ajo Peak to Tinajas Altas: A flora of southwestern Arizona. Part 11. Eudicots: Brassicaceae and Burseraceae

Volume: 2015-6Start Page: 1End Page: 4