Measuring antibiotic availability and use in 20 low- and middle-income countries

Objective To assess antibiotic availability and use in health facilities in low- and middle-income countries, using the service provision assessment and service availability and readiness assessment surveys. Methods We obtained data on antibiotic availability at 13 561 health facilities in 13 service provision assessment and 8 service availability and readiness assessment surveys. In 10 service provision assessment surveys, child consultations with health-care providers were observed, giving data on antibiotic use in 22 699 children. Antibiotics were classified as access, watch or reserve, according to the World Health Organization’s AWaRe categories. The percentage of health-care facilities across countries with specific antibiotics available and the proportion of children receiving antibiotics for key clinical syndromes were estimated. Findings The surveys assessed the availability of 27 antibiotics (19 access, 7 watch, 1 unclassified). Co-trimoxazole and metronidazole were most widely available, being in stock at 89.5% (interquartile range, IQR: 11.6%) and 87.1% (IQR: 15.9%) of health facilities, respectively. In contrast, 17 other access and watch antibiotics were stocked, by fewer than a median of 50% of facilities. Of the 22 699 children observed, 60.1% (13 638) were prescribed antibiotics (mostly co-trimoxazole or amoxicillin). Children with respiratory conditions were most often prescribed antibiotics (76.1%; 8972/11 796) followed by undifferentiated fever (50.1%; 760/1518), diarrhoea (45.7%; 1293/2832) and malaria (30.3%; 352/1160). Conclusion Routine health facility surveys provided a valuable data source on the availability and use of antibiotics in low- and middle-income countries. Many access antibiotics were unavailable in a majority of most health-care facilities

A gas-rich AGN near the centre of a galaxy cluster at z ~ 1.4

The formation of the first virialized structures in overdensities dates back to ~9 Gyr ago, i.e. in the redshift range z ~ 1.4 - 1.6. Some models of structure formation predict that the star formation activity in clusters was high at that epoch, implying large reservoirs of cold molecular gas. Aiming at finding a trace of this expected high molecular gas content in primeval clusters, we searched for the 12CO(2-1) line emission in the most luminous active galactic nucleus (AGN) of the cluster around the radio galaxy 7C 1756+6520 at z ~ 1.4, one of the farthest spectroscopic confirmed clusters. This AGN, called AGN.1317, is located in the neighbourhood of the central radio galaxy at a projected distance of ~780 kpc. The IRAM Plateau de Bure Interferometer was used to investigate the molecular gas quantity in AGN.1317, observing the 12CO(2-1) emission line. We detect CO emission in an AGN belonging to a galaxy cluster at z ~ 1.4. We measured a molecular gas mass of 1.1 x 10^10 Msun, comparable to that found in submillimeter galaxies. In optical images, AGN.1317 does not seem to be part of a galaxy interaction or merger.We also derived the nearly instantaneous star formation rate (SFR) from Halpha flux obtaining a SFR ~65 Msun/yr. This suggests that AGN.1317 is actively forming stars and will exhaust its reservoir of cold gas in ~0.2-1.0 Gyr.Comment: 5 pages, 3 figures, accepted for publication in Astronomy & Astrophysic

Conceptual-level evaluation of a variable stiffness skin for a morphing wing leading edge

A morphing leading edge produces a continuous aerodynamic surface that has no gaps between the moving and fixed parts. The continuous seamless shape has the potential to reduce drag, compared to conventional devices, such as slats that produce a discrete aerofoil shape change. However, the morphing leading edge has to achieve the required target shape by deforming from the baseline shape under the aerodynamic loads. In this paper, a conceptual-level method is proposed to evaluate the morphing leading edge structure. The feasibility of the skin design is validated by checking the failure index of the composite when the morphing leading edge undergoes the shape change. The stiffness of the morphing leading edge skin is spatially varied using variable lamina angles, and comparisons to the skin with constant stiffness are made to highlight its potential to reduce the actuation forces. The structural analysis is performed using a two-level structural optimisation scheme. The first level optimisation is applied to find the optimised structural proper- ties of the leading edge skin and the associated actuation forces. The structural properties of the skin are given as a stiffness distribution, which is controlled by a B spline interpolation function. In the second level, the design solution of the skin is investigated. The skin is assumed to be made of variable stiffness composite. The stack sequence of the composite is optimised element-by-element to match the target stiffness. A failure criterion is employed to obtain the failure index when the leading edge is actuated from the baseline shape to the target shape. Test cases are given to demonstrate that the optimisation scheme is able to provide the stiffness distribution of the leading edge skin and the actuation forces can be reduced by using a spatially variable stiffness skin

Serotonin-mediated tuning of human helper T cell responsiveness to the chemokine CXCL12

In addition to its role as neurotransmitter, serotonin (5-HT) is an important modulator of inflammation and immunity. Here, we report novel findings suggesting a 5-HT involvement in T cell migration. In particular, we show that 5-HT tunes the responsiveness of human T lymphocytes to the broadly expressed chemokine CXCL12 in transwell migration assays. By real-time PCR, western blot analysis and electrophysiological patch clamp experiments, we demonstrate that the type 3 5-HT receptor (5-HT 3) is functionally expressed in human primary T cells. In addition, specific 5-HT 3 receptor agonists selectively decrease T cell migration towards gradients of CXCL12 but not of inflammatory chemokines, such as CCL2 and CCL5. In transmigration experiments, 5-HT 3 receptor stimulation reverts the inhibitory effect of endothelial-bound CXCL12 on T cell migration. Our data suggest that the reduced T cell responsiveness to CXCL12 induced by 5-HT may occur to facilitate T cell extravasation and migration into inflamed tissues

Human-robot coexistence and interaction in open industrial cells

Recent research results on human\u2013robot interaction and collaborative robotics are leaving behind the traditional paradigm of robots living in a separated space inside safety cages, allowing humans and robot to work together for completing an increasing number of complex industrial tasks. In this context, safety of the human operator is a main concern. In this paper, we present a framework for ensuring human safety in a robotic cell that allows human\u2013robot coexistence and dependable interaction. The framework is based on a layered control architecture that exploits an effective algorithm for online monitoring of relative human\u2013robot distance using depth sensors. This method allows to modify in real time the robot behavior depending on the user position, without limiting the operative robot workspace in a too conservative way. In order to guarantee redundancy and diversity at the safety level, additional certified laser scanners monitor human\u2013robot proximity in the cell and safe communication protocols and logical units are used for the smooth integration with an industrial software for safe low-level robot control. The implemented concept includes a smart human-machine interface to support in-process collaborative activities and for a contactless interaction with gesture recognition of operator commands. Coexistence and interaction are illustrated and tested in an industrial cell, in which a robot moves a tool that measures the quality of a polished metallic part while the operator performs a close evaluation of the same workpiece

Smoking, haptoglobin and fertility in humans

A prospective study on two samples of consecutive puerperae (total n° 667) from two populations has been carried out in order to investigate the possible effect of smoking habit on relationship between fertility and haptoglobin phenotype

Distributed field plate effects in split-gate trench MOSFETs

Fast electric transients can cause distributed effects inside trench MOSFETs possibly resulting in device failure. A new test structure to study those distributed effects, combined with a new Transmission-Line Pulse (TLP) setup, is presented. On-wafer TLP measurements are performed and combined with TCAD and SPICE simulations to predict the space and time evolution of the field plate potential during transients.</p

The Gaia-ESO Survey: N-body modelling of the Gamma Velorum cluster

The Gaia-ESO Survey has recently unveiled the complex kinematic signature of the Gamma Velorum cluster: this cluster is composed of two kinematically distinct populations (hereafter, population A and B), showing two different velocity dispersions and a relative ~2 km s^-1 radial velocity (RV) shift. In this paper, we propose that the two populations of the Gamma Velorum cluster originate from two different sub-clusters, born from the same parent molecular cloud. We investigate this possibility by means of direct-summation N-body simulations. Our scenario is able to reproduce not only the RV shift and the different velocity dispersions, but also the different centroid (~0.5 pc), the different spatial concentration and the different line-of-sight distance (~5 pc) of the two populations. The observed 1-2 Myr age difference between the two populations is also naturally explained by our scenario, in which the two sub-clusters formed in two slightly different star formation episodes. Our simulations suggest that population B is strongly supervirial, while population A is close to virial equilibrium. We discuss the implications of our models for the formation of young star clusters and OB associations in the Milky Way.Comment: 12 pages, 7 figures, 2 tables, Astronomy and Astrophysics, in pres

The Gaia-ESO Survey: the selection function of the Milky Way field stars

The Gaia-ESO Survey was designed to target all major Galactic components (i.e., bulge, thin and thick discs, halo and clusters), with the goal of constraining the chemical and dynamical evolution of the Milky Way. This paper presents the methodology and considerations that drive the selection of the targeted, allocated and successfully observed Milky Way field stars. The detailed understanding of the survey construction, specifically the influence of target selection criteria on observed Milky Way field stars is required in order to analyse and interpret the survey data correctly. We present the target selection process for the Milky Way field stars observed with VLT/FLAMES and provide the weights that characterise the survey target selection. The weights can be used to account for the selection effects in the Gaia-ESO Survey data for scientific studies. We provide a couple of simple examples to highlight the necessity of including such information in studies of the stellar populations in the Milky Way.Comment: 18 pages, 19 figures, Accepted for publication in MNRAS (April 25, 2016

Gas accretion as the origin of chemical abundance gradients in distant galaxies

It has recently been suggested that galaxies in the early Universe can grow through the accretion of cold gas, and that this may have been the main driver of star formation and stellar mass growth. Because the cold gas is essentially primordial, it has a very low abundance of elements heavier than helium (metallicity). As it is funneled to the centre of a galaxy, it will lead the central gas having an overall lower metallicity than gas further from the centre, because the gas further out has been enriched by supernovae and stellar winds, and not diluted by the primordial gas. Here we report chemical abundances across three rotationally-supported star-forming galaxies at z~3, only 2 Gyr after the Big Bang. We find an 'inverse' gradient, with the central, star forming regions having a lower metallicity than less active ones, opposite to what is seen in local galaxies. We conclude that the central gas has been diluted by the accretion of primordial gas, as predicted by 'cold flow' models.Comment: To Appear in Nature Oct 14, 2010; Supplementary Information included her