BSAVA Formulary: Your questions answered

A new edition of the BSAVA Small Animal Formulary has been published. Ian Ramsey explains what is in and what is out of this new version

Identification of the Early Fermi LAT Gamma-Ray Bright Objects with Extragalactic VLBI sources

A list of 205 gamma-ray strong objects was reported recently as a result of a 3-month integration with the Large Area Telescope on board the Fermi Gamma-Ray Space Telescope. We attempted identification of these objects, cross-correlating the gamma-ray positions with VLBI positions of a large all-sky sample of extragalactic radio sources selected on the basis of their parsec-scale flux density. The original associations reported by the Fermi team are confirmed and six new identifications are suggested. A Monte-Carlo analysis shows that the fraction of chance associations in our analysis is less than 5 per cent, and confirms that the vast majority of gamma-ray bright extragalactic sources are radio loud blazars with strong parsec-scale jets. A correlation between the parsec-scale radio and gamma-ray flux is supported by our analysis of a complete VLBI flux-density-limited sample of extragalactic jets. The effectiveness of using a VLBI catalog to find associations between gamma-ray detections and compact extragalactic radio sources, especially near the Galactic plane, is demonstrated. It is suggested that VLBI catalogs should be used for future identification of Fermi LAT objects.Comment: 5 pages, 4 figures, 1 table, accepted by the Astrophysical Journal Letters; minor corrections to the text are made, one panel is added to Figure 1; full table 1 in electronic form can be extracted from the preprint sourc

Sequestration of Martian CO2 by mineral carbonation

Carbonation is the water-mediated replacement of silicate minerals, such as olivine, by carbonate, and is commonplace in the Earth’s crust. This reaction can remove significant quantities of CO2 from the atmosphere and store it over geological timescales. Here we present the first direct evidence for CO2 sequestration and storage on Mars by mineral carbonation. Electron beam imaging and analysis show that olivine and a plagioclase feldspar-rich mesostasis in the Lafayette meteorite have been replaced by carbonate. The susceptibility of olivine to replacement was enhanced by the presence of smectite veins along which CO2-rich fluids gained access to grain interiors. Lafayette was partially carbonated during the Amazonian, when liquid water was available intermittently and atmospheric CO2 concentrations were close to their present-day values. Earlier in Mars’ history, when the planet had a much thicker atmosphere and an active hydrosphere, carbonation is likely to have been an effective mechanism for sequestration of CO2

Globalization, the ambivalence of European integration and the possibilities for a post-disciplinary EU studies

Using the work of Manuel Castells as a starting point, this article explores the ambivalent relationship between globalization and European integration and the variety of ways in which the mainstream political science of the EU has attempted to deal with this issue. The analysis here suggests that various 'mainstreaming' disciplinary norms induce types of work that fail to address fully the somewhat paradoxical and counter-intuitive range of possible relationships between globalization and European integration. The article explores critically four possible analytical ways out of this paradox—abandonment of the concept of globalization, the development of definition precision in globalization studies, the reorientation of work to focus on globalization as discourse, and inter- and post-disciplinarity. The argument suggests that orthodox discussions of the relationship require a notion of social geography that sits at odds with much of the literature on globalization and while greater dialogue between disciplines is to be welcomed, a series of profound epistemological questions need to be confronted if studies of the interplay between global and social process are to be liberated from their disciplinary chains

An evaluation of enteral nutrition practices and nutritional provision in children during the entire length of stay in critical care

<b>Background</b> Provision of optimal nutrition in children in critical care is often challenging. This study evaluated exclusive enteral nutrition (EN) provision practices and explored predictors of energy intake and delay of EN advancement in critically ill children.<p></p> <b>Methods</b> Data on intake and EN practices were collected on a daily basis and compared against predefined targets and dietary reference values in a paediatric intensive care unit. Factors associated with intake and advancement of EN were explored.<p></p> <b>Results</b> Data were collected from 130 patients and 887 nutritional support days (NSDs). Delay to initiate EN was longer in patients from both the General Surgical and congenital heart defect (CHD) Surgical groups [Median (IQR); CHD Surgical group: 20.3 (16.4) vs General Surgical group: 11.4 (53.5) vs Medical group: 6.5 (10.9) hours; p <= 0.001]. Daily fasting time per patient was significantly longer in patients from the General Surgical and CHD Surgical groups than those from the Medical group [% of 24 h, Median (IQR); CHD Surgical group: 24.0 (29.2) vs General Surgical group: 41.7 (66.7) vs Medical group: 9.4 (21.9); p <= 0.001]. A lower proportion of fluids was delivered as EN per patient (45% vs 73%) or per NSD (56% vs 73%) in those from the CHD Surgical group compared with those with medical conditions. Protein and energy requirements were achieved in 38% and 33% of the NSDs. In a substantial proportion of NSDs, minimum micronutrient recommendations were not met particularly in those patients from the CHD Surgical group. A higher delivery of fluid requirements (p < 0.05) and a greater proportion of these delivered as EN (p < 0.001) were associated with median energy intake during stay and delay of EN advancement. Fasting (31%), fluid restriction (39%) for clinical reasons, procedures requiring feed cessation and establishing EN (22%) were the most common reasons why target energy requirements were not met.<p></p> <b>Conclusions</b> Provision of optimal EN support remains challenging and varies during hospitalisation and among patients. Delivery of EN should be prioritized over other "non-nutritional" fluids whenever this is possible.<p></p&gt

Do protein–protein interaction databases identify moonlighting proteins?

One of the most striking results of the human (and mammalian) genomes is the low number of protein-coding genes. To-date, the main molecular mechanism to increase the number of different protein isoforms and functions is alternative splicing. However, a less-known way to increase the number of protein functions is the existence of multifunctional, multitask, or ‘‘moonlighting’’, proteins. By and large, moonlighting proteins are experimentally disclosed by serendipity. Proteomics is becoming one of the very active areas of biomedical research, which permits researchers to identify previously unseen connections among proteins and pathways. In principle, protein–protein interaction (PPI) databases should contain information on moonlighting proteins and could provide suggestions to further analysis in order to prove the multifunctionality. As far as we know, nobody has verified whether PPI databases actually disclose moonlighting proteins. In the present work we check whether well-established moonlighting proteins present in PPI databases connect with their known partners and, therefore, a careful inspection of these databases could help to suggest their different functions. The results of our research suggest that PPI databases could be a valuable tool to suggest multifunctionality

The relationship between physical activity, sleep duration and depressive symptoms in older adults: The English Longitudinal Study of Ageing (ELSA)

Research to date suggests that physical activity (PA) is associated with distinct aspects of sleep, but studies have predominantly focused on sleep quality, been carried out in younger adults, and have not accounted for many covariates. Of particular interest is also the reported relationship between physical activity and depression in older adults and as such, their associations with sleep duration. Here we examine the cross-sectional relation between physical activity and sleep duration in a community-dwelling sample of 5265 older adults from the English Longitudinal Study of Ageing. We analysed the data using multiple regression, with physical activity as a categorical exposure and sleep duration a continuous outcome, as well as testing the interaction between physical activity and depressive symptoms, which was significant (p  0.05). Our findings suggest that a potentially effective way of improving sleep in older adults with depressive symptoms is via physical activity interventions

Single-epoch VLBI imaging study of bright active galactic nuclei at 2 and 8 GHz

We investigate statistical and individual astrophysical properties of active galactic nuclei (AGNs), such as parsec-scale flux density, core dominance, angular and linear sizes, maximum observed brightness temperatures of VLBI core components, spectral index distributions for core and jet components, and evolution of brightness temperature along the jets. Furthermore, we statistically compare core flux densities and brightness temperature as well as jet spectral indices of gamma-ray bright and weak sources. We used 19 very long baseline interferometry (VLBI) observing sessions carried out simultaneously at 2.3 and 8.6 GHz with the participation of 10 Very Long Baseline Array (VLBA) stations and up to 10 additional geodetic telescopes. The observations span the period 1998-2003. We present here single-epoch results from high-resolution radio observations of 370 AGNs. Our VLBI images at 2.3 and 8.6 GHz as well as Gaussian models are presented and analyzed. At least one-fourth of the cores are completely unresolved on the longest baselines of the global VLBI observations. The VLBI core components are partially opaque with the median value of spectral index of alpha_core=0.3, while the jet features are usually optically thin alpha_jet=-0.7. The spectral index typically decreases along the jet ridge line owing to the spectral aging, with a median value of -0.05 mas^-1. Brightness temperatures are found to be affected by Doppler boosting and reaching up to \sim10^13 K with a median of \sim2.5x10^11 K at both frequencies. The brightness temperature gradients along the jets typically follow a power law T_b\simr^-2.2 at both frequencies. 147 sources (40%) positionally associated with gamma-ray detections from the Fermi LAT Second Source Catalog have higher core flux densities and brightness temperatures, and are characterized by the less steep radio spectrum of the optically thin jet emission.Comment: 15 pages, 21 figures, accepted by A&A on May 22, 2012, machine readable tables are available from the source of the pape

A late Pleistocene–Holocene noble gas paleotemperature record in southern Michigan

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95678/1/grl19236.pd