A Novel Floating High-Voltage Level Shifter with Pre-Storage Technique

This paper proposes a novel floating high-voltage level shifter (FHV-LS) with the pre-storage technique for high speed and low deviation in propagation delay. With this technology, the transmission paths from input to output are optimized, and thus the propagation delay of the proposed FHV-LS is reduced to as low as the sub-nanosecond scale. To further reduce the propagation delay, a pull-up network with regulated strength is introduced to reduce the fall time, which is a crucial part of the propagation delay. In addition, a pseudosymmetrical input pair is used to improve the symmetry of FHV-LS structurally to balance between the rising and falling propagation delays. Moreover, a start-up circuit is developed to initialize the output state of FHV-LS during the VDDH power up. The proposed FHV-LS is implemented using 0.3-µm HVCMOS technology. Post-layout simulation shows that the propagation delays and energy per transition of the proposed FHV-LS are 384 ps and 77.7 pJ @VH = 5 V, respectively. Finally, the 500-points Monte Carlo are performed to verify the performance and the stability

Nutrients mediate intestinal bacteria-mucosal immune crosstalk

The intestine is the shared site of nutrient digestion, microbiota colonization and immune cell location and this geographic proximity contributes to a large extent to their interaction. The onset and development of a great many diseases, such as inflammatory bowel disease and metabolic syndrome, will be caused due to the imbalance of body immune. As competent assistants, the intestinal bacteria are also critical in disease prevention and control. Moreover, the gut commensal bacteria are essential for development and normal operation of immune system and the pathogens are also closely bound up with physiological disorders and diseases mediated by immune imbalance. Understanding how our diet and nutrient affect bacterial composition and dynamic function, and the innate and adaptive status of our immune system, represents not only a research need but also an opportunity or challenge to improve health. Herein, this review focuses on the recent discoveries about intestinal bacteria-immune crosstalk and nutritional regulation on their interplay, with an aim to provide novel insights that can aid in understanding their interactions.Peer reviewedAnimal Scienc

Effect of manganese on the microstructure of Mg–3Al alloy

The effect of manganese on the microstructure of Mg–3Al alloy, especially the nucleation efficiency of Al–Mn particles on primary Mg, has been investigated in this paper. Mg–0.72Mn was used to fabricate Mg–3Al–xMn (x = 0, 0.1, 0.2, 0.3, 0.4 and 0.5) alloys, and the grain sizes of these alloys fluctuate at 390 μm indicating addition of manganese does not evidently influence the grain size of Mg–3Al alloy. Through XRD, FESEM and TEM detection, it is found that Al0.89Mn1.11 compound is the dominant Al–Mn phase in Mg–3Al–0.3Mn, Mg–3Al–0.4Mn and Mg–3Al–0.5Mn, and distributes in primary Mg matrix and interdendritic regions with an angular blocky morphology. The number of Al0.89Mn1.11 increases gradually with increasing manganese content while the grain sizes of primary Mg are nearly the same in Mg–3Al, Mg–3Al–0.3Mn, Mg–3Al–0.4Mn and Mg–3Al–0.5Mn, indicating Al0.89Mn1.11 has low nucleation efficiency on primary Mg

Discussion on early warning method of coal and gas outburst

Definition of early warning of coal and gas outburst was given, and difference between the early warning and forecasting was clearly pointed out. The early warning of coal and gas outburst was classified from angle of space, time and index system, and features of the early warning were put forward according to specific characteristics of coal and gas outburst disaster. System structure and implementation of the early warning were analyzed guided by system theory and accident theory. Steps of the early warning were described from five aspects of detection of risk source, warning sign identification, analysis of warning situation, alert release and early warning response. Method of effect evaluation of the early warning was put forward by using three indicators of initial warning accuracy, false negative rate and false alarm rate. The field application results show that the average accuracy rate of state warning is 89.1%, the average accuracy rate of trend warning is 92.5%, and the false negative rate is 0

A Broadband Beamformer Suitable for UUV to Detect the Tones Radiated from Marine Vessels

In this paper, the issue that the underwater unmanned vehicle (UUV) with a sonar array achieves the passive detection of vessel targets by detecting the tones radiated from the targets is considered. The multi-beam low-frequency analysis and recording method is widely applied in a manned sonar system. The sonar operator provides an auxiliary decision to extract the target tones from the multiple beams output. However, the complexity of the multi-dimensional information fusion makes it difficult to apply the multi-beam processing in the unmanned sonar system. Aiming at this problem, we introduce the self-adjusting characteristics of adaptive line enhancer to a time domain broadband beamformer and then propose a self-steering broadband beamformer. The proposed beamformer can adaptively steer the main beam to the direction-of-arrival (DOA) of the tonal target. There is no need to pre-form the multiple beams. The complexity of the UUV-based tone detection is reduced. Theoretical derivation and simulation experiments verify that the main beam of the proposed beamformer can track the DOA of tonal target which is rapidly changing. Meanwhile, the tonal interferences as well as the wide-band noise are well suppressed

Branched Chain Amino Acids: Beyond Nutrition Metabolism

Branched chain amino acids (BCAAs), including leucine (Leu), isoleucine (Ile), and valine (Val), play critical roles in the regulation of energy homeostasis, nutrition metabolism, gut health, immunity and disease in humans and animals. As the most abundant of essential amino acids (EAAs), BCAAs are not only the substrates for synthesis of nitrogenous compounds, they also serve as signaling molecules regulating metabolism of glucose, lipid, and protein synthesis, intestinal health, and immunity via special signaling network, especially phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signal pathway. Current evidence supports BCAAs and their derivatives as the potential biomarkers of diseases such as insulin resistance (IR), type 2 diabetes mellitus (T2DM), cancer, and cardiovascular diseases (CVDs). These diseases are closely associated with catabolism and balance of BCAAs. Hence, optimizing dietary BCAA levels should have a positive effect on the parameters associated with health and diseases. This review focuses on recent findings of BCAAs in metabolic pathways and regulation, and underlying the relationship of BCAAs to related disease processes

Optimization of Sparse Planar Arrays with Minimum Spacing and Geographic Constraints in Smart Ocean Applications

Sparse arrays can fix array aperture with a reduced number of elements to maintain resolution while reducing cost. However, grating lobe suppression, high peak side-lobe level reduction (PSLL), and constraints on the location of the array elements in the practical deployment of arrays are challenging problems. Based on simulated annealing, the element locations of a sparse planar array in smart ocean applications with minimum spacing and geographic constraints are optimized in this paper by minimizing the sum of PSLL. The robustness of the deployment-optimized spare planar array with mis-calibration is further considered. Numerical simulations show the effectiveness of the proposed solution

Research on an Enhanced Detuned-Loading Effect in Integrated Two-Section DFB Lasers with High Modulation Bandwidths

A novel high-speed directly modulated two-section distributed-feedback (TS-DFB) semiconductor laser based on the detuned-loading effect is proposed and simulated. A grating structure is designed by the reconstruction-equivalent-chirp (REC) technique. A π phase shift is introduced into the reflection grating, which can provide a narrow-band reflection region with a sharp falling slope on both sides of the reflection spectrum, thus enhancing the detuned-loading effect. Owing to its unique dual-falling-edges structure, the bandwidth can be improved even when the lasing wavelength shifts beyond the left falling edge due to a thermal effect in the actual test, in which condition the detuned-loading effect can be used twice, which greatly improves the yield. The modulation bandwidth is increased from 17.5 GHz for a single DFB laser to around 24 GHz when the lasing wavelength is located on the left falling edge of the TS-DFB laser based on the detuned-loading effect, and it can be increased to 22 GHz for the right side. An eight-channel laser array with precise wavelength spacing is investigated, with a side-mode suppression ratio (SMSR) >36 dB. In addition, TS-DFB lasers with uniform reflection gratings are studied, and simulated results show that the modulation characteristic is far inferior to the laser with a phase-shifted grating reflector

USP14 as a novel prognostic marker promotes cisplatin resistance via Akt/ERK signaling pathways in gastric cancer

Abstract Gastric cancer (GC) ranks the third leading cause of global cancer mortality. Despite recent progress in surgery combined with chemotherapy, the outcomes of GC patients have barely improved. Therefore, better understanding of the molecular mechanisms involved in chemoresistance of GC may help develop novel strategies to treat this deadly disease. Previous evidence has shown aberrant expressions of USP14 in multiple malignancies, suggesting an important role of USP14 in tumorigenesis. However, its role in modulating chemoresistance in GC still remains elusive. In this study, we observed that USP14 levels were significantly increased in GC tissues compared to the paired normal tissues. Multivariate analysis demonstrated that USP14 level was an independent prognostic factor for DFS in GC patients. Silencing of USP14 promoted proteasomal degradation of p‐ERK (T202/Y204) and p‐Akt (T308/S473), thus inactivating Akt and ERK signaling pathways. Interestingly, silencing of USP14 alone was not sufficient to cause overt effects on cell growth, proliferation, and apoptosis, while resulting in significant apoptosis in the presence of cisplatin in GC cells. Thus, knockdown of USP14 sensitized GC cells to cisplatin by triggering cisplatin‐induced apoptosis via impeding Akt and ERK signaling pathways. These results revealed a novel role of USP14 in modulating chemosensitivity of GC cells, suggesting USP14 may serve as not only a prognostic marker, but also a potential therapeutic target for GC patients