The Symmetry behind Extended Flavour Democracy and Large Leptonic Mixing

We show that there is a minimal discrete symmetry which leads to the extended flavour democracy scenario constraining the Dirac neutrino, the charged lepton and the Majorana neutrino mass term ($M_R$) to be all proportional to the democratic matrix, with all elements equal. In particular, this discreet symmetry forbids other large contributions to $M_R$, such as a term proportional to the unit matrix, which would normally be allowed by a $S_{3L}\times S_{3R}$ permutation symmetry. This feature is crucial in order to obtain large leptonic mixing, without violating 't Hooft's, naturalness principle.Comment: 11 pages, LaTe

Phenomenological Relation between Distribution and Fragmentation Functions

We study the relation between the quark distribution function q(x) and the fragmentation function D_q(z) based on a general form D_q(x) = C(z)z^{alpha}q(z) for valence and sea quarks. By adopting two known parametrizations of quark distributions for the proton, we find three simple options for the fragmentation functions that can provide a good description of the available experimental data on proton production in e^+ e^- inelastic annihilation. These three options support the revised Gribov-Lipatov relation D_q(z) = z q(z) at z --> 1, as an approximate relation for the connection between distribution and fragmentation functions. The three options differ in the sea contributions and lead to distinct predictions for antiproton production in the reaction p+p --> p-bar+X, thus they are distinguishable in future experiments at RHIC-BNL.Comment: 13 pages, 5 eps figure

Finite Grand Unified Theories and the Quark Mixing Matrix

In N = 1 super Yang-Mills theories, under certain conditions satisfied by the spectrum and the Yukawa couplings, the beta functions will vanish to all orders in perturbation theory. We address the generation of realistic quark mixing angles and masses in such finite Grand Unified Theories. Working in the context of finite SUSY SU(5), we present several examples with realistic quark mixing matrices. Non-Abelian discrete symmetries are found to be important in satisfying the conditions for finiteness. Our realistic examples are based on permutation symmetries and the tetrahedral symmetry $A_4$. These examples enable us to address questions such as the decay rate of the proton in finite GUTs.Comment: 16 pages, LaTeX, typos correcte

Neutrino masses and mixing with seesaw mechanism and universal breaking of extended democracy

In the framework of a minimal extension of the SM, where the only additional fields are three right-handed neutrinos, we suggest that the charged lepton, the Dirac neutrino and the right-handed Majorana neutrino mass matrices are all, to leading approximation, proportional to the democratic matrix. With the further assumption that the breaking of this extended democracy is universal for all leptonic mass matrices, a large mixing in the 2-3 sector can be obtained and is linked to the seesaw mechanism, together with the existence of a strong hierarchy in the masses of right-handed neutrinos. The structure of the resulting effective mass matrix of light neutrinos is stable against the RGE evolution, and a good fit to all solar and atmospheric neutrino data is obtained.Comment: LaTeX, 17 pages, 2 eps figures. A section on RGE evolution and a few references added; minor typos correcte

The Problem of Large Leptonic Mixing

Unlike in the quark sector where simple $S_3$ permutation symmetries can generate the general features of quark masses and mixings, we find it impossible (under conditions of hierarchy for the charged leptons and without considering the see-saw mechanism or a more elaborate extension of the SM) to guarantee large leptonic mixing angles with any general symmetry or transformation of only known particles. If such symmetries exist, they must be realized in more extended scenarios.Comment: RevTeX, 4 pages, no figure

Association of dialysis facility-level hemoglobin measurement and erythropoiesis-stimulating agent dose adjustment frequencies with dialysis facility-level hemoglobin variation: a retrospective analysis

<p>Abstract</p> <p>Background</p> <p>A key goal of anemia management in dialysis patients is to maintain patients' hemoglobin (Hb) levels consistently within a target range. Our aim in this study was to assess the association of facility-level practice patterns representing Hb measurement and erythropoiesis-stimulating agent (ESA) dose adjustment frequencies with facility-level Hb variation.</p> <p>Methods</p> <p>This was a retrospective observational database analysis of patients in dialysis facilities affiliated with large dialysis organizations as of July 01, 2006, covering a follow-up period from July 01, 2006 to June 30, 2009. A total of 2,763 facilities representing 436,442 unique patients were included. The predictors evaluated were facility-level Hb measurement and ESA dose adjustment frequencies, and the outcome measured was facility-level Hb variation.</p> <p>Results</p> <p>First to 99th percentile ranges for facility-level Hb measurement and ESA dose adjustment frequencies were approximately once per month to once per week and approximately once per 3 months to once per 3 weeks, respectively. Facility-level Hb measurement and ESA dose adjustment frequencies were inversely associated with Hb variation. Modeling results suggested that a more frequent Hb measurement (once per week rather than once per month) was associated with approximately 7% to 9% and 6% to 8% gains in the proportion of patients with Hb levels within a ±1 and ±2 g/dL range around the mean, respectively. Similarly, more frequent ESA dose adjustment (once per 2 weeks rather than once per 3 months) was associated with approximately 6% to 9% and 5% to 7% gains in the proportion of patients in these respective Hb ranges.</p> <p>Conclusions</p> <p>Frequent Hb measurements and timely ESA dose adjustments in dialysis patients are associated with lower facility-level Hb variation and an increase in proportion of patients within ±1 and ±2 g/dL ranges around the facility-level Hb mean.</p

Invariants, Alignment and the Pattern of Fermion Masses and Mixing

We show that the main features of the pattern of fermion masses and mixing can be expressed in terms of simple relations among weak-basis invariants. In the quark sector, we identify the weak-basis invariants which signal the observed alignment of the up and down quark mass matrices in flavour space. In the lepton sector, we indicate how a set of conditions on weak-basis invariants can lead to an approximate tribimaximal lepton mixing matrix. We also show the usefulness of these invariants in the study of specific ans\"atze for the flavour structure of fermion mass matrices.Comment: 16 pages, 1 figur

Mass and Flavor Mixing Schemes of Quarks and Leptons

We give an overview of recent progress in the study of fermion mass and flavor mixing phenomena. The hints exhibited by the quark and lepton mass spectra towards possible underlying flavor symmetries, from which realistic models of mass generation could be built, are emphasized. A variety of schemes of quark mass matrices at low and superhigh energy scales are described, and their consequences on flavor mixing and CP violation are discussed. Instructive patterns of lepton mass matrices, which can naturally lead to large flavor mixing angles, are explored to interpret current data on atmospheric and solar neutrino oscillations. We expect that B-meson factories and long-baseline neutrino experiments will soon shed more light on the dynamics of fermion masses, flavor mixing and CP violation.Comment: LaTex 81 pages. Minor changes made, typing errors corrected, and references added. Prog. Part. Nucl. Phys. (in printing

Finite Theories and the SUSY Flavor Problem

We study a finite SU(5) grand unified model based on the non-Abelian discrete symmetry A_4. This model leads to the democratic structure of the mass matrices for the quarks and leptons. In the soft supersymmetry breaking sector, the scalar trilinear couplings are aligned and the soft scalar masses are degenerate, thus solving the SUSY flavor problem.Comment: 17 pages, LaTeX, 1 figur

Optimal and continuous anaemia control in a cohort of dialysis patients in Switzerland

BACKGROUND: Guidelines for the management of anaemia in patients with chronic kidney disease (CKD) recommend a minimal haemoglobin (Hb) target of 11 g/dL. Recent surveys indicate that this requirement is not met in many patients in Europe. In most studies, Hb is only assessed over a short-term period. The aim of this study was to examine the control of anaemia over a continuous long-term period in Switzerland. METHODS: A prospective multi-centre observational study was conducted in dialysed patients treated with recombinant human epoetin (EPO) beta, over a one-year follow-up period, with monthly assessments of anaemia parameters. RESULTS: Three hundred and fifty patients from 27 centres, representing 14% of the dialysis population in Switzerland, were included. Mean Hb was 11.9 +/- 1.0 g/dL, and remained stable over time. Eighty-five % of the patients achieved mean Hb &amp;gt;or= 11 g/dL. Mean EPO dose was 155 +/- 118 IU/kg/week, being delivered mostly by subcutaneous route (64-71%). Mean serum ferritin and transferrin saturation were 435 +/- 253 microg/L and 30 +/- 11%, respectively. At month 12, adequate iron stores were found in 72.5% of patients, whereas absolute and functional iron deficiencies were observed in only 5.1% and 17.8%, respectively. Multivariate analysis showed that diabetes unexpectedly influenced Hb towards higher levels (12.1 +/- 0.9 g/dL; p = 0.02). One year survival was significantly higher in patients with Hb &amp;gt;or= 11 g/dL than in those with Hb &amp;lt;11 g/dL (19.7% vs 7.3%, p = 0.006). CONCLUSION: In comparison to European studies of reference, this survey shows a remarkable and continuous control of anaemia in Swiss dialysis centres. These results were reached through moderately high EPO doses, mostly given subcutaneously, and careful iron therapy management