Paradox as invitation to act in problematic change situations

It has been argued that organizational life typically contains paradoxical situations such as efforts to manage change which nonetheless seem to reinforce inertia. Four logical options for coping with paradox have been explicated, three of which seek resolution and one of which ‘keeps the paradox open’. The purpose of this article is to explore the potential for managerial action where the paradox is held open through the use of theory on ‘serious playfulness’. Our argument is that paradoxes, as intrinsic features in organizational life, cannot always be resolved through cognitive processes. What may be possible, however, is that such paradoxes are transformed, or ‘moved on’ through action and as a result the overall change effort need not be stalled by the existence of embedded paradoxes

Thermal compression of atomic hydrogen on helium surface

We describe experiments with spin-polarized atomic hydrogen gas adsorbed on liquid $^{4}$He surface. The surface gas density is increased locally by thermal compression up to $5.5\times10^{12}$ cm$^{-2}$ at 110 mK. This corresponds to the onset of quantum degeneracy with the thermal de-Broglie wavelength being 1.5 times larger than the mean interatomic spacing. The atoms were detected directly with a 129 GHz electron-spin resonance spectrometer probing both the surface and the bulk gas. This, and the simultaneous measurement of the recombination power, allowed us to make accurate studies of the adsorption isotherm and the heat removal from the adsorbed hydrogen gas. From the data, we estimate the thermal contact between 2D hydrogen gas and phonons of the helium film. We analyze the limitations of the thermal compression method and the possibility to reach the superfluid transition in 2D hydrogen gas.Comment: 20 pages, 11 figure

[Accepted Manuscript] Presymptomatic atrophy in autosomal dominant Alzheimer's disease: A serial MRI study.

Identifying at what point atrophy rates first change in Alzheimer's disease is important for informing design of presymptomatic trials. Serial T1-weighed magnetic resonance imaging scans of 94 participants (28 noncarriers, 66 carriers) from the Dominantly Inherited Alzheimer Network were used to measure brain, ventricular, and hippocampal atrophy rates. For each structure, nonlinear mixed-effects models estimated the change-points when atrophy rates deviate from normal and the rates of change before and after this point. Atrophy increased after the change-point, which occurred 1-1.5 years (assuming a single step change in atrophy rate) or 3-8 years (assuming gradual acceleration of atrophy) before expected symptom onset. At expected symptom onset, estimated atrophy rates were at least 3.6 times than those before the change-point. Atrophy rates are pathologically increased up to seven years before "expected onset". During this period, atrophy rates may be useful for inclusion and tracking of disease progression

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus

A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10-20), ER-negative BC (P=1.1 × 10-13), BRCA1-associated BC (P=7.7 × 10-16) and triple negative BC (P-diff=2 × 10-5). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P=2 × 10-3) and ABHD8 (P<2 × 10-3). Chromosome conformation capture identifies interactions between four candidate SNPs and ABHD8, and luciferase assays indicate six risk alleles increased transactivation of the ADHD8 promoter. Targeted deletion of a region containing risk SNP rs56069439 in a putative enhancer induces ANKLE1 downregulation; and mRNA stability assays indicate functional effects for an ANKLE1 3′-UTR SNP. Altogether, these data suggest that multiple SNPs at 19p13 regulate ABHD8 and perhaps ANKLE1 expression, and indicate common mechanisms underlying breast and ovarian cancer risk

Numerical solution of an electropaint problem

SIGLEAvailable from British Library Document Supply Centre-DSC:DXN007054 / BLDSC - British Library Document Supply CentreGBUnited Kingdo

THE UK FREE ELECTRON LASER

Un projet de laser à électrons libres a maintenant été formellement approuvé par le Royaume-Uni. Il est basé sur l'accélérateur de haute puissance linéaire du Laboratoire Kelvin à Kilbride Est, Ecosse. Les paramètres caractéristiques du système, centrés sur une radiation de sortie de 10,6 µm, sont présentés en détail. Le programme expérimental proposé est résumé brièvement et on mentionne les possibilités de recherche appliquée.A UK free electron laser project has now been formally approved, based on the high power linear accelerator of the Kelvin Laboratory at East Kilbride, Scotland. Detailed design parameters of the system, centred on 10.6 µm output radiation, are presented. The proposed experimental programme is briefly summarised and possible research applications are mentioned

FEL options for the proposed UK fourth generation light source (4GLS)

4GLS is a novel low-energy light source proposed as a complementary facility to the DIAMOND X-ray project for the UK, and could probably replace the present SRS at Daresbury in about 6 years time. This facility will use a combination of three separate FELs, undulators and bending magnets to provide a unique source of high-brightness continuous and pulsed radiation from the IR to XUV (~100 eV). Here, we give a brief description of the proposed FELs in the IR and VUV followed by a pre-design parameter study of the more technically challenging XUV high-gain FEL. The electron beam source for this FEL is a 600MeV superconducting energy recovery linac with peak currents of a few kA, normalised rms emittance ~3 pi mm-mrad and rms energy spread ∼5×10-4. Computer simulations using the 3-D FEL code GENESIS 1.3 are used to investigate a feasible undulator and beam focussing scheme, allowing estimates for achievable radiation power and saturation length to be made

DEVELOPMENT OF AN UNDULATOR MAGNET FOR THE DARESBURY SYNCHROTRON RADIATION SOURCE

On décrit le projet d'un onduleur de 1 m de longueur constitué de blocs de matériau terre rare-cobalt ainsi que les méthodes utilisées pour calculer la distribution de champ à 3 dimensions ainsi que les forces magnétiques. On expose une méthode de test des blocs de manière à déduire l'information concernant les erreurs sur l'aimantation. Des résultats sont présentés et évalués en termes d'effets sur la trajectoire du faisceau d'électrons.The design of a 1 m long undulator composed of rare earth cobalt blocks and the methods used to calculate 3-dimensional field distributions and magnetic forces are described. A scheme for testing the blocks to derive information on magnetisation errors has been developed. Results are presented and evaluated in terms of the effect on the electron beam trajectory