A CONCEPTUAL REVIEW ON TAILA MURCHANA

Taila kalpana has widely used dosage form described in Ayurvedic formulations for both external and internal use. Taila murchana is the first step of Taila preparation. Murchana has been adopted for enhancing the potency of oil and to remove the bad odour and Amadosa. In classics Tailas like Tilataila (sesame), Eranda (Castor) taila, Katu (Mustard) Taila needs Murchanaas preliminary process of Taila paaka. It has been mentioned in detail for the first time in Bhaishajya Ratnavali. Fat/Water soluble active principles of drugs are extracted into medicated oil in this method. Taila with Murchana are having more therapeutic potency and shelf life than crude Taila. The process of Murchana has high significance in today's scenario of globalization and the urge for better therapeutic efficacy. Hence the process of Murchana must be strictly included as the prerequisites of any medicated oil preparations. In this article an attempt has been done to review concepts regarding Taila murchana in literature of Ayurvedic pharmaceutics

Risk classification at diagnosis predicts post-HCT outcomes in intermediate-, adverse-risk, and KMT2A-rearranged AML

Little is known about whether risk classification at diagnosis predicts post-hematopoietic cell transplantation (HCT) outcomes in patients with acute myeloid leukemia (AML). We evaluated 8709 patients with AML from the CIBMTR database, and after selection and manual curation of the cytogenetics data, 3779 patients in first complete remission were included in the final analysis: 2384 with intermediate-risk, 969 with adverse-risk, and 426 with KMT2A-rearranged disease. An adjusted multivariable analysis detected an increased risk of relapse for patients with KMT2A-rearranged or adverse-risk AML as compared to those with intermediate-risk disease (hazards ratio [HR], 1.27; P 5.01; HR, 1.71; P,.001, respectively). Leukemia-free survival was similar for patients with KMT2A rearrangement or adverse risk (HR, 1.26; P 5.002, and HR, 1.47; P,.001), as was overall survival (HR, 1.32; P,.001, and HR, 1.45; P,.001). No differences in outcome were detected when patients were stratified by KMT2A fusion partner. This study is the largest conducted to date on post-HCT outcomes in AML, with manually curated cytogenetics used for risk stratification. Our work demonstrates that risk classification at diagnosis remains predictive of post-HCT outcomes in AML. It also highlights the critical need to develop novel treatment strategies for patients with KMT2A-rearranged and adverse-risk disease

State of the world’s plants and fungi 2020

Kew’s State of the World’s Plants and Fungi project provides assessments of our current knowledge of the diversity of plants and fungi on Earth, the global threats that they face, and the policies to safeguard them. Produced in conjunction with an international scientific symposium, Kew’s State of the World’s Plants and Fungi sets an important international standard from which we can annually track trends in the global status of plant and fungal diversity

The column-sufficiency and row-sufficiency of the linear transformation on Hilbert spaces

Linear complementarity problem, Jordan product, Lorentz cone, Column-sufficiency, Row-sufficiency,

PGPR in Groundnut: Opportunities and Challenges

Groundnut (Arachis hypogaea L.) is an important food legume in Asian Countries earning a lot of revenue, In the semi-arid tropics, the production levels of groundnut are hampered majorly by foliar and soilborne diseases incited by fungal pathogens. Present management of these groudnut diseases using chemical fungicides has environment related concerns

Heat transfer in a side heated trapezoidal cavity with openings

A control volume based numerical study has been carried out on trapezoidal cavity which has formed by inclined left heated wall and insulated bottom horizontal walls. The calculations are performed for Rayleigh numbers varying from 103 to 107 and orientation of heated wall is ϕ=60° and 120°. The results are compared for cases without opening and with different openings of the vertical wall as functions of isotherms, streamfunctions, local and average heat transfer rates. The overall Nusselt number increases with increase of Rayleigh number, but decreases with increase in angle of orientation. The transition region between conduction to convection is existing almost at Ra = 5 × 103. It has been observed that the case having vents at extreme ends exhibits highest heat transfer compared to other cases. The heat transfer is better for the orientation angle of 60°. As compare to uniformly cooled wall, the heat transfer is enhanced by 23%, 39%, 56% and 74% at Ra = 104, 105, 106 and 107 respectively. The power law correlations have been developed between average Nusselt numbers and Rayleigh numbers. Keywords: Natural convection, Inclined trapezoidal cavity, Heat flux, Energy and building, Partially open cavit