ANALISI DELLA MORTALITA' NELLE PROVINCE PUGLIESI DAL 1949 AL 2008

Dalla fine degli anni '60, la Puglia è teaaatro di una vasta industrializzazione. Lo studio, storico-epidemiologico mira a valutare l'andamento della mortalità generale e dei tumori respiratori in quinquenni che coprono la finestra temporale 1949-2008

OMEGA-3 FATTY ACIDS, INFLAMMATION AND ANGIOGENESIS: NUTRIGENOMIC EFFECTS AS AN EXPLANATION FOR ANTI-ATHEROGENIC AND ANTI-INFLAMMATORY EFFECTS OF FISH AND FISH OILS

Atherosclerosis is a dynamic process with inflammatory aspects playing a considerable pathogenetic role. In this process, the vascular endothelium is the key regulator of vascular function, promoting the maintenance of vascular homeostasis or the progression towards vascular disease. In the past 30 years, the dietary intake of omega–3 (n–3) polyunsaturated fatty acids – mainly derived from fish – has emerged as an important way to modify cardiovascular risk through beneficial effects on all stages of atherosclerosis. This review specifically focuses on the modulating effects of n–3 fatty acids on molecular events involved in early and late atherogenesis, including effects on endothelial expression of adhesion molecules, as well as pro-inflammatory and proangiogenic enzymes. By accumulating in endothelial membrane phospholipids, omega–3 fatty acids have been shown to decrease the transcriptional activation of several genes through a decreased activation of the nuclear factor- _ B system of transcription factors. This occurs secondary to decreased generation of intracellular reactive oxygen species. Omega–3 fatty acids have recently emerged as an example of nutrients able to modulate the expression of genes involved in inflammation and atherosclerosis. Their ability to influence such processes is therefore a good example of nutrigenomics. This review summarizes the evidence to this regard. Since a description of the molecular events underlying endothelial changes in atherosclerosis is important for an understanding of the mode of action of these nutrients, a short review of current concepts of inflammation and atherosclerosis gives the background to place their genomic effect in context

Heterogeneous distribution of dopamine D2-like receptors in the rat entorhinal cortex.

J. Neural Trasm., 103/10, XLII, 1996. Rome October 28-30 199

Utilization of microsatellite instability (MSI) as genomic markers in endometrial cancer: Scientific evidences

Endometrial Cancer is the more frequent tumor in Occidental ands, with 142,000 new cases for year and 42,000 deaths; this cancer typically trikes women between 55 and 65 years and it is on the fourth place in female tumors. Edogen predisposing conditions to endometrial cancer development are: late menopause, early menarche, and hyperestrogenism, while hormone replacement theraphy, obesity, alcoholm diabetes, diet rich of animal fats and chronic liver disease represent exogenous factors. This tumor can arise even as hereditary predisposition, as in Lynch Syndrome or HNPCC (Hereditary NonPolyposis Colorectal Cancer), since the genetic modifications induced by "mismatch repair" (MMR) genes lead to a tumoral development susceptibility, not only in colon. The phenotypical consequence of these genetic modifications is the microsatellite instability (MSI) and in loss of heterozygosity (LOH), whom create the RER (replication errors in repeats) positive phenotype, who express the incapability to repair short nucleotide insertions or deletions, generates by an uncorrected DNA replication; by these genetic modifications, new allelic variants arise in endometrial tissue, confirming te elevate degree of genetic disorder. Recent studies showed that the MSI and LOH in endomerial cells can be associated to the loss of cellular control expression and to degeneration of cellular growth phenomenon. It exist the possibility to utilize these new genetic markers in the endometrial mucosa, to study by genomic these tissue and to detect the possible neoplastic transformation

An autoradiography comparative study with [125I]-NCQ 298 and [125I]-epidepride on the rat caudate-putamen dopamine receptors.

Trends in Neurosciences September 1997, Vol. 20 No 9, supplement ISSN 0166-223