A magnetic resonance imaging surface coil transceiver employing a metasurface for 1.5T applications

A capacitive impedance metasurface combined with a transceiver coil to improve the radio frequency magnetic field for 1.5T magnetic resonance imaging applications is presented. The novel transceiver provides localized enhancement in magnetic flux density when compared to a transceiver coil alone by incorporating an electrically small metasurface using an interdigital capacitance approach. Full field simulations employing the metasurface show a significant improvement in magnetic flux density inside a homogeneous dielectric phantom, which is also shown to perform well for a range of depths into the phantom. The concept was experimentally demonstrated through vector network analyzer measurements and images have been taken using a 1.5T MRI scanner. The results show there is a 216% improvement in transmission efficiency, a 133% improvement in receiver signal-to-noise-ratio (SNR), and a 415% improvement in transceiver SNR for a particular transmission power when compared against a surface coil positioned at the same distance from the phantom, where these improvements are the maximum observed during experiments

Low-profile independently- and concurrently-tunable quad-band antenna for single chain sub-6GHz 5G new radio applications

This paper presents a quad-band frequency agile antenna, with independent and concurrent frequency tunability in each band, for a tunable, concurrent, quad-band single chain radio receiver for 5G New Radio (NR). More specifically, the antenna comprises of four planar slots etched in a ground plane and fed through a single microstrip feedline, without any impedance matching network. The structure is optimized to maximize isolation between the individual slots and their respective resonant frequencies. Furthermore, a novel high order harmonic suppression method is demonstrated, which controls the current distribution via creating a fictitious short circuit in the slot antenna-enabling the antenna to achieve a much wider tuning range. Numerical simulations are verified using experimental implementation and measurements, with good agreement observed. The four slots resonate around the 830 MHz, 1.8 GHz, 2.4 GHz and 3.4 GHz frequency bands, which are independently tuned (using a varactor diode in each slot) to achieve tuning ranges of approximately 64%, 66%, 27% and 33%, respectively. More importantly, the contiguous four bands covers a total frequency tuning from 0.6 to 3.6 GHz i.e. a tuning range of approximately 143%. Finally, far-field measurements are performed and the antenna is evaluated in over-the-air testbed (quad-band radio receiver), which measures the Error Vector Magnitude performance for the individual channels. Good performance is observed, confirming acceptable isolation performance between the four bands. The data reported in this paper is available, from ORDA-The University of Sheffield Research Data Catalogue and Repository, at https://doi.org/10.15131/shef.data.11219000.v1

Gravitons and Lightcone Fluctuations

Gravitons in a squeezed vacuum state, the natural result of quantum creation in the early universe or by black holes, will introduce metric fluctuations. These metric fluctuations will introduce fluctuations of the lightcone. It is shown that when the various two-point functions of a quantized field are averaged over the metric fluctuations, the lightcone singularity disappears for distinct points. The metric averaged functions remain singular in the limit of coincident points. The metric averaged retarded Green's function for a massless field becomes a Gaussian which is nonzero both inside and outside of the classical lightcone. This implies some photons propagate faster than the classical light speed, whereas others propagate slower. The possible effects of metric fluctuations upon one-loop quantum processes are discussed and illustrated by the calculation of the one-loop electron self-energy.Comment: 18pp, LATEX, TUTP-94-1

Concurrent multiband direct RF sampling receivers

Direct radio frequency (RF) sampling receivers are investigated for use in concurrent multiband reception for mobile broadband (MBB) applications. The recent proliferation of different frequency bands and standards in wireless communications has allowed large increases in mobility and throughput, but the number of receivers in a device is limited by physical space and power consumption. Software Defined Radio (SDR) is increasingly being explored to reduce the number of analog RF components required. This paper examines the use of direct RF digitization, allowing tunable and concurrent reception of multiple bands with a single RF front-end. Full mathematical models of both Nyquist and subband sampling receivers are presented and used to investigate a quadband LTE receiver, which is modeled in Simulink and implemented in a hardware-in-the-loop (HWIL) testbed. Individual bands are simulated to have at worst -95dBm sensitivity for 16-QAM with Nyquist sampling and -83dBm with subband sampling. Desensitization of the receivers due to multiband processing is evaluated theoretically and experimentally, showing a maximum of 3dB degradation, which is within the LTE standard for adjacent band interference

Tri-band single chain radio receiver for concurrent radio

The bandwidth available for improving throughputs to future mobile devices at sub-6 GHz frequencies can be increased through aggregating multiple non-contiguous bands, which may be using the same or different radio access technologies to transmit information. However, with conventional radio technology, a complete radio frequency (RF) chain is required for each band, limiting the possible increase due to space and energy consumption restraints in the mobile station (MS). This paper presents and measures a single RF chain radio for concurrent reception of three non-contiguous bands transmitting 16-QAM LTE signals, using a tunable analogue front-end and software defined radio (SDR) techniques. The receiver sensitivity is degraded by only 6dB under worst-case concurrent reception, compared with reception of a single band. This demonstrates that complex signaling techniques can be received concurrently with a single radio chain while meeting the 3GPP standards, opening the way to compact, efficient, multiband receivers for future standards

Study protocol: a randomised controlled trial on the clinical effects of levothyroxine treatment for subclinical hypothyroidism in people aged 80 years and over

Background: Subclinical hypothyroidism is common in older people and its contribution to health and disease needs to be elucidated further. Observational and clinical trial data on the clinical effects of subclinical hypothyroidism in persons aged 80 years and over is inconclusive, with some studies suggesting harm and some suggesting benefits, translating into equipoise whether levothyroxine therapy provides clinical benefits. This manuscript describes the study protocol for the Institute for Evidence-Based Medicine in Old Age (IEMO) 80-plus thyroid trial to generate the necessary evidence base. Methods: The IEMO 80-plus thyroid trial was explicitly designed as an ancillary experiment to the Thyroid hormone Replacement for Untreated older adults with Subclinical hypothyroidism randomised placebo controlled Trial (TRUST) with a near identical protocol and shared research infrastructure. Outcomes will be presented separately for the IEMO and TRUST 80-plus groups, as well as a pre-planned combined analysis of the 145 participants included in the IEMO trial and the 146 participants from the TRUST thyroid trial aged 80 years and over. The IEMO 80-plus thyroid trial is a multi-centre randomised double-blind placebo-controlled parallel group trial of levothyroxine treatment in community-dwelling participants aged 80 years and over with persistent subclinical hypothyroidism (TSH ≥4.6 and ≤ 19.9 mU/L and fT4 within laboratory reference ranges). Participants are randomised to levothyroxine 25 or 50 micrograms daily or matching placebo with dose titrations according to TSH levels, for a minimum follow-up of one and a maximum of three years. Primary study endpoints: hypothyroid physical symptoms and tiredness on the thyroid-related quality of life patient-reported outcome (ThyPRO) at one year. Secondary endpoints: generic quality of life, executive cognitive function, handgrip strength, functional ability, blood pressure, weight, body mass index, and mortality. Adverse events will be recorded with specific interest on cardiovascular endpoints such as atrial fibrillation and heart failure. Discussion: The combined analysis of participants in the IEMO 80-plus thyroid trial with the participants aged over 80 in the TRUST trial will provide the largest experimental evidence base on multimodal effects of levothyroxine treatment in 80-plus persons to date

Massless Minimally Coupled Fields in De Sitter Space: O(4)-Symmetric States Versus De Sitter Invariant Vacuum

The issue of de Sitter invariance for a massless minimally coupled scalar field is revisited. Formally, it is possible to construct a de Sitter invariant state for this case provided that the zero mode of the field is quantized properly. Here we take the point of view that this state is physically acceptable, in the sense that physical observables can be computed and have a reasonable interpretation. In particular, we use this vacuum to derive a new result: that the squared difference between the field at two points along a geodesic observer's space-time path grows linearly with the observer's proper time for a quantum state that does not break de Sitter invariance. Also, we use the Hadamard formalism to compute the renormalized expectation value of the energy momentum tensor, both in the O(4) invariant states introduced by Allen and Follaci, and in the de Sitter invariant vacuum. We find that the vacuum energy density in the O(4) invariant case is larger than in the de Sitter invariant case.Comment: TUTP-92-1, to appear in Phys. Rev.

Different Roles of BDNF in Nucleus Accumbens Core versus Shell during the Incubation of Cue-Induced Cocaine Craving and Its Long-Term Maintenance

Brain-derived neurotrophic factor (BDNF) contributes to diverse types of plasticity, including cocaine addiction. We investigated the role of BDNF in the rat nucleus accumbens (NAc) in the incubation of cocaine craving over 3 months of withdrawal from extended access cocaine self-administration. First, we confirmed by immunoblotting that BDNF levels are elevated after this cocaine regimen on withdrawal day 45 (WD45) and showed that BDNF mRNA levels are not altered. Next, we explored the time course of elevated BDNF expression using immunohistochemistry. Elevation of BDNF in the NAc core was detected on WD45 and further increased on WD90, whereas elevation in shell was not detected until WD90. Surface expression of activated tropomyosin receptor kinase B (TrkB) was also enhanced on WD90. Next, we used viral vectors to attenuate BDNF-TrkB signaling. Virus injection into the NAc core enhanced cue-induced cocaine seeking on WD1 compared with controls, whereas no effect was observed on WD30 or WD90. Attenuating BDNF-TrkB signaling in shell did not affect cocaine seeking on WD1 or WD45 but significantly decreased cocaine seeking on WD90. These results suggest that basal levels of BDNF transmission in the NAc core exert a suppressive effect on cocaine seeking in early withdrawal (WD1), whereas the late elevation of BDNF protein in NAc shell contributes to incubation in late withdrawal (WD90). Finally, BDNF protein levels in the NAc were significantly increased after ampakine treatment, supporting the novel hypothesis that the gradual increase of BDNF levels in NAc accompanying incubation could be caused by increased AMPAR transmission during withdrawal

Spontaneous emission between an unusual pair of plates

We compute the modification in the spontaneous emission rate for a two-level atom when it is located between two parallel plates of different nature: a perfectly conducting plate $(\epsilon\to \infty)$ and an infinitely permeable one $(\mu\to \infty)$. We also discuss the case of two infinitely permeable plates. We compare our results with those found in the literature for the case of two perfectly conducting plates.Comment: latex file 4 pages, 4 figure

Energy-Momentum Tensor of Particles Created in an Expanding Universe

We present a general formulation of the time-dependent initial value problem for a quantum scalar field of arbitrary mass and curvature coupling in a FRW cosmological model. We introduce an adiabatic number basis which has the virtue that the divergent parts of the quantum expectation value of the energy-momentum tensor are isolated in the vacuum piece of , and may be removed using adiabatic subtraction. The resulting renormalized is conserved, independent of the cutoff, and has a physically transparent, quasiclassical form in terms of the average number of created adiabatic `particles'. By analyzing the evolution of the adiabatic particle number in de Sitter spacetime we exhibit the time structure of the particle creation process, which can be understood in terms of the time at which different momentum scales enter the horizon. A numerical scheme to compute as a function of time with arbitrary adiabatic initial states (not necessarily de Sitter invariant) is described. For minimally coupled, massless fields, at late times the renormalized goes asymptotically to the de Sitter invariant state previously found by Allen and Folacci, and not to the zero mass limit of the Bunch-Davies vacuum. If the mass m and the curvature coupling xi differ from zero, but satisfy m^2+xi R=0, the energy density and pressure of the scalar field grow linearly in cosmic time demonstrating that, at least in this case, backreaction effects become significant and cannot be neglected in de Sitter spacetime.Comment: 28 pages, Revtex, 11 embedded .ps figure