Predicting the Need for Biopsy to Detect Clinically Significant Prostate Cancer in Patients with a Magnetic Resonance Imaging–detected Prostate Imaging Reporting and Data System/Likert ≥3 Lesion: Development and Multinational External Validation of the Imperial Rapid Access to Prostate Imaging and Diagnosis Risk Score

Background: Although multiparametric magnetic resonance imaging (MRI) has highsensitivity, its lower specificity leads to a high prevalence of false-positive lesions requir-ing biopsy.Objective: To develop and externally validate a scoring system for MRI-detected ProstateImaging Reporting and Data System (PIRADS)/Likert 3 lesions containing clinically sig-nificant prostate cancer (csPCa).Design, setting, and participants: The multicentre Rapid Access to Prostate Imaging andDiagnosis (RAPID) pathway included 1189 patients referred to urology due to elevatedage-specific prostate-specific antigen (PSA) and/or abnormal digital rectal examination (DRE); April 27, 2017 to October 25, 2019.</p

Conservation and monitoring of invertebrates in terrestrial protected areas

Invertebrates constitute a substantial proportion of terrestrial and freshwater biodiversity and are critical to ecosystem function. However, their inclusion in biodiversity monitoring and conservation planning and management has lagged behind better-known, more widely appreciated taxa. Significant progress in invertebrate surveys, systematics and bioindication, both globally and locally, means that their use in biodiversity monitoring and conservation is becoming increasingly feasible. Here we outline challenges and solutions to the integration of invertebrates into biodiversity management objectives and monitoring in protected areas in South Africa. We show that such integration is relevant and possible, and assess the relative suitability of seven key taxa in this context. Finally, we outline a series of recommendations for mainstreaming invertebrates in conservation planning, surveys and monitoring in and around protected areas. Conservation implications: Invertebrates constitute a substantial and functionally significant component of terrestrial biodiversity and are valuable indicators of environmental condition. Although consideration of invertebrates has historically been neglected in conservation planning and management, substantial progress with surveys, systematics and bioindication means that it is now both feasible and advisable to incorporate them into protected area monitoring activities.Centre of Excellence for Invasion Biolog

Engineering in children's fiction: not a good story?

Responding to concerns that engineering is a poorly understood occupation and that young people are exposed to stereotyped images of scientists and engineers at an early age, this investigation sought to identify how science and engineering is portrayed in contemporary junior fiction (ages 8–12) and to what extent. An examination of 4,800 junior fiction titles in one region in New South Wales, Australia, identified as few as 71 titles that addressed themes related to engineering and the sciences. While the crazy, nerdy, scientific stereotype exists in these stories, mostly in humorous vein, we found that fictional characters were split between the nerdy, eccentric, and the more serious and professional types who were depicted as more popular. The emphasis was on male characters, but not exclusively so. There were limited details that could be associated with engineering. Where building, making, and working with machines featured, they were depicted as male activity and primarily connected to vehicles, mostly cars. We concluded that while young people, particularly girls, were unlikely to gain accurate or compelling images about engineering as an occupation from this source at present, as a medium for informing the young and their parents, the potential of fiction was considerable