Thermospheric winds and temperatures above Mawson, Antarctica, observed with an all-sky imaging, Fabry-Perot spectrometer

A new all-sky imaging Fabry-Perot spectrometer has been installed at Mawson station (67°36' S, 62°52' E), Antarctica. This instrument is capable of recording independent spectra from many tens of locations across the sky simultaneously. Useful operation began in March 2007, with spectra recorded on a total of 186 nights. Initial analysis has focused on the large-scale daily and average behavior of winds and temperatures derived from observations of the 630.0 nm airglow line of atomic oxygen, originating from a broad layer centered around 240 km altitude, in the ionospheric F-region. <br><br> The 1993 Horizontal Wind Model (HWM93), NRLMSISE-00 atmospheric model, and the Coupled Thermosphere/Ionosphere Plasmasphere (CTIP) model were used for comparison. During the geomagnetically quiet period studied, observed winds and temperatures were generally well modelled, although temperatures were consistently higher than NRLMSISE-00 predicted, by up to 100 K. CTIP temperatures better matched our data, particularly later in the night, but predicted zonal winds which were offset from those observed by 70–180 ms<sup>−1</sup> westward. During periods of increased activity both winds and temperatures showed much greater variability over time-scales of less than an hour. For the active night presented here, a period of 45 min saw wind speeds decrease by around 180 ms<sup>−1</sup>, and temperatures increase by approximately 100 K. Active-period winds were poorly modelled by HWM93 and CTIP, although observed median temperatures were in better agreement with NRLMSISE-00 during such periods. <br><br> Average behavior was found to be generally consistent with previous studies of thermospheric winds above Mawson. The collected data set was representative of quiet geomagnetic and solar conditions. Geographic eastward winds in the afternoon/evening generally continued until around local midnight, when winds turned equatorward. Geographic meridional and zonal winds in the afternoon were approximately 50 ms<sup>−1</sup> weaker than expected from HWM93, as was the transition to equatorward flow around midnight. There was also a negligible geographic zonal component to the post-midnight wind where HWM93 predicted strong westward flow. Average temperatures between 19:00 and 04:00 local solar time were around 60 K higher than predicted by NRLMSISE-00

A New Technique for Investigating Dust Charging in the PMSE Source Region

A new technique for investigating dust charging in the PMSE (polar mesospheric summer echoes) source region is proposed and discussed in this paper. The first high-frequency (HF) modulation of the PMSE with varying pump power was employed during a recent experimental campaign at EISCAT (European Incoherent Scatter Scientific Association). Two experiment setups including HF pump power stepping as well as quasi-continuous power sweeping were used. The experiment was designed based on a computational model capable of simulation of PMSE evolution during HF pump modulation in order to develop a new approach for studying the dust charging process in the PMSE source region. The charge state of dust particles along with background dusty plasma parameters is estimated using the experimental and computational results. A detailed future experimental design based on background dusty-plasma parameters is proposed. ©2020. American Geophysical Union. All Rights Reserved

Mesoscale observations of Joule heating near an auroral arc and ion-neutral collision frequency in the polar cap E region

We report on the first mesoscale combined ionospheric and thermospheric observations, partly in the vicinity of an auroral arc, from Svalbard in the polar cap on 2 February 2010. The EISCAT Svalbard radar employed a novel scanning mode in order to obtain F and E region ion flows over an annular region centered on the radar. Simultaneously, a colocated Scanning Doppler Imager observed the E region neutral winds and temperatures around 110 km altitude using the 557.7 nm auroral optical emission. Combining the ion and neutral data permits the E region Joule heating to be estimated with an azimuthal spatial resolution of ∼64 km at a radius of ∼163 km from the radar. The spatial distribution of Joule heating shows significant mesoscale variation. The ion-neutral collision frequency is measured in the E region by combining all the data over the entire field of view with only weak aurora present. The estimated ion-neutral collision frequency at ∼113 km altitude is in good agreement with the MSIS atmospheric model

Multi-frequency SuperDARN radar observations of the modulated ionosphere by high-power radio-waves at EISCAT

This paper presents the first joint observations of multi-frequency SuperDARN (Super Dual Auroral Radar Network) radar of the heated ionosphere by high-power high-frequency (HF) ground-based radio-waves along with the stimulated electromagnetic emissions (SEE) measurements. The unique heating experiment design at EISCAT (The European Incoherent Scatter Scientific Association) including fine frequency stepping through the fourth electron gyro-frequency (4f ce) provided the opportunity to directly determine the plasma waves responsible for SuperDARN radar echoes. Past experiments using a unique Kodiak SuperDARN receiver in Alaska with capability of data recording over a large bandwidth of frequencies different from the radar transmission frequency was able to detect some radar echoes due to pump-excited plasma waves. However, a precise characterization of these waves could not be reached in the past. Comparison of the behavior of the SEE data measured on the ground besides the multi-frequency SuperDARN observations above the heated ionosphere at EISCAT has shown a good correlation with the characteristics of upper-hybrid (UH)/electron Bernstein (EB) waves excited through parametric decay instability. The ray tracing model based on the EISCAT dynasonde data of the background ionospheric parameters has been used in order to determine the natural ionospheric effects on the propagation path of 9.9 MHz, 13.2 MHz, and 16.6 MHz signals associated with SuperDARN radar. By providing a more direct connection between SuperDARN echoes and the associated SEE measurements, this new technique potentially provides more quantitative characterization of plasma waves generated during ionospheric heating

Simultaneous Observations of a Sporadic E Layer by Digisonde and SuperDARN HF Radars at Zhongshan, Antarctica

Sporadic E (Es) layers could be composed of metallic ions and formed, modified, or transported by the action of convective electric fields in the high latitude ionosphere. In this paper, by utilizing simultaneous observations from Digisonde and Super Dual Auroral Radar Network (SuperDARN) HF radars at Zhongshan Station (ZHS, 69.4°S, 76.4°E), Antarctica, a thin Es layer, which initially formed in the lower F region and descended into the lower E region, with wavelike structures, was recorded by Digisonde on 14 November 2019. The Es layer-related concurrent ionospheric irregularities were also detected by the SuperDARN ZHS HF radar. By using a global-scale 2-D convection map, combined with images from the Special Sensor Ultraviolet Spectrographic Imager instruments onboard Defense Meteorological Satellite Program (DMSP) spacecraft, it is proposed that the flow shears associated with the duskside convective circulation are responsible for the evolution of the Es layer. Moreover, using the HF radar elevation angle data to measure the scatter height, it is strongly suggested that the Es layer was elongated with convection circulation. The electrodynamic processes responsible for the formation and evolution of the Es layer are discussed

Phase II Study of Radiotherapy and Temsirolimus versus Radiochemotherapy with Temozolomide in Patients with Newly Diagnosed Glioblastoma without MGMT Promoter Hypermethylation (EORTC 26082).

EORTC 26082 assessed the activity of temsirolimus in patients with newly diagnosed glioblastoma harboring an unmethylated O6 methylguanine-DNA-methyltransferase (MGMT) promoter. Patients (n = 257) fulfilling eligibility criteria underwent central MGMT testing. Patients with MGMT unmethylated glioblastoma (n = 111) were randomized 1:1 between standard chemo-radiotherapy with temozolomide or radiotherapy plus weekly temsirolimus (25 mg). Primary endpoint was overall survival at 12 months (OS12). A positive signal was considered >38 patients alive at 12 months in the per protocol population. A noncomparative reference arm of 54 patients evaluated the assumptions on OS12 in a standard-treated cohort of patients. Prespecified post hoc analyses of markers reflecting target activation were performed. Both therapies were administered per protocol with a median of 13 cycles of maintenance temsirolimus. Median age was 55 and 58 years in the temsirolimus and standard arms, the WHO performance status 0 or 1 for most patients (95.5%). In the per protocol population, 38 of 54 patients treated with temsirolimus reached OS12. The actuarial 1-year survival was 72.2% [95% confidence interval (CI), 58.2-82.2] in the temozolomide arm and 69.6% (95% CI, 55.8-79.9) in the temsirolimus arm [hazard ratio (HR) 1.16; 95% CI, 0.77-1.76; P = 0.47]. In multivariable prognostic analyses of clinical and molecular factors, phosphorylation of mTORSer2448 in tumor tissue (HR 0.13; 95% CI, 0.04-0.47; P = 0.002), detected in 37.6%, was associated with benefit from temsirolimus. Temsirolimus was not superior to temozolomide in patients with an unmethylated MGMT promoter. Phosphorylation of mTORSer2448 in the pretreatment tumor tissue may define a subgroup benefitting from mTOR inhibition. Clin Cancer Res; 22(19); 4797-806. ©2016 AACR

Phase II Study of Radiotherapy and Temsirolimus versus Radiochemotherapy with Temozolomide in Patients with Newly Diagnosed Glioblastoma without MGMT Promoter Hypermethylation (EORTC 26082).

EORTC 26082 assessed the activity of temsirolimus in patients with newly diagnosed glioblastoma harboring an unmethylated O6 methylguanine-DNA-methyltransferase (MGMT) promoter. Patients (n = 257) fulfilling eligibility criteria underwent central MGMT testing. Patients with MGMT unmethylated glioblastoma (n = 111) were randomized 1:1 between standard chemo-radiotherapy with temozolomide or radiotherapy plus weekly temsirolimus (25 mg). Primary endpoint was overall survival at 12 months (OS12). A positive signal was considered >38 patients alive at 12 months in the per protocol population. A noncomparative reference arm of 54 patients evaluated the assumptions on OS12 in a standard-treated cohort of patients. Prespecified post hoc analyses of markers reflecting target activation were performed. Both therapies were administered per protocol with a median of 13 cycles of maintenance temsirolimus. Median age was 55 and 58 years in the temsirolimus and standard arms, the WHO performance status 0 or 1 for most patients (95.5%). In the per protocol population, 38 of 54 patients treated with temsirolimus reached OS12. The actuarial 1-year survival was 72.2% [95% confidence interval (CI), 58.2-82.2] in the temozolomide arm and 69.6% (95% CI, 55.8-79.9) in the temsirolimus arm [hazard ratio (HR) 1.16; 95% CI, 0.77-1.76; P = 0.47]. In multivariable prognostic analyses of clinical and molecular factors, phosphorylation of mTORSer2448 in tumor tissue (HR 0.13; 95% CI, 0.04-0.47; P = 0.002), detected in 37.6%, was associated with benefit from temsirolimus. Temsirolimus was not superior to temozolomide in patients with an unmethylated MGMT promoter. Phosphorylation of mTORSer2448 in the pretreatment tumor tissue may define a subgroup benefitting from mTOR inhibition. Clin Cancer Res; 22(19); 4797-806. ©2016 AACR

Dynamic Properties of a Sporadic Sodium Layer Revealed by Observations Over Zhongshan, Antarctica:A Case Study

A sodium Doppler lidar system with three-directional measurements of sodium density, atmospheric wind field, and temperature was established at Zhongshan (69.4°S, 76.4°E), Antarctica. On November 14, 2019, a sporadic sodium layer (SSL) was observed at an altitude range of 93–103 km. The temporal/spatial sodium density variations of this SSL are associated with a strong sporadic E (Es) layer at nearly the same height, which is modulated by the convective electric field. By considering the structures and the time lags of the SSL's growth at three positions, the SSL appears to have a horizontal advection in an approximately westward direction with a velocity of the order of 80 m/s. This is consistent with the zonal wind velocity derived from the lidar system itself. The temporal/spatial sodium density variations strongly indicate that the formation and perturbation of SSLs are related to the evolution of ES layers due to varied electric fields and atmospheric gravity waves, while it is advected by the horizontal wind

OI 630.0-nm and N2 1PG Emissions in Pulsating Aurora Events Observed by an Optical Spectrograph at Tromsø, Norway

We performed observations of pulsating aurora (PsA) with an optical spectrograph at Tromsø, Norway, during wintertime in 2016–2017. The data analysis of multiple PsA events revealed the PsA spectra for the first time. As the results, the OI 630.0-nm emissions and the N2 1PG emissions were found in the both spectra during brighter (ON) and darker (OFF) phases in the PsA events. The spectra of pulsations were derived as difference spectra between the ON and OFF spectra. From the obtained spectra of pulsations, it is found that dominant pulsations at 630.0 nm were coming from the N2 1PG (10,7) band, and there were less or minor contributions of the OI 630.0 nm to pulsations at 630.0 nm