16 research outputs found
Measuring Black Hole Spin in OJ287
We model the binary black hole system OJ287 as a spinning primary and a
non-spinning secondary. It is assumed that the primary has an accretion disk
which is impacted by the secondary at specific times. These times are
identified as major outbursts in the light curve of OJ287. This identification
allows an exact solution of the orbit, with very tight error limits. Nine
outbursts from both the historical photographic records as well as from recent
photometric measurements have been used as fixed points of the solution: 1913,
1947, 1957, 1973, 1983, 1984, 1995, 2005 and 2007 outbursts. This allows the
determination of eight parameters of the orbit. Most interesting of these are
the primary mass of , the secondary mass , major axis precession rate per period, and the
eccentricity of the orbit 0.70. The dimensionless spin parameter is
(1 sigma). The last parameter will be more tightly
constrained in 2015 when the next outburst is due. The outburst should begin on
15 December 2015 if the spin value is in the middle of this range, on 3 January
2016 if the spin is 0.25, and on 26 November 2015 if the spin is 0.31. We have
also tested the possibility that the quadrupole term in the Post Newtonian
equations of motion does not exactly follow Einstein's theory: a parameter
is introduced as one of the 8 parameters. Its value is within 30% (1 sigma) of
the Einstein's value . This supports the of black
holes within the achievable precision. We have also measured the loss of
orbital energy due to gravitational waves. The loss rate is found to agree with
Einstein's value with the accuracy of 2% (1 sigma).Comment: 12 pages, 4 figures, IAU26
ACKR4 restrains antitumor immunity by regulating CCL21
Current immunotherapies involving CD8⁺ T cell responses show remarkable promise, but their efficacy in many solid tumors is limited, in part due to the low frequency of tumor-specific T cells in the tumor microenvironment (TME). Here, we identified a role for host atypical chemokine receptor 4 (ACKR4) in controlling intratumor T cell accumulation and activation. In the absence of ACKR4, an increase in intratumor CD8⁺ T cells inhibited tumor growth, and nonhematopoietic ACKR4 expression was critical. We show that ACKR4 inhibited CD103⁺ dendritic cell retention in tumors through regulation of the intratumor abundance of CCL21. In addition, preclinical studies indicate that ACKR4 and CCL21 are potential therapeutic targets to enhance responsiveness to immune checkpoint blockade or T cell costimulation.Carly E. Whyte, Maleika Osman, Ervin E. Kara, Caitlin Abbott, Jade Foeng, Duncan R. McKenzie, Kevin A. Fenix, Yuka Harata-Lee, Kerrie L. Foyle, Sarah T. Boyle, Marina Kochetkova, Amelia Roman Aguilera, Jiajie Hou, Xian-Yang Li, Mark A. Armstrong, Stephen M. Pederson, Iain Comerford, Mark J. Smyth, and Shaun R. McCol