Training of Future Education Managers For Professional Activities

Large-scale changes in the social and economic spheres of Russian society revealed the demands for managers with non-standard thinking and a high cultural level. Specific and ambiguous processes in politic, economic and social spheres in different parts of the world have general trends reflecting the evolution of global civilization. In this context, educational systems received new functions aimed at moral growth and improvement of competencies. The highest demand in the field of education is for experienced teachers and administrators who are able to improve the system of education and upbringing, develop scenarios for managing the teaching and learning process, offer the personality-oriented trajectories for students, make an independent choice and fulfill corrective and diagnostic functions. The transformed socioeconomic context led to positive changes in the field of professional education. One of the basic features of the modern educational systems is the training of highly qualified education managers. Such individual characteristics as the ability to continuous self-improvement, creativity, communication skills, entrepreneurial skills, the ability to analyze and foresee, etc. play an increasing role in the professional training. The most important place in the training of education managers is occupied by pedagogical technologies aimed at mastering the necessary competencies in economics, management, psychology and related disciplines. In the context of the innovative transformations of Russian education, the pressing need to integrate new management schemes into the practice of educational institutions and the problem of pedagogical training in the field of management becomes very urgent. Qualified management creates conditions for improving the educational environment, increasing the quality of educational services. The educational system should prepare young citizens capable of making a feasible contribution to the formation of the law-based state. Currently, it is necessary to optimize the activities of education managers responsible for the implementation of the state programs to improve and innovate the economy, science and education. The management culture of education managers is beginning to play a decisive role in the creation of a democratic society in the Russian Federation based on respect for individual rights and freedoms. The creation of the most favorable conditions for the integration of students into the educational and cultural environment is aimed at creating a high level of management culture of future education managers

FN3 protein fragment containing two type III fibronectin domains from B. longum GT15 binds to human tumor necrosis factor alpha in vitro

Most species of the genus Bifidobacterium contain the gene cluster PFNA, which is presumably involved in the species-specific communication between bacteria and their hosts. The gene cluster PFNA consists of five genes including fn3, which codes for a protein containing two fibronectin type III domains. Each fibronectin domain contains sites similar to cytokine-binding sites of human receptors. Based on this finding we assumed that this protein would bind specifically to human cytokines in vitro. We cloned a fragment of the fn3 gene (1503 bp; 501 aa) containing two fibronectin domains, from the strain B. longum subsp. longum GT15. After cloning the fragment into the expression vector pET16b and expressing it in E. coli, the protein product was purified to a homogenous state for further analysis. Using the immunoferment method, we tested the purified fragment's ability to bind the following human cytokines: IL-1β, IL-6, IL-10, TNFα. We developed a sandwich ELISA system to detect any specific interactions between the purified protein and any of the studied cytokines. We found that the purified protein fragment only binds to TNFα. © 2020 Elsevier Lt