Rapid-response radio observations of short GRB 181123B with the Australia Telescope Compact Array

We introduce the Australia Telescope Compact Array (ATCA) rapid-response mode by presenting the first successful trigger on the short-duration gamma-ray burst (GRB) 181123B. Early-time radio observations of short GRBs may provide vital insights into the radio afterglow properties of Advanced LIGO- and Virgo-detected gravitational wave events, which will in turn inform follow-up strategies to search for counterparts within their large positional uncertainties. The ATCA was on target within 12.6 hr post-burst, when the source had risen above the horizon. While no radio afterglow was detected during the 8.3 hr observation, we obtained force-fitted flux densities of $7 \pm 12$ and $15 \pm 11~\mu$Jy at 5.5 and 9 GHz, respectively. Afterglow modelling of GRB 181123B showed that the addition of the ATCA force-fitted radio flux densities to the Swift X-ray Telescope detections provided more stringent constraints on the fraction of thermal energy in the electrons (log$\epsilon_e = -0.75^{+0.39}_{-0.40}$ rather than log$\epsilon_e = -1.13^{+0.82}_{-1.2}$ derived without the inclusion of the ATCA values), which is consistent with the range of typical $\epsilon_e$ derived from GRB afterglow modelling. This allowed us to predict that the forward shock may have peaked in the radio band $\sim10$ days post-burst, producing detectable radio emission $\gtrsim3-4$ days post-burst. Overall, we demonstrate the potential for extremely rapid radio follow-up of transients and the importance of triggered radio observations for constraining GRB blast wave properties, regardless of whether there is a detection, via the inclusion of force-fitted radio flux densities in afterglow modelling efforts.Comment: 15 pages, 7 figures, accepted for publication in MNRA

Rapid-response radio observations of short GRB 181123B with the Australia Telescope Compact Array

We introduce the Australia Telescope Compact Array (ATCA) rapid-response mode by presenting the first successful trigger on the short-duration gamma-ray burst (GRB) 181123B. Early-time radio observations of short GRBs may provide vital insights into the radio afterglow properties of Advanced LIGO- and Virgo-detected gravitational wave events, which will in turn inform follow-up strategies to search for counterparts within their large positional uncertainties. The ATCA was on target within 12.6 hr post-burst, when the source had risen above the horizon. While no radio afterglow was detected during the 8.3 hr observation, we obtained force-fitted flux densities of $7 \pm 12$ and $15 \pm 11~\mu$Jy at 5.5 and 9 GHz, respectively. Afterglow modelling of GRB 181123B showed that the addition of the ATCA force-fitted radio flux densities to the Swift X-ray Telescope detections provided more stringent constraints on the fraction of thermal energy in the electrons (log$\epsilon_e = -0.75^{+0.39}_{-0.40}$ rather than log$\epsilon_e = -1.13^{+0.82}_{-1.2}$ derived without the inclusion of the ATCA values), which is consistent with the range of typical $\epsilon_e$ derived from GRB afterglow modelling. This allowed us to predict that the forward shock may have peaked in the radio band $\sim10$ days post-burst, producing detectable radio emission $\gtrsim3-4$ days post-burst. Overall, we demonstrate the potential for extremely rapid radio follow-up of transients and the importance of triggered radio observations for constraining GRB blast wave properties, regardless of whether there is a detection, via the inclusion of force-fitted radio flux densities in afterglow modelling efforts

Genotype-Phenotype Correlation in NF1: Evidence for a More Severe Phenotype Associated with Missense Mutations Affecting NF1 Codons 844–848

Neurofibromatosis type 1 (NF1), a common genetic disorder with a birth incidence of 1:2,000–3,000, is characterized by a highly variable clinical presentation. To date, only two clinically relevant intragenic genotype-phenotype correlations have been reported for NF1 missense mutations affecting p.Arg1809 and a single amino acid deletion p.Met922del. Both variants predispose to a distinct mild NF1 phenotype with neither externally visible cutaneous/plexiform neurofibromas nor other tumors. Here, we report 162 individuals (129 unrelated probands and 33 affected relatives) heterozygous for a constitutional missense mutation affecting one of five neighboring NF1 codons—Leu844, Cys845, Ala846, Leu847, and Gly848—located in the cysteine-serine-rich domain (CSRD). Collectively, these recurrent missense mutations affect ∼0.8% of unrelated NF1 mutation-positive probands in the University of Alabama at Birmingham (UAB) cohort. Major superficial plexiform neurofibromas and symptomatic spinal neurofibromas were more prevalent in these individuals compared with classic NF1-affected cohorts (both p < 0.0001). Nearly half of the individuals had symptomatic or asymptomatic optic pathway gliomas and/or skeletal abnormalities. Additionally, variants in this region seem to confer a high predisposition to develop malignancies compared with the general NF1-affected population (p = 0.0061). Our results demonstrate that these NF1 missense mutations, although located outside the GAP-related domain, may be an important risk factor for a severe presentation. A genotype-phenotype correlation at the NF1 region 844–848 exists and will be valuable in the management and genetic counseling of a significant number of individuals

Implementation of Approximation Algorithms for the Max-Min Resource Sharing Problem

Abstract. We implement the algorithm for the max-min resource sharing problem described in [7], using a new line search technique for determining a suitable step length. Our line search technique uses a modified potential function that is less costly to evaluate, thus heuristically simplifying the computation. Observations concerning the quality of the dual solution and oscillating behavior of the algorithm are made. First numerical observations are briefly discussed. In particular we study a certain class of linear programs, namely the computational bottleneck of an algorithm from [8] for solving strip packing with an approach from [10, 13]. For these, we obtain practical running times. Our implementation is able to solve instances for small accuracy parameters ɛ for which the methods proposed in theory are out of practical interest. More precisely, the technique from [8] improves the known runtime bound of O(M 6 ln 2 (Mn/(at))+M 5 n/t+ln(Mn/(at))) to the more favourable bound O(M(ɛ −3 (ɛ −2 +lnM)+M(ɛ −2 +lnM))), where n denotes the number of items, M the number of distinct item widths, a the width of the narrowest item and t is a desired additive tolerance. Keywords