The Elusive Majority of Young Moving Groups. I. Young Binaries and Lithium-rich Stars in the Solar Neighborhood

Young stars in the solar neighborhood serve as nearby probes of stellar evolution and represent promising targets to directly image self-luminous giant planets. We have carried out an all-sky search for late-type (≈K7-M5) stars within 100 pc selected primarily on the basis of activity indicators from the Galaxy Evolution Explorer and ROSAT. Approximately 2000 active and potentially young stars are identified, of which we have followed up over 600 with low-resolution optical spectroscopy and over 1000 with diffraction-limited imaging using Robo-AO at the Palomar 1.5 m telescope. Strong lithium is present in 58 stars, implying ages spanning ≈10-200 Myr. Most of these lithium-rich stars are new or previously known members of young moving groups including TWA, β Pic, Tuc-Hor, Carina, Columba, Argus, AB Dor, Upper Centaurus Lupus, and Lower Centaurus Crux; the rest appear to be young low-mass stars without connections to established kinematic groups. Over 200 close binaries are identified down to 0.″2 - the vast majority of which are new - and will be valuable for dynamical mass measurements of young stars with continued orbit monitoring in the future

An Adaptive Optics Census of Companions to Northern Stars Within 25 pc with Robo-AO

In order to assess the multiplicity statistics of stars across spectral types and populations in a volume-limited sample, we censused nearby stars for companions with Robo-AO. We report on observations of 1157 stars of all spectral types within 25 pc with decl. >-13° searching for tight companions. We detected 154 companion candidates with separations ranging from ∼0.″15 to 4.″0 and magnitude differences up to "m i′≤7 using the robotic adaptive optics instrument Robo-AO. We confirmed physical association from Gaia EDR3 astrometry for 53 of the companion candidates, 99 remain to be confirmed, and two were ruled out as background objects. We complemented the high-resolution imaging companion search with a search for comoving objects with separations out to 10,000 au in Gaia EDR3, which resulted in an additional 147 companions registered. Of the 301 total companions reported in this study, 49 of them are new discoveries. Out of the 191 stars with significant acceleration measurements in the Hipparcos-Gaia catalog of accelerations, we detect companions around 115 of them, with the significance of the acceleration increasing as the companion separation decreases. From this survey, we report the following multiplicity fractions (compared to literature values): 40.9% ± 3.0% (44%) for FGK stars and 28.2% ± 2.3% (27%) for M stars, as well as higher-order fractions of 5.5% ± 1.1% (11%) and 3.9% ± 0.9% (5%) for FGK stars and M-type stars, respectively

Large adaptive optics survey for substellar objects around Young, Nearby, Low-mass Stars with Robo-AO

We present results from the Large Adaptive optics Survey for Substellar Objects, where the goal is to directly image new substellar companions (<70 MJup) at wide orbital separations (≳50 au) around young (≲300 Myr), nearby (<100 pc), low-mass (≈0.1–0.8 M☉) stars. We report on 427 young stars imaged in the visible (i′) and near-infrared (J or H) simultaneously with Robo-AO on the Kitt Peak 2.1 m telescope and later the Maunakea University of Hawaii 2.2 m telescope. To undertake the observations, we commissioned a new infrared camera for Robo-AO that uses a low-noise high-speed SAPHIRA avalanche photodiode detector. We detected 121 companion candidates around 111 stars, of which 62 companions are physically associated based on Gaia DR2 parallaxes and proper motions, another 45 require follow-up observations to confirm physical association, and 14 are background objects. The companion separations range from 2 to 1101 au and reach contrast ratios of 7.7 mag in the near-infrared compared to the primary. The majority of confirmed and pending candidates are stellar companions, with ∼5 being potentially substellar and requiring follow-up observations for confirmation. We also detected a 43 ± 9 MJup and an 81 ± 5 MJup companion that were previously reported. We found 34 of our targets have acceleration measurements detected using Hipparcos–Gaia proper motions. Of those, 58-+1412% of the 12 stars with imaged companion candidates have significant accelerations (c2 > 11.8), while only 23-+611% of the remaining 22 stars with no detected companion have significant accelerations. The significance of the acceleration decreases with increasing companion separation. These young accelerating low-mass stars with companions will eventually yield dynamical masses with future orbit monitoring

Enhanced glycemic control with combination therapy for type 2 diabetes in primary care

Type 2 diabetes mellitus is an increasingly common medical problem for primary care clinicians to address. Treatment of diabetes has evolved from simple replacement of insulin (directly or through insulin secretagogs) through capture of mechanisms such as insulin sensitizers, alpha-glucosidase inhibitors, and incretins. Only very recently has recognition of the critical role of the gastrointestinal system as a major culprit in glucose dysregulation been established. Since glycated hemoglobin A1c reductions provide meaningful risk reduction as well as improved quality of life, it is worthwhile to explore evolving paths for more efficient use of the currently available pharmacotherapies. Because diabetes is a progressive disease, even transiently successful treatment will likely require augmentation as the disorder progresses. Pharmacotherapies with complementary mechanisms of action will be necessary to achieve glycemic goals. Hence, clinicians need to be well informed about the various noninsulin alternatives that have been shown to be successful in glycemic goal attainment. This article reviews the benefits of glucose control, the current status of diabetes control, pertinent pathophysiology, available pharmacological classes for combination, limitations of current therapies, and suggestions for appropriate combination therapies, including specific suggestions for thresholds at which different strategies might be most effectively utilized by primary care clinicians

Isotopic signatures of methane emissions from tropical fires, agriculture and wetlands: the MOYA and ZWAMPS flights

We report methane isotopologue data from aircraft and ground measurements in Africa and South America. Aircraft campaigns sampled strong methane fluxes over tropical papyrus wetlands in the Nile, Congo and Zambezi basins, herbaceous wetlands in Bolivian southern Amazonia, and over fires in African woodland, cropland and savannah grassland. Measured methane δ13CCH4 isotopic signatures were in the range −55 to −49‰ for emissions from equatorial Nile wetlands and agricultural areas, but widely −60 ± 1‰ from Upper Congo and Zambezi wetlands. Very similar δ13CCH4 signatures were measured over the Amazonian wetlands of NE Bolivia (around −59‰) and the overall δ13CCH4 signature from outer tropical wetlands in the southern Upper Congo and Upper Amazon drainage plotted together was −59 ± 2‰. These results were more negative than expected. For African cattle, δ13CCH4 values were around −60 to −50‰. Isotopic ratios in methane emitted by tropical fires depended on the C3 : C4 ratio of the biomass fuel. In smoke from tropical C3 dry forest fires in Senegal, δ13CCH4 values were around −28‰. By contrast, African C4 tropical grass fire δ13CCH4 values were −16 to −12‰. Methane from urban landfills in Zambia and Zimbabwe, which have frequent waste fires, had δ13CCH4 around −37 to −36‰. These new isotopic values help improve isotopic constraints on global methane budget models because atmospheric δ13CCH4 values predicted by global atmospheric models are highly sensitive to the δ13CCH4 isotopic signatures applied to tropical wetland emissions. Field and aircraft campaigns also observed widespread regional smoke pollution over Africa, in both the wet and dry seasons, and large urban pollution plumes. The work highlights the need to understand tropical greenhouse gas emissions in order to meet the goals of the UNFCCC Paris Agreement, and to help reduce air pollution over wide regions of Africa

Partitioning the Heritability of Tourette Syndrome and Obsessive Compulsive Disorder Reveals Differences in Genetic Architecture

The direct estimation of heritability from genome-wide common variant data as implemented in the program Genome-wide Complex Trait Analysis (GCTA) has provided a means to quantify heritability attributable to all interrogated variants. We have quantified the variance in liability to disease explained