Differential Behavioral Responses to\ud Cocaethylene of Long-Evans and\ud Sprague-Dawley Rats: Role of Serotonin

Cocaethylene is a neuroactive metabolite derived from the concurrent consumption of cocaine and ethanol. The effects of cocaethylene on locomotor activity, stereotypy, and rearing in Long-Evans and Sprague-Dawley rats were compared.A single cocaine injection (molar equivalent of 60 μmol/kg cocaethylene, intraperitoneal) elicited a robust series of motor output behaviors, including locomotion, stereotypy, and rearing over a 30-minute testing period in Long-Evans rats. In contrast, cocaethylene administration,\ud under comparable testing conditions, produced no significant changes in locomotor and investigatory behaviors. Because cocaethylene has relatively little impact on serotonin (5-HT) reuptake as opposed to reuptake of dopamine, we pretreated Long-Evans rats with fluoxetine (10 mg/kg; IP), a selective 5-HT reuptake inhibitor. Fluoxetine profoundly augmented cocaethylene-stimulated behaviors in this rat phenotype. To examine whether other rat strains exhibit a similar response to cocaethylene, Sprague-Dawley rats were injected (IP) with cocaethylene and their behavior patterns monitored over a 30-minute testing period. Cocaethylene produced marked locomotor and exploratory behaviors in this strain, suggesting therefore that Long-Evans and Sprague-\ud Dawley rats differ in their response to cocaethylene. To relate these behavioral differences to possible structural differences in the neuronal density of dopaminergic or\ud serotonergic neurons, Long-Evans and Sprague-Dawley brains were evaluated for tyrosine hydroxylase and 5-HT immunocytochemistry. No gross morphological differences\ud in neuronal architecture or density were found in the ventral tegmental area or dorsal raphe nucleus of the two rat phenotypes. These results indicate that two commonly used rat strains show a differential response to cocaethylene and the neurochemical basis for this behavioral difference may be related to synaptic 5-HT bioavailability

Effects of cocaethylene on dopamine and serotonin synthesis in Long–Evans and Sprague–Dawley brains

We examined the behavioral and neurochemical effects of cocaethylene treatment in Long–Evans (�LE). and Sprague–Dawley� (SD) rats. Cocaethylene-induced behaviors were significantly less in LE rats. Cocaethylene caused an inhibition of dopamine synthesis in the caudate nucleus and nucleus accumbens that was equivalent in both rat lines. Serotonin synthesis was also suppressed by cocaethylene treatment, however this phenomenon was less pronounced when compared with the effects on dopamine synthesis

Dopaminergic, glutamatergic but not opioidergic mechanisms mediate induction of FOS-like protein by cocaethylene

Cocaethylene is a psychoactive metabolite formed\ud during the combined consumption of cocaine and ethanol. As\ud this metabolite has many properties in common with cocaine, it is conceivable that cocaethylene administration may induce the activity of nuclear transcription factors that regulate the expression of late-response genes. Therefore, the temporal induction of FOS-like protein in rat brain was examined following IP administration of 60 mmol/kg cocaethylene. Immunoreactivity for the protein was detectable at 1 h in striatal neurons and had virtually disappeared 6 h after drug treatment. Administration of\ud specific dopaminergic (SCH-23390; 0.5 mg/kg) and glutamatergic (MK-801; 1 mg/kg) receptor antagonists prior to cocaethylene indicated a significant role for dopamine (D1) and Nmethyl-D-aspartate receptor subtypes in mediating the nuclear induction of the aforementioned transcription factor protein. In contrast, no significant effects on FOS-like protein in discrete neurons of the caudate putamen were found when spiradoline (U-62066), a kappa opioid-receptor agonist, was administered either IP (10 mg/kg) or directly (50 nmol) into the brain parenchyma. In addition, we uncovered a differential sensitivity of Long–Evans rats to the behavioral effects of cocaethylene, with the psychoactive metabolite producing significantly less behavioral activity (e.g., locomotion, rearing, and continuous sniffing)than that produced by cocaine (molar equivalent of 60 mmol/kg cocaethylene). These findings indicate both common and disparate effects of cocaethylene and its parent compound, cocaine, on receptor pathways that regulate target alterations in gene expression and drug-induced motor behavior

Exactly solvable model of superstring in Ramond-Ramond plane wave background

We describe in detail the solution of type IIB superstring theory in the maximally supersymmetric plane-wave background with constant null Ramond-Ramond 5-form field strength. The corresponding light-cone Green-Schwarz action found in hep-th/0112044 is quadratic in both bosonic and fermionic coordinates. We find the spectrum of the light-cone Hamiltonian and the string representation of the supersymmetry algebra. The superstring Hamiltonian has a ``harmonic-oscillator'' form in both the string-oscillator and the zero-mode parts and thus has discrete spectrum in all 8 transverse directions. We analyze the structure of the zero-mode sector of the theory, establishing the precise correspondence between the lowest-lying ``massless'' string states and the type IIB supergravity fluctuation modes in the plane-wave background. The zero-mode spectrum has certain similarity to the supergravity spectrum in AdS_5 x S^5 of which the plane-wave background is a special limit. We also compare the plane-wave string spectrum with expected form of the light-cone gauge spectrum of superstring in AdS_5 x S^5.Comment: 33 pages, latex. v4: minor sign corrections in (1.5) and (3.62), to appear in PR

Parity-Violating Electron Scattering from the Pion-Correlated Relativistic Fermi Gas

Parity-violating quasielastic electron scattering is studied within the context of the relativistic Fermi gas and its extensions to include the effects of pionic correlations and meson-exchange currents. The work builds on previous studies using the same model; here the part of the parity-violating asymmetry that contains axial-vector hadronic currents is developed in detail using those previous studies and a link is provided to the transverse vector-isovector response. Various integrated observables are constructed from the differential asymmetry. These include an asymmetry averaged over the quasielastic peak, as well as the difference of the asymmetry integrated to the left and right of the peak -- the latter is shown to be optimal for bringing out the nature of the pionic correlations. Special weighted integrals involving the differential asymmetry and electromagnetic cross section, based on the concepts of y-scaling and sum rules, are constructed and shown to be suited to studies of the single-nucleon form factor content in the problem, in particular, to determinations of the isovector/axial-vector and electric strangeness form factors. Comparisons are also made with recent predictions made on the basis of relativistic mean-field theory.Comment: 28 pages, LATeX, 13 figures (tar-compressed postscript files, available from the authors), MIT preprint CTP#222

Decay of long-lived massive closed superstring states: Exact results

We find a one-parameter family of long-lived physical string states in type II superstring theory. We compute the decay rate by an exact numerical evaluation of the imaginary part of the one-loop propagator. Remarkably, the lifetime rapidly increases with the mass. We find a power-law dependence of the form $T = const. g^{-2} Mass^\alpha$, where the value of $\alpha$ depends on the parameter characterizing the state. For the most stable state in this family, one has $\alpha ~= 5$. The dominant decay channel of these massive string states is by emission of soft massless particles. The quantum states can be viewed semiclassically as closed strings which cannot break during the classical evolution.Comment: Latex, 5 figures, 35 pages (= 23 pages + appendices). Minor correction

Alternative Signature of TeV Strings

In string theory, it is well known that any hard scattering amplitude inevitably suffers exponential suppression. We demonstrate that, if the string scale is M_s < 2TeV, this intrinsically stringy behavior leads to a dramatic reduction in the QCD jet production rate with very high transverse momenta p_T > 2TeV at LHC. This suppression is sufficient to be observed in the first year of low-luminosity running. Our prediction is based on the universal behavior of string theory, and therefore is qualitatively model-independent. This signature is alternative and complementary to conventional ones such as Regge resonance (or string ball/black hole) production.Comment: a note added; version to appear in Phys. Rev. D; 11 pages, 1 eps figure, LaTeX2e; BibTeX with utphys style use

Duality of Type II 7-branes and 8-branes

We present a version of ten-dimensional IIA supergravity containing a 9-form potential for which the field equations are equivalent to those of the standard, massless, IIA theory for vanishing 10-form field strength, $F_{10}$, and to those of the `massive' IIA theory for non-vanishing $F_{10}$. We present a multi 8-brane solution of these equations that generalizes the 8-brane of Polchinski and Witten. We show that this solution is T-dual to a new multi 7-brane solution of $S^1$ compactified IIB supergravity, and that the latter is T-dual to the IIA 6-brane. When combined with the $Sl(2;\Z)$ U-duality of the type IIB superstring, the T-duality between type II 7-branes and 8-branes implies a quantization of the cosmological constant of type IIA superstring theory. These results are made possible by the construction of a new {\it massive} N=2 D=9 supergravity theory. We also discuss the 11-dimensional interpretation of these type II p-branes.Comment: Includes corrections to last section that will appear in the version to be published in Nuclear Physics B. 36 pp. Phyzz

Wavy Strings: Black or Bright?

Recent developments in string theory have brought forth a considerable interest in time-dependent hair on extended objects. This novel new hair is typically characterized by a wave profile along the horizon and angular momentum quantum numbers $l,m$ in the transverse space. In this work, we present an extensive treatment of such oscillating black objects, focusing on their geometric properties. We first give a theorem of purely geometric nature, stating that such wavy hair cannot be detected by any scalar invariant built out of the curvature and/or matter fields. However, we show that the tidal forces detected by an infalling observer diverge at the `horizon' of a black string superposed with a vibration in any mode with $l \ge 1$. The same argument applied to longitudinal ($l=0$) waves detects only finite tidal forces. We also provide an example with a manifestly smooth metric, proving that at least a certain class of these longitudinal waves have regular horizons.Comment: 45 pages, latex, no figure

Introduction to M Theory and AdS/CFT Duality

An introductory survey of some of the developments that have taken place in superstring theory in the past few years is presented. The main focus is on three particular dualities. The first one is the appearance of an 11th dimension in the strong coupling limit of the type IIA theory, which give rise to M theory. The second one is the duality between the type IIB theory compactified on a circle and M theory on a two-torus. The final topic is an introduction to the recently proposed duality between superstring theory or M theory on certain anti de Sitter space backgrounds and conformally invariant quantum field theories.Comment: 26 pages; To be published in the Proceedings of a conference held in Corfu, Greece in September 1998. v2: reference adde