The mechanics of trust: a framework for research and design

With an increasing number of technologies supporting transactions over distance and replacing traditional forms of interaction, designing for trust in mediated interactions has become a key concern for researchers in human computer interaction (HCI). While much of this research focuses on increasing users’ trust, we present a framework that shifts the perspective towards factors that support trustworthy behavior. In a second step, we analyze how the presence of these factors can be signalled. We argue that it is essential to take a systemic perspective for enabling well-placed trust and trustworthy behavior in the long term. For our analysis we draw on relevant research from sociology, economics, and psychology, as well as HCI. We identify contextual properties (motivation based on temporal, social, and institutional embeddedness) and the actor's intrinsic properties (ability, and motivation based on internalized norms and benevolence) that form the basis of trustworthy behavior. Our analysis provides a frame of reference for the design of studies on trust in technology-mediated interactions, as well as a guide for identifying trust requirements in design processes. We demonstrate the application of the framework in three scenarios: call centre interactions, B2C e-commerce, and voice-enabled on-line gaming

Monitoring Handbook 4: Monitoring ecological effects

The goal of restoration should be to create a self-sustaining ecosystem that functions well and needs little maintenance. Monitoring is essential in order to see if projects are achieving improved ecological conditions. Part 1 of this handbook includes a description of common restoration goals and indicators. Methods for measuring each indicator are described in Part 2

Monitoring Handbook 1: What is multiparty monitoring?

There are many reasons for monitoring your project and using a multiparty approach. Multiparty monitoring will increase your understanding of the effects of restoration actions, support adaptive management, and set a course for future management. Multiparty monitoring also helps build trust among partners and establish project accountability in the broader community. This handbook will guide you through the initial steps required to develop a multiparty monitoring process

Monitoring Handbook 5: Monitoring social and economic effects of forest restoration

Forest restoration projects frequently have social, economic, and cultural goals as well as ecological goals. For instance, project partners may hope that their project will provide new jobs and reduce local unemployment, keep youth in the community, reduce the wildfire risk to human lives and property, or increase public involvement in national forest planning and decision making. Monitoring provides a way to determine whether you are headed toward or away from these goals. For example, your monitoring group might want to ask, Is our community becoming more or less sustainable? Are local management skills improving or getting worse? or Is the use of small-diameter trees increasing or decreasing? Part 1 of this handbook describes indicators that can help community-based multiparty monitoring groups measure changes in common forest restoration project goals. Part 2 describes specific methods for measuring change in each indicator

Tunneling broadening of vibrational sidebands in molecular transistors

Transport through molecular quantum dots coupled to a single vibration mode is studied in the case with strong coupling to the leads. We use an expansion in the correlation between electrons on the molecule and electrons in the leads and show that the tunneling broadening is strongly suppressed by the combination of the Pauli principle and the quantization of the oscillator. As a consequence the first Frank-Condon step is sharper than the higher order ones, and its width, when compared to the bare tunneling strength, is reduced by the overlap between the groundstates of the displaced and the non-displaced oscillator.Comment: 8 pages, 3 figures. PRB, in pres

Elastic Scattering of Pions From the Three-nucleon System

We examine the scattering of charged pions from the trinucleon system at a pion energy of 180 MeV. The motivation for this study is the structure seen in the experimental angular distribution of back-angle scattering for pi+ 3He and pi- 3H but for neither pi- 3He nor pi+ 3H. We consider the addition of a double spin flip term to an optical model treatment and find that, though the contribution of this term is non-negligible at large angles for pi+ 3He and pi- 3H, it does not reproduce the structure seen in the experiment.Comment: 15 pages + 5 figure

A drug repurposing screen for whipworms informed by comparative genomics.

Hundreds of millions of people worldwide are infected with the whipworm Trichuris trichiura. Novel treatments are urgently needed as current drugs, such as albendazole, have relatively low efficacy. We have investigated whether drugs approved for other human diseases could be repurposed as novel anti-whipworm drugs. In a previous comparative genomics analysis, we identified 409 drugs approved for human use that we predicted to target parasitic worm proteins. Here we tested these ex vivo by assessing motility of adult worms of Trichuris muris, the murine whipworm, an established model for human whipworm research. We identified 14 compounds with EC50 values of ≤50 μM against T. muris ex vivo, and selected nine for testing in vivo. However, the best worm burden reduction seen in mice was just 19%. The high number of ex vivo hits against T. muris shows that we were successful at predicting parasite proteins that could be targeted by approved drugs. In contrast, the low efficacy of these compounds in mice suggest challenges due to their chemical properties (e.g. lipophilicity, polarity, molecular weight) and pharmacokinetics (e.g. absorption, distribution, metabolism, and excretion) that may (i) promote absorption by the host gastrointestinal tract, thereby reducing availability to the worms embedded in the large intestine, and/or (ii) restrict drug uptake by the worms. This indicates that identifying structural analogues that have reduced absorption by the host, and increased uptake by worms, may be necessary for successful drug development against whipworms

Monitoring Handbook 2: Developing a multiparty monitoring plan.

Developing a clear, concise plan for how monitoring will be done is an essential part of any monitoring program. A monitoring plan will help your group make sure that the date you gather are useful and meaningful. It ensures that information is collected at the right time and place and helps to provide transparency, an important part of the multiparty monitoring process. This handbook covers the basic steps in designing a monitoring plan