5 research outputs found
A ction and Enlightenment Functions of Research
- Author
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
Sirtuin/Sir2 phylogeny, evolutionary considerations and structural conservation
- Author
- A. Brunet
- A. Horst van der
- A. Vaquero
- A. Vaquero
- A. Vaquero
- A.A. Sauve
- A.F. Straight
- A.J. Klar
- A.M. Waterhouse
- A.N. Khan
- A.W. Tsang
- Anton Gartner
- B. Rogina
- B. Schwer
- B. Schwer
- B.J. North
- B.L. Newman
- C. Bowler
- C. Schlicker
- C. Wang
- C.E. Fritze
- D.A. Sinclair
- D.B. Lombard
- D.H. Huson
- E. Ford
- E. Ghedin
- E. Michishita
- E. Michishita
- E.C. Meng
- E.F. Pettersen
- F. Picard
- F. Yeung
- G. Blander
- G. Liszt
- H. Vaziri
- H. Yamamoto
- H.A. Tissenbaum
- H.D. Ou Der
- H.Y. Cohen
- J. Du
- J. Landry
- J. Luo
- J. Mead
- J. Min
- J.C. Tanny
- J.C. Tanny
- J.G. Wood
- J.H. Chang
- J.L. Avalos
- J.M. Dai
- J.M. Ivy
- J.M. Ivy
- J.S. Smith
- J.T. Rodgers
- K. Pruitt
- K. Zhao
- K. Zhao
- K. Zhao
- K.G. Tanner
- L. Eichinger
- L.D. Stein
- M. Braunstein
- M. Braunstein
- M. Bryk
- M. Hiratsuka
- M. Kaeberlein
- M. Potente
- M. Solignac
- M. Srivastava
- M. Tanno
- M.A. Holbert
- M.C. Haigis
- M.C. Haigis
- M.C. Motta
- M.D. Katinka
- M.I. Rosenberg
- M.J. Gardner
- M.S. Finnin
- N. Ahuja
- N. Dali-Youcef
- N. King
- O.M. Aparicio
- P. Hu
- P. Oberdoerffer
- Q. Jin
- R.A. Frye
- S. Gottlieb
- S. Greiss
- S. Imai
- S. Pankow
- S. Richards
- S.A. Rensing
- S.C. Dryden
- S.L. Baldauf
- S.U. Astrom
- Sebastian Greiss
- T. Inoue
- T.L. Kawahara
- T.M. Kowieski
- V.D. Longo
- W. Shou
- W.C. Hallows
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/11/2009
- Field of study
The sirtuins are a protein family named after the first identified member, S. cerevisiae Sir2p. Sirtuins are protein deacetylases whose activity is dependent on NAD(+) as a cosubstrate. They are structurally defined by two central domains that together form a highly conserved catalytic center, which catalyzes the transfer of an acetyl moiety from acetyllysine to NAD(+), yielding nicotinamide, the unique metabolite O-acetyl-ADP-ribose and deacetylated lysine. One or more sirtuins are present in virtually all species from bacteria to mammals. Here we describe a phylogenetic analysis of sirtuins. Based on their phylogenetic relationship, sirtuins can be grouped into over a dozen classes and subclasses. Humans, like most vertebrates, have seven sirtuins: SIRT1-SIRT7. These function in diverse cellular pathways, regulating transcriptional repression, aging, metabolism, DNA damage responses and apoptosis. We show that these seven sirtuins arose early during animal evolution. Conserved residues cluster around the catalytic center of known sirtuin family members
Polyglutamine Diseases
- Author
- A. Abel
- A. Emili
- A. Lunkes
- A. McCampbell
- A. McCampbell
- A. Wyttenbach
- A. Wyttenbach
- A. Yamamoto
- A.C. Ludolph
- A.E. Lang
- A.M. Andres
- A.P. Lieberman
- A.R. Spada La
- A.R. Spada La
- A.R. Spada La
- A.S. Hackam
- A.V. Panov
- A.W. Dunah
- B. Chattopadhyay
- B.O. Evert
- C. Zuccato
- C. Zuhlke
- C.A. Gutekunst
- C.C. Huang
- C.C. Tsai
- C.H. Zuhlke
- C.J. Cummings
- C.J. Cummings
- C.J. Cummings
- C.L. Wellington
- C.L. Wellington
- C.M. Everett
- D. Goti
- D. Helmlinger
- D. Helmlinger
- D. Kretzschmar
- D. Saluja
- D.C. Rubinsztein
- D.C. Rubinsztein
- D.G. Hay
- D.L. Smith
- D.L. Stenoien
- D.L. Stenoien
- D.L. Swope
- D.P. Huynh
- D.P. Huynh
- E. Hockly
- E. Sapp
- E. Scherzinger
- E. Scherzinger
- E. Trushina
- E.C. Hirsch
- E.J. Slow
- E.P. Leeflang
- F. Li
- F. Maltecca
- F. Muller
- F. Piccioni
- F. Squitieri
- F.C. Nucifora Jr
- G. Morfini
- G. Schaffar
- G. Schilling
- G. Schilling
- G. Schilling
- G. Szebenyi
- G. Yvert
- G. Yvert
- G.A. Garden
- H. Adachi
- H. Adachi
- H. Fujigasaki
- H. Li
- H. Li
- H. Li
- H. Takano
- H. Zhou
- H.B. Clark
- H.G. Serra
- H.Y. Chan
- H.Y. Zoghbi
- Huntingtonâs Disease Collaborative Research Group
- I. Lerer
- I. Martianov
- I. Sanchez
- J. Cornett
- J. Gafni
- J. Gafni
- J. Jonasson
- J.A. Parker
- J.C. Lievens
- J.D. Wood
- J.G. Hodgson
- J.L. Li
- J.M. Boutell
- J.M. Ordway
- J.M. Warrick
- J.S. Steffan
- J.S. Steffan
- J.Y. Li
- K. Ishikawa
- K. Ishikawa
- K. Murai
- K. Obrietan
- K. Sato
- K.B. Kegel
- K.L. Sugars
- L. Bodai
- L. Mangiarini
- L. Zhang
- L.R. Gauthier
- M. DiFiglia
- M. Johannessen
- M. Katsuno
- M. Li
- M. Minamiyama
- M. Ralser
- M. Tanaka
- M. Yamada
- M.A. Poirier
- M.D. Conkright
- M.F. Beal
- M.F. Perutz
- M.L. Schmitz
- M.T. Usdin
- N. Heintz
- N.R. Jana
- N.R. Jana
- N.S. Wexler
- O. Hansson
- P. Fernandez-Funez
- P. Kazemi-Esfarjani
- P.F. Behrens
- P.W. Faber
- R. Luthi-Carter
- R. Luthi-Carter
- R. Truant
- R.E. Mrak
- R.L. Albin
- R.L. Albin
- S. Chen
- S. Chen
- S. Chen
- S. Chen
- S. Gunawardena
- S. Gunawardena
- S. Holbert
- S. Karlin
- S. Kim
- S. Kuemmerle
- S. Yue
- S.E. Browne
- S.E. Browne
- S.H. Li
- S.H. Li
- S.H. Li
- S.H. Satyal
- S.J. Reid
- S.J. Tabrizi
- S.K. Pollitt
- S.K. Singhrao
- S.T. Suhr
- S.W. Davies
- T. Agalioti
- T. Grunewald
- T. Ikeuchi
- T. Kato
- T. Mantamadiotis
- T. Shimohata
- W. Gu
- W.C. Lee
- X. Lin
- X. Zhang
- Y. Chai
- Y. Chai
- Y. Chai
- Y. Chai
- Y. Hayashi
- Y. Hayashi
- Y. Kobayashi
- Y. Takiyama
- Y. Takiyama
- Y. Toyoshima
- Y.J. Kim
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2006
- Field of study
Physico-chemical and formulation-induced veterinary drug-product bioinequivalencies
- Author
- Aggag M.
- Aguiar A.J.
- Aguiar A.J.
- Albon N.
- Allen P.V.
- Anderson R.A.
- Anello J.A.
- Archimbault P.
- Archimbault P.
- Archimbault P.
- Archimbault P.
- Baker A.W.
- Ballard B.E.
- Bates T.R.
- Batuyios D.H.
- Benet L.Z.
- Benet L.Z.
- Bird J.C.
- Blaug S.M.
- Blom L.
- Bochner F.
- Bogardus J.B.
- Bojarski A.
- Bojarski A.
- British Pharmacopoeia
- Brooker P.J.
- Brunner E.
- Buckwalter F.H.
- Buckwalter F.H.
- Buckwalter F.H.
- Burt H.M.
- Burt H.M.
- Button C.
- Cambell C.B.
- Carless J.E.
- Carless J.E.
- Carstensen J.T.
- Carstensen J.T.
- Carstensen J.T.
- Carstensen J.T.
- Chin L.
- Coles C.L.J.
- Crommelin D.J.A.
- Crommelin D.J.A.
- Curr C.
- Daabis N.A.
- Dare J.G.
- Davis S.S.
- Davis W.W.
- Douglas J.R.
- Douglas J.R.
- Dowrick J.S.
- Duesel B.F.
- Ebian A.R.
- Ebian A.R.
- El-Masry S.
- Ellin R.I.
- Embil K.
- Emerson J.L.
- Engel R.H.
- Eriksson S.O.
- Feldman S.
- Fendler J.H.
- Fenton A.H.
- Ferguson R.H.
- Finholt P.
- Florence A.T.
- Florence A.T.
- Fraunfelder F.T.
- Frederick KJ.
- Frey H.-H.
- Fung H.-L.
- Galante R.N.
- Gantt C.L.
- Gemmell M.A.
- Gemmell M.A.
- Gibaldi M.
- Gissinger D.
- Gordon H.
- Grant N.H.
- Grote I.
- Grzegorzewics W.
- Gunsel W.C.
- Guttman D.E.
- Hajratwala B.R.
- Haleblian J.
- Haleblian J.K.
- Haleblian J.K.
- Harris W.A.
- Hayton W.L.
- Hem S.L.
- Hem S.L.
- Hess H.
- Higuchi T.
- Higuchi T.
- Higuchi T.
- Higuchi T.
- Higuchi W.I.
- Higuchi W.I.
- Hirano K.
- Hirano K.
- Hirano K.
- Hirano K.
- Hixson A.W.
- Hixson A.W.
- Holbert J.M.
- Horikoshi I.
- Horikoshi I.
- Horikoshi I.
- Horikoshi I.
- Ibrahim H.G.
- Immelman A.
- Jacobs A.L.
- Javard K.A.
- Johnson C.A.
- Jounela A.J.
- Jounela A.J.
- Juncher H.
- Junginger H.
- Junginger H.
- Junginger H.
- Kalatzis E.
- Kato R.
- Kern C.J.
- Khalil S.A.
- Khalil S.A.
- Khalil S.A.
- Khalil S.A.
- Khalil S.A.H.
- Kondritzer A.A.
- Kornblum S.S.
- Kornblum S.S.
- Koshy K.T.
- Kramer P.A.
- Kunin CM.
- Lachman L.
- Lachman L.
- Lachman L.
- Lees K.A.
- Leeson L.J.
- Levy G.
- Levy G.
- Levy G.
- Levy G.
- Levy G.
- Levy G.
- Levy G.
- Lin S.-L.
- Lovering E.G.
- Macek T.J.
- Magrane W.G.
- Malone M.H.
- Mayersohn M.
- Mayersohn M.
- McGinity J.W.
- McGiruty J.W.
- Mendes R.W.
- Mercer H.D.
- Miller L.C.
- Milosovich G.
- Mitchell A.G.
- Mitchell A.G.
- Mitchell A.G.
- Miyazaki S.
- Miyazaki S.
- Miyazaki S.
- Miyazaki S.
- Monkhouse D.C.
- Monkhouse D.C.
- Moran I.
- Morozowich W.
- Morozowich W.
- Morrison A.B.
- Moustafa M.A.
- Moustafa M.A.
- Mullins J.
- Muranushi N.
- Naggar V.F.
- Naggar V.F.
- Naggar V.F.
- Naggar V.F.
- Nakai Y.
- Nakai Y.
- Nakai Y.
- Nakai Y.
- Nakai Y.
- Nelson E.
- Nelson E.
- Nelson E.
- Nelson E.
- Nernst W.
- Neville G.A.
- Neville G.A.
- Nogami H.
- Nogami H.
- Nogami H.
- O'Reilly R.A.
- Oishi H.
- Paulsen B.J.
- Pavan-Langston D.
- Pearson J.T.
- Peterhoff R.
- Piccolo J.
- Piccolo J.
- Polderman J.
- Polderman J.
- Ponting L.M.
- Poole J.W.
- Poole J.W.
- Pope D.G.
- Pope D.G.
- Pope D.G.
- Pope D.G.
- Pope D.G.
- Pope D.G.
- Pope D.G.
- Pope D.G.
- Prescott L.F.
- Rasmussen F.
- Rasmussen F.
- Rasmussen F.
- Repta A.J.
- Reuning R.H.
- Reuning R.H.
- Rick A.
- Riegelman S.
- Riegelman S.
- Riegelman S.
- Roberts G.
- Rosoff M.
- Saad H.Y.
- Schanker L.S.
- Schipper I.A.
- Schoonen A.J.M.
- Schoonen A.J.M.
- Shami E.
- Shastri S.
- Shaw T.R.D.
- Shaw T.R.D.
- Shefter E.
- Shefter E.
- Shell J.
- Shihab F.A.
- Simmons D.L.
- Singh P.
- Singh P.
- Snyder L.R.
- Solvang S.
- Solvang S.
- Sorby D.L.
- Speiser P.
- Spiegel A.J.
- Stagner W.C.
- Stephens V.C.
- Stoughton R.B.
- Strickland W.A.
- Stuurman-Bieze A.G.G.
- Summers M.P.
- Svendsen O.
- Takahashi T.
- Takahashi T.
- Takahashi T.
- Takahashi T.
- Takahashi T.
- Takahashi T.
- Takahashi T.
- Tamura C.
- Tanaka N.
- Tardif R.
- Thomas P.L.
- Tingstad J.
- Treasure C.R.G.
- Troup A.E.
- Trueblood J.H.
- Tyrer J.H.
- Utsumi I.
- Varley A.B.
- Wai K.
- Wai K.
- Watanabe A.
- Watson A.D.J.
- Watson A.D.J.
- Watson A.D.J.
- Weintraub H.
- Wilson C.D.
- Yamamoto K.
- Yamamoto R.
- Ziv G.
- Ziv G.
- Publication venue
- 'Wiley'
- Publication date
- Field of study
El tiempo de la archivĂstica: un estudio de sus espacios de racionalidad histĂłrica
- Author
- ABADAL E
- AGUINAGALDE F
- AgustĂn Vivas Moreno
- ALBERCH FUGUERAS R.
- ALBERCH FUGUERAS R.
- ALBERCH RamĂłn
- ALCĂNTARA D
- ARRILLAGA TORRENS R
- ARĂSTEGUI J
- BADILLO NIETO M
- BAIRD D.
- BAUER G
- BAUTIER R. H.
- BEARMAN D
- BEARMAN D.A.
- BELLOTTO H. L.
- BERNER R.C.
- BIRAGHI C
- BLACK E
- BRADSHER J.G.
- BRAUDEL F
- BRENNEKE A
- BRENNEKE A
- BRENNEKE A
- BRENNEKE A
- BRICHFORD M.J.
- BUCCI O
- BUCCI O
- CARRERAS J.J.
- CARUCCI P.
- CARUCCI P.
- CASANOVA E
- CASANOVA E
- CASANOVA E
- CASSESE L
- CAYETANO MARTĂN C
- CENCETTI G
- CENCETTI G
- CENCETTI G
- CERDĂ DĂAZ J
- CHABIN M.A.
- CHAMPAGNE M.
- CHAMPOLLION-FIGEAC A
- CHAUMIER J
- CICERI A
- COLLINGWOOD R.G.
- CONDE VILLAVERDE M. L.
- CONTINOLO G
- COOK M
- COOK M
- COOK M
- COOK M
- COOK T
- CORTĂS ALONSO V
- CORTĂS ALONSO V.
- COUTURE C
- COUTURE C.
- COUTURE C.
- COUTURE C.
- COX R.J.
- COX R.J.
- COX RJ
- CRAIG B.L.
- CRUZ MUNDET J. R
- CRUZ MUNDET J.R.
- CRUZ MUNDET J.R.
- CRUZ MUNDET J.R.
- D'ADDARIO A
- DE DIOS S
- DEL VALLE GASTAMINZA F
- DESJARDINS G
- DOLLAR C.M
- DOLLAR C.M.
- DORS A
- DUCHEIN M
- DUCHEIN M
- DUCKETT K. W.
- DUPLĂ DEL MORAL A
- DâADDARIO A
- EASTWOOD T
- ECKHART C.F.
- ESCOLAR H
- ESPOSEL J. P.
- EVANS F.B
- FAVIER J
- FELICE R. de
- FERNĂNDEZ BAJĂN M.T
- FERNĂNDEZ GIL P
- FERNĂNDEZ ROMERO I
- FISHBEIN M
- FONTANA J
- FRANZ E.G.
- FRANZ ECKHART G
- FUSTER RUIZ F
- FUSTER RUIZ F
- GALLEGO DOMINGUEZ O.
- GALLEGO DOMĂNGUEZ O
- GARCĂA RUIPĂREZ M.
- GAUR A
- GONZĂLEZ RAMĂREZ L
- GĂEMES
- HEDSTROM M
- HEDSTROM M
- HEREDIA BERRERA A
- HILL M. R.
- HIVES C.
- HODSON S.H.
- HOLBERT S. E
- IMBERT G
- JENKINSON H
- KANE L. M.
- KECSKEMETI Charles
- KOSELLECK R
- LLANSĂ J
- LODOLINI E
- LODOLINI E
- LODOLINI E
- LĂPES L. C.
- LĂPEZ GĂMEZ P
- LĂPEZ VIDRIERO MÂȘ L
- LĂPEZ YEPES J
- LĂPEZ YEPES J
- LĂPEZ YEPES J
- LĂPEZ YEPES J.
- MARTĂN FUERTES J.A.
- MATILLA TASCON A
- MAZZOLENI J
- MAZZOLENI J
- McCRANK L.J.
- MENDO CARMONA C
- MENDO CARMONA C
- MENNE-HARITZ A
- MOLINA NORTES J.
- MORAZĂ C
- MOREIRO GONZĂLEZ J. A.
- MULLER S.
- MUĂIZ COELLO J
- MUĂOZ GUTIĂRREZ C
- NĂĂEZ FERNĂNDEZ E.
- OTLET P
- PANELLA A
- PEDERSON A. E.
- PEDERSON A.E.
- PEIS E
- PELOU P
- PENN I
- PENN I.A
- PEREIRA M
- PEROTIN Y
- PESCADOR DEL HOYO M.C.
- PLESSI G
- POSNER E
- POSSNER E
- PĂREZ HERRERO E
- ROBERGE M
- ROBERGE M
- ROBERGE M
- ROBERGE M
- ROBERGE Michel
- ROBERGE Michel
- RODRĂGUEZ DE DIEGO J.L.
- RODRĂGUEZ DE DIEGO J.L.
- RODRĂGUEZ MIGUEL L
- RODRĂGUEZ NEILA J.F.
- ROMERO TALLAFIGO M
- ROMERO TALLAFIGO M
- RUBIO MERINO P
- RUBIO Y BORRĂS M
- RUĂZ RODRĂGUEZ A.
- SANCHĂS MORENO F
- SANDRI L
- SASTRE SANTOS E
- SAUNDERS W.L.
- SCHAMBER L
- SCHELLENBERG T. R.
- SCHELLENBERG T. R.
- SCHELLENBERG T. R.
- TADDEL P
- TAMAYO A
- TANODI A
- TAYLOR H. A
- TAYLOR H.A.
- URANGA COGOLLOS C
- VELASCO
- VINCENT C.P
- VIVAS MORENO A
- VOSS J
- WHITE L
- ĂLVAREZ COCA MÂȘ J
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study