Initial investigation of test-retest reliability of home-to-home teleneuropsychological assessment in healthy, English-speaking adults

Prior teleneuropsychological research has assessed the reliability between in-person and remote administration of cognitive assessments. Few, if any, studies have examined the test-retest reliability of cognitive assessments conducted in sequential clinic-to-home or home-to-home teleneuropsychological evaluations - a critical issue given the state of clinical practice during the COVID-19 pandemic. This study examined this key psychometric question for several cognitive tests administered over repeated videoconferencing visits 4-6 months apart in a sample of healthy English-speaking adults. A total of 44 participants (ages 18-75) completed baseline and follow-up cognitive testing 4-6 months apart. Testing was conducted in a home-to-home setting over HIPAA-compliant videoconferencing meetings on participants' audio-visual enabled laptop or desktop computers. The following measures were repeated at both virtual visits: the Controlled Oral Word Association Test (FAS), Category Fluency (Animals), and Digit Span Forward and Backward from the Wechsler Adult Intelligence Scale, Fourth Edition. Intraclass correlation coefficients (ICC), Pearson correlations, root mean square difference (RMSD), and concordance correlation coefficients (CCC) were calculated as test-retest reliability metrics, and practice effects were assessed using paired-samples t-tests. Some tests exhibited small practice effects, and test-retest reliability was marginal or worse for all measures except FAS, which had adequate reliability (based on ICC and r). Reliability estimates with RMSD suggested that change within +/- 1 SD on these measures may reflect typical test-retest variability. The included cognitive measures exhibited questionable reliability over repeated home-to-home videoconferencing evaluations. Future teleneuropsychology test-retest reliability research is needed with larger, more diverse samples and in clinical populations.F31 AG062158 - NIA NIH HHS; R01 AG054671 - NIA NIH HHS; R01 AG066823 - NIA NIH HHSAccepted manuscrip

Evaluation of Effect of Caffeic Acid Phenyl Ester on Acute T-Lymphoblastic Leukemia Cells by Mitochondria and Peroxisome

European Multidisciplinary Cancer Congress on Integrating Basic and Translational Science, Surgery, Radiotherapy, Medical oncology, Advocacy and Care -- SEP 23-27, 2011 -- Stockholm, SWEDENWOS: 00029575280226

Expression profiling of RE1-silencing transcription factor (REST), REST corepressor 1 (RC0R1), and Synapsin 1 (SYN1) genes in human gliomas

PubMed ID: 27685921Purpose: The repressor element 1 (RE-1) silencing transcription f actor (REST) is a transcription f actor which represses the expression of neuronal differentiation-related genes including SYN1 gene. CoREST, encoded by RCOR1 gene, binds to the REST protein for remodeling of chromatin structure. Although there is a relation among REST, RCOR1, and SYN1 genes, the role of these genes in glioma tumors is still unclear. In this study, expressions of REST, RC0R1, and SYN1 genes were detected in primary cultures derived from tumor samples of diffuse astrocytoma (DA), anaplastic oligodendroglioma (AO), and glioblastoma multiforme (GBM) cases. Methods: Expression profiles were analysed by RT-qPCR and the copy number variations were examined with qPCR in primary cultures. ChIP assay was performed to show binding characteristics of REST and CoREST proteins on promoter region of SYN1 gene. Results: Means of relative expression for REST were as follows: 0.7898, 0.7606, and 0.7318 in DA, AO, and GBM groups, respectively. For RCOR1, expression means in DA, AO, and GBM groups were 0.7203, 0.7334, and 0.7230, respectively. SYN1 expression means were as follows: 0.3936, 0.3192, and 0.3197 in DA, AO, and GBM groups, respectively. Neither gain nor loss of copy numbers were detected for REST and RC0R1 genes in all groups. Copy loss for SYN1 was detected in primary culture of a DA case. REST and CoREST presented positive precipitation pattern on promoter region of SYN1 gene. Conclusions: Expressions of REST and RC0R1 genes may downregulate SYN1 expression in gliomas. Low expression pattern of SYNl may maintain cancer stem-like phenotype which contributes to development of gliomas

Genistein-induced apoptosis of HL-60 cells via effecting human telomerase reverse transcriptase activity

36th FEBS Congress of the Biochemistry for Tomorrows Medicine -- JUN 25-30, 2011 -- Torino, ITALYWOS: 000292333103006Federat Soc Biochem & Mol Bio

PROMOTOR HYPERMETHYLATION-MEDIATED DOWN-REGULATION OF RUNX3 GENE IN HUMAN BRAIN TUMORS

9th Meeting of European-Association-of-NeuroOncology -- SEP 16-19, 2010 -- Maastricht, NETHERLANDSWOS: 000281184800125European Assoc NeuroOnco