45 research outputs found

    Direct Stenting versus Conventional Stenting in Patients with ST-Segment Elevation Myocardial Infarction—A COMPARE CRUSH Sub-Study

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    Background: Direct stenting (DS) compared with conventional stenting (CS) after balloon predilatation may reduce distal embolization during percutaneous coronary intervention (PCI), thereby improving tissue reperfusion. In contrast, DS may increase the risk of stent underexpansion and target lesion failure. Methods:In this sub-study of the randomized COMPARE CRUSH trial (NCT03296540), we reviewed the efficacy of DS versus CS in a cohort of contemporary, pretreated ST-segment elevation myocardial infarction (STEMI) patients undergoing primary PCI. We compared DS versus CS, assessing (1) stent diameter in the culprit lesion, (2) thrombolysis in myocardial infarction (TIMI) flow in the infarct-related artery post-PCI and complete ST-segment resolution (STR) one-hour post-PCI, and (3) target lesion failure at one year. For proportional variables, propensity score weighting was applied to account for potential treatment selection bias. Results: This prespecified sub-study included 446 patients, of whom 189 (42%) were treated with DS. Stent diameters were comparable between groups (3.2 ± 0.5 vs. 3.2 ± 0.5 mm, p = 0.17). Post-PCI TIMI 3 flow and complete STR post-PCI rates were similar between groups (DS 93% vs. CS 90%, adjusted OR 1.16 [95% CI, 0.56–2.39], p = 0.69, and DS 72% vs. CS 58%, adjusted OR 1.29 [95% CI 0.77–2.16], p = 0.34, respectively). Moreover, target lesion failure rates at one year were comparable (DS 2% vs. 1%, adjusted OR 2.93 [95% CI 0.52–16.49], p = 0.22). Conclusion:In this contemporary pretreated STEMI cohort, we found no difference in early myocardial reperfusion outcomes between DS and CS. Moreover, DS seemed comparable to CS in terms of stent diameter and one-year vessel patency.</p

    Guilds in the transition to modernity: the cases of Germany, United Kingdom, and the Netherlands

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    One important aspect of the transition to modernity is the survival of elements of the Old Regime beyond the French Revolution. It has been claimed that this can explain why in the late 19th and early 20th centuries some Western countries adopted national corporatist structures while others transformed into liberal market economies. One of those elements is the persistence or absence of guild traditions. This is usually analyzed in a national context. This paper aims to contribute to the debate by investigating the development of separate trades in Germany, the United Kingdom and the Netherlands throughout the 19th century. We distinguish six scenarios of what might have happened to crafts and investigate how the prevalence of each of these scenarios in the three countries impacted on the emerging national political economies. By focusing on trades, rather than on the national political economy, our analysis demonstrates that in each country the formation of national political economies and citizenship rights was not the result of a national pattern of guild survival. Rather, the pattern that emerged by the end of the 19th century was determined by the balance between old and new industries, and between national and regional or local government

    Building a community of scholars: Positive relationships in a holding environment

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    Academic staff in Australian universities are experiencing significant change, generating stress and anxiety. Caught up in these emotions, individuals seek the means to manage them. Kahn (2001) suggests that an appropriate means for management of negative affect is a holding environment. A ‘collective auto-ethnography’, this paper describes the holding environment constructed by a group of academics focussing on interpersonal relationships which are at the core of the Community of Scholars (Goodman 1964). It offers evidence that the holding environment created by this mutual collaboration between like-minded people has served to provide support for those involved. A holding environment may be an option to be considered by others facing dynamic change

    Stability and demulsification of petroleum emulsions

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    Het Post-COVID-syndroom: hoe definiëren we het en hoe vaak komt het voor?

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    Serie: Aanhoudende klachten na COVID-19-besmetting Aanhoudende klachten na een COVID-besmetting, oftewel, het post-COVID-syndroom (PCS, voorheen vaak Long COVID genoemd) krijgt in het nieuws en in de internationale literatuur (Peter et al., 2022, Taquet et al., 2021) steeds meer aandacht. Er is echter nog geen consensus over een bruikbare definitie voor praktijk en onderzoek. Definities lopen uiteen en vaak betreft het onderzoek onder mensen die wegens COVID-19 in het ziekenhuis hebben gelegen. Hierdoor is het lastig voor zorgverleners en onderzoekers om patiënten met PCS te herkennen. Bovendien is een concrete definitie nodig om een schatting te kunnen geven van hoe vaak PCS voorkomt en bij wie, om vervolgens in kaart te brengen wat oorzaken en risico’s zijn en welke zorg deze patiënten krijgen. In deze factsheet vergelijken we het voorkomen van PCS bij verschillende definities en verschillende databronnen; te weten elektronische patiëntendossiers (EPD’s) van de huisartsenzorg en vragenlijsten ingevuld door COVID-19-patiënten
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