Performance and polarization response of slit homogenizers for the GeoCarb mission

The observing strategy of the Geostationary Carbon Observatory (GeoCarb), which is a “step and stare” approach, can lead to distortions in the instrument spectral response function (ISRF) when there are gradients in brightness across instrument field of view. These distortions induce errors in the retrieved trace gases. In order to minimize these errors, the GeoCarb instrument design was modified to include a “slit homogenizer” whose purpose is to scramble the pattern of the incoming light and effectively remove the ISRF distortions caused by the variations in illumination across the slit. As a risk reduction, GeoCarb procured six different homogenizers and had them tested for performance in a benchtop optical system. The major finding is that the homogenizer performance depends strongly on the polarization of the incoming light, with the sensitivity growing as a function of wavelength. The width of the ISRF is substantially smaller when the light is vertically polarized (orthogonal to the slit length) compared to horizontally polarized (parallel to the slit length), and the throughput is accordingly reduced. These effects are due to the effects of the gold coating and high incidence angles present in the GeoCarb homogenizer design, which was verified using a polarization-dependent model generalized from previous homogenizer modeling work. The results strongly recommend controlling the polarization of the light entering a similar implementation using a polarizer, depolarizer, or polarization scrambler for other instruments attempting to mitigate scene illumination non-uniformity effects, as well as a robust characterization of the polarization sensitivity of all key subsystems.</p

The role of ipsilateral motor areas in hand motor function in healthy ageing – insights from online TMS

EPV

The role of contralesional motor areas in early motor recovery – evidence from event-related (“online”) TMS

BackgroundTMS studies examining the role of the unaffected hemisphere in motor function after stroke have mainly focused on the contralesional primary motor cortex (M1), revealing both supporting (Lotze et al., 2006 and Rehme et al., 2011) as well as disturbing (Vollmer et al., 2015 and Nowak et al., 2008) influence for recovery of function. However, the relevance of other contralesional motor areas for paretic hand function has rarely been examined, especially with respect to motor recovery in the first days and weeks after stroke. Therefore, we tested the effects of online-TMS applied to contralesional primary motor cortex, anterior intraparietal sulcus (aIPS) and dorsal premotor cortex (dPMC) while stroke patients performed different motor tasks with their paretic hand.MethodsPatients with first-ever ischemic left hemispheric stroke performed motor tasks of different complexities with their paretic right hand while being stimulated with ‘online TMS’: (i) index finger tapping, (ii) hand tapping, (iii) visuomotor pointing task (pointing back and forth between two defined targets) and (iv) simple reaction time task. Performance was measured using a three-dimensional motion analyzer system (Zebris). Patients were measured in the acute stage after stroke.ResultsCompared to healthy controls, acute stroke patients showed reduced finger tapping amplitudes during TMS interference with ipsilateral (=contralesional) aIPS. Likewise, reaction times deteriorated upon contralesional aIPS stimulation in stroke patients but not in controls. Finally, accuracy in the 3D pointing task not only deteriorated upon aIPS stimulation (like in controls) but in addition also during interference with contralesional M1, which was exclusively found in the stroke patients group.ConclusionWe here found evidence that especially anterior intraparietal cortex –an area critically engaged in hand motor function by means of parieto-frontal loops– has a relevant influence on motor performance of the paretic hand early after stroke. Therefore, aIPS might constitute an interesting stimulation target for excitability enhancing brain stimulation protocols in order to support recovery of function after stroke

Recovery from apraxic deficits and its neural correlate

Background and Objective: Apraxia is a deficit of motor cognition leading to difficulties in actual tool use, imitation of gestures, and pantomiming object use. To date, little data exist regarding the recovery from apraxic deficits after stroke, and no statistical lesion mapping study investigated the neural correlate of recovery from apraxia. Accordingly, we here examined recovery from apraxic deficits, differential associations of apraxia task (imitation vs. pantomime) and effector (bucco-facial vs. limb apraxia) with recovery, and the underlying neural correlates. Methods: We assessed apraxia in 39 patients with left hemisphere (LH) stroke both at admission and approximately 11 days later. Furthermore, we collected clinical imaging data to identify brain regions associated with recovery from apraxic deficits using voxel-based lesion-symptom mapping (VLSM). Results: Between the two assessments, a significant recovery from apraxic deficits was observed with a tendency of enhanced recovery of limb compared to bucco-facial apraxia. VLSM analyses revealed that within the lesion pattern initially associated with apraxia, lesions of the left insula were associated with remission of apraxic deficits, whereas lesions to the (inferior) parietal lobe (IPL; supramarginal and angular gyrus) and the superior longitudinal fasciculus (SLF) were associated with persistent apraxic deficits. Conclusions: Data suggest that lesions affecting the core regions (and white matter) of the fronto-parietal praxis network cause more persistent apraxic deficits than lesions affecting other regions (here: the left insula) that also contribute to motor cognition and apraxic deficits

The use of dynamic O-(2-18F-fluoroethyl)-L-tyrosine PET in the diagnosis of patients with progressive and recurrent glioma

Background We evaluated the diagnostic value of static and dynamic O-(2-[18F]fluoroethyl)-l-tyrosine (18F-FET) PET parameters in patients with progressive or recurrent glioma.Methods We retrospectively analyzed 132 dynamic 18F-FET PET and conventional MRI scans of 124 glioma patients (primary World Health Organization grade II, n = 55; grade III, n = 19; grade IV, n = 50; mean age, 52 ± 14 y). Patients had been referred for PET assessment with clinical signs and/or MRI findings suggestive of tumor progression or recurrence based on Response Assessment in Neuro-Oncology criteria. Maximum and mean tumor/brain ratios of 18F-FET uptake were determined (20–40 min post-injection) as well as tracer uptake kinetics (ie, time to peak and patterns of the time–activity curves). Diagnoses were confirmed histologically (95%) or by clinical follow-up (5%). Diagnostic accuracies of PET and MR parameters for the detection of tumor progression or recurrence were evaluated by receiver operating characteristic analyses/chi-square test.Results Tumor progression or recurrence could be diagnosed in 121 of 132 cases (92%). MRI and 18F-FET PET findings were concordant in 84% and discordant in 16%. Compared with the diagnostic accuracy of conventional MRI to diagnose tumor progression or recurrence (85%), a higher accuracy (93%) was achieved by 18F-FET PET when a mean tumor/brain ratio ≥2.0 or time to peak <45 min was present (sensitivity, 93%; specificity, 100%; accuracy, 93%; positive predictive value, 100%; P < .001).Conclusion Static and dynamic 18F-FET PET parameters differentiate progressive or recurrent glioma from treatment-related nonneoplastic changes with higher accuracy than conventional MRI